中医文献检索.doc

【精品文档】如有侵权，请联系网站删除，仅供学习与交流中医文献检索.精品文档.计算机检索实习题（共计30分）学号： 姓名： 第一题题 请查询有关中医药抗慢性阻塞性肺疾病（COPD）方面的文献。（20分）一、数据库检索数据库1：中国生物医学文献数据库（CBM Web）（2分）检索表达式：("慢性阻塞性肺疾病"全字段 OR "COPD"全字段 OR "慢性气道阻塞性疾病"全字段 OR "慢性阻塞肺疾病"全字段 OR "COAD"全字段 OR "慢性气道阻塞"全字段 OR "肺疾病, 慢性阻塞性"主题词) AND "中医药"常用字段数据库2：中国知网（CNKI，要求查询这个平台上的期刊全文库、学位论文全文库和会议论文全文库）（2分）期刊库检索表达式：( ( 主题=慢性阻塞性肺疾病 或者 主题=COPD ) 并且 分类号=r2? ) (精确匹配),专辑导航：全部; 数据库：学术期刊 单库检索学位论文库检索表达式：( 主题=慢性阻塞性肺疾病 或者 主题=COPD ) 并且 (中图分类号=r2? 或者 分类号=r2?) ) (精确匹配),专辑导航：全部; 数据库：博硕士学位论文 跨库检索会议论文库检索表达时：( 主题=慢性阻塞性肺疾病 或者 主题=COPD ) 并且 分类号=r2? ) (精确匹配),专辑导航：全部; 数据库：会议论文 跨库检索数据库3：维普科技期刊全文库（1分）检索表达式：题名或关键词=慢性阻塞性肺疾病 或 题名或关键词=COPD 与 分类号=R2 与 专业=医药卫生 与 范围=全部期刊数据库4：Pubmed数据库（2分）检索表达式：("pulmonary disease, chronic obstructive"MeSH Terms OR ("pulmonary"All Fields AND "disease"All Fields AND "chronic"All Fields AND "obstructive"All Fields) OR "chronic obstructive pulmonary disease"All Fields OR "copd"All Fields) AND ("Chin Med"Journal OR ("chinese"All Fields AND "medicine"All Fields) OR "chinese medicine"All Fields)二、典型文献（选取5篇最相关中文文献和5篇英文文献，为所有数据库综合的结果，如果两个数据库中的文献有重复，只选取一次,0.5×10=5分）中文文献：1、标题：慢性阻塞性肺疾病中医药研究进展著者： 彭波； 李泽庚； 童佳兵； 杨程； 王传博； 张念志；著者单位：安徽中医学院第一附属医院呼吸科出处：辽宁中医药大学学报2011(06)中文摘要：慢性阻塞性肺疾病是临床的常见病,文章结合慢性阻塞性肺疾病近年研究成果,从中医病名范畴、病因病机、常用治法的进行综述,系统总结了近年来的中医药干预慢性阻塞性肺疾病研究进展,对应用中医药研究慢性阻塞性疾病有一定的意义。2、标题：中医药辨证治疗慢性阻塞性肺疾病稳定期随机对照试验的疗效评价指标系统评价著者： 张海龙； 王明航； 赵栋梁； 余学庆； 王海峰； 李建生；著者单位：河南中医学院第一附属医院； 河南中医学院第三附属医院； 河南中医学院老年医学研究所；出处：世界科学技术中医药现代化2013(06)中文摘要：目的:在系统评价中医药辨证治疗慢性阻塞性肺疾病(COPD)随机对照试验临床疗效基础上评述其疗效评价指标的选择和使用。方法:计算机检索CBM、CNKI、VIP、万方数据库、Cochrane图书馆、PubMed和Embase数据库,收集公开发表的中医药辨证治疗COPD随机对照试验的临床研究,由两位研究者按照纳入标准独立筛选文献、提取资料后,应用RevMan5.1软件进行Meta分析。结果:共纳入40篇随机对照试验(RCT),Meta分析结果显示中医辨证治疗能够改善患者肺功能,提高生存质量,提高临床疗效和中医证候疗效,减少急性加重次数,改善临床症状体征;疗效评价指标使用较多的有肺功能、生存质量、临床综合疗效、急性加重次数、临床症状体征、证候疗效、中医证候积分,其余如6分钟步行距离、BODE指数、卫生经济学评价则选用相对较少。结论:中医药辨证治疗COPD具有较好的临床疗效,但由于纳入研究的质量不高,仍需开展大样本、多中心、方法科学的高质量临床试验;临床疗效评价指标的选用仍不规范,疗效指标的选择应根据临床研究的目的不同而有所侧重,另外还应体现中医药的临床特点。 更多还原3、标题：中医药治疗慢性阻塞性肺疾病临床研究要点的思考著者：李建生； 余学庆著者单位：河南中医学院老年医学研究所； 河南中医学院第一附属医院；出处：中医杂志2011(21)中文摘要：慢性阻塞性肺疾病(COPD)具有较大的危害性,中医药治疗COPD具有明显的疗效,但由于缺乏较高质量的临床研究,从而影响了中医药的推广应用及深入研究。基于近年国内外相关临床试验和诊疗指南,结合国内中医药治疗COPD临床研究现状,就开展中医药治疗COPD临床研究中若干要点进行了讨论,包括研究预期目的和目标的确定、受试者的选择、试验方案设计、给药方案、临床疗效评价的结局及指标、访视与评价时间的确定、吸烟的管理、风险与获益等,以期对中医药治疗COPD临床研究有所裨益。 更多还原4、标题：慢性阻塞性肺疾病中医药研究进展著者：邱维敏； 卢兴华；著者单位：云南中医学院；出处：中国医药科学2014（04）中文摘要：慢性阻塞性肺疾病临床较为常见,属于"肺胀""咳嗽""痰饮""喘证"范畴。其基本病理特征为本虚标实,急性期以标实为急,以痰、瘀、热较为多见,稳定期以本虚为主,肺脾肾虚损为多见。目前尚缺乏理想的治疗方法,越来越多的研究证实慢性阻塞性肺疾病患者采用中医药治疗能够收到较好的效果。本文从中医药对慢性阻塞性肺疾病的基础研究及机制研究两个方面做一总结。 更多还原5、标题：慢性阻塞性肺疾病的中医药治疗进展著者：李晗； 杨德玉； 李雪苓著者单位：安徽中医药大学； 安徽中医药大学第一附属医院；出处：中医药临床杂志2014（03）中文摘要：<正>慢性阻塞性肺疾病(COPD)是一种以气流受限为特征的肺部疾病,气流受限不完全可逆,呈进行性发展,为急诊科和呼吸内科的临床常见病、多发病,是一种严重危害到人民身体健康的重大疾病。目前西医研究的病因还不十分清楚,治疗手段也以对症处理为主。现阶段,中医药在防治COPD的研究中取得了较大的进步,现就中医药治疗慢性阻塞性肺疾病作一综述。病因病机慢性阻塞性肺疾病属于中医学"咳嗽""喘证""咳喘" 更多还原英文文献：1、TI：A Microfluidic Platform for Evaluating Neutrophil Chemotaxis Induced by Sputum from COPD PatientsAU：Wu J1, Hillier C2, Komenda P2, Lobato de Faria R2, Levin D3, Zhang M4, Lin F5.· AD：1Department of Physics and Astronomy, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada; Department of Biosystems Engineering, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada.· 2Seven Oaks General Hospital, Winnipeg, MB, R2V 3M3, Canada.· 3Department of Biosystems Engineering, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada.· 4Seven Oaks General Hospital, Winnipeg, MB, R2V 3M3, Canada; Rizhao Hospital of Traditional Chinese Medicine, Rizhao, China.· 5Department of Physics and Astronomy, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada; Department of Biosystems Engineering, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada; Department of Biological Sciences, University of Manitoba, Winnipeg, MB, R3T 2N2, Canada; Department of Immunology, University of Manitoba, Winnipeg, MB, R3E 0T5, Canada.SO：2015 May 11;10(5):e0126523. doi: 10.1371/journal.pone.0126523. eCollection 2015AB：Chronic Obstructive Pulmonary Disease (COPD) is a common lung disease characterized by breathing difficulty as a consequence of narrowed airways. Previous studies have shown that COPD is correlated with neutrophil infiltration into the airways through chemotactic migration. However, whether neutrophil chemotaxis can be used to characterize and diagnose COPD is not well established. In the present study, we developed a microfluidic platform for evaluating neutrophil chemotaxis to sputum samples from COPD patients. Our results show increased neutrophil chemotaxis to COPD sputum compared to control sputum from healthy individuals. The level of COPD sputum induced neutrophil chemotaxis was correlated with the patient's spirometry data. The cell morphology of neutrophils in a COPD sputum gradient is similar to the morphology displayed by neutrophils exposed to an IL-8 gradient, but not a fMLP gradient. In competing gradients of COPD sputum and fMLP, neutrophils chemotaxis and cell morphology are dominated by fMLP. 2、TI：Role of the fixed combination of fluticasone and salmeterol in adult Chinese patients with asthma and COPDAU：Gao J1, Pleasants RA2· AD：1Department of Respiratory Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People's Republic of China.· 2Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, NC, USA.SO：2015 Apr 15;10:775-789.AB：Chronic obstructive pulmonary disease (COPD) and asthma are common airway disorders characterized by chronic airway inflammation and airflow obstruction, and are a leading cause of morbidity and mortality in the People's Republic of China. These two diseases pose a high economic burden on the family and the whole of society. Despite evidence-based Global Initiative for Chronic Obstructive Lung Disease and Global Initiative for Asthma guidelines being available for the diagnosis and management of COPD and asthma, many of these patients are not properly diagnosed or managed in the People's Republic of China. The value of combination therapy with inhaled corticosteroids and long-acting 2-agonists has been established in the management of asthma and COPD globally. Combinations of inhaled corticosteroids and long-acting 2-agonists such as fluticasone and salmeterol, have been shown to be effective for improving symptoms, health status, and reducing exacerbations in both diseases. In this review, we discuss the efficacy and safety of this combination therapy from key studies, particularly in the People's Republic of China3、TI：Prognostic value of different scoring models in patients with multiple organ dysfunction syndrome associated with acute COPD exacerbation.AU：Xiao K1Guo C1, Su L1, Yan P1, Li X1, Xie L1· AD：11 Department of Respiratory Medicine, Chinese People's Liberation Army (PLA) General Hospital, Beijing 100853, China ; 2 Department of Cardiology, Fuwai Hospital CAMS & PUMC, Beijing 100037, China ; 3 Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100032, China ; 4 Department of Internal Medicine, Chinese People's Liberation Army (PLA) General Hospital, Beijing 100853, China.SO：2015 Mar;7(3):329-36. doi: 10.3978/j.issn.2072-1439.2014.11.27AB：ACKGROUND AND OBJECTIVE: Chronic obstructive pulmonary disease (COPD) represents an increasing healthcare concern as a leading cause of morbidity and mortality worldwide. Our objective was to predict the outcome of COPD patients associated with multiple organ dysfunction syndrome (MODS) by scoring models.METHODS: A retrospective study was performed on severe COPD patients within 24 hours of the onset of MODS. The Acute Physiology and Chronic Health Evaluation (APACHE) II, APACHE III, Multiple Organ Dysfunction Score (MODS), Simplified Acute Physiology Score II (SAPS II), and Sepsis-related Organ Failure Assessment (SOFA) scores were calculated for patients.RESULTS: A total of 153 elderly patients were recruited. Compared to 30-day survivors, the number of failing organs and all of the scoring models were significantly higher in 30-day non-survivors. The SOFA showed the highest sensitivity and area under the curve (AUC) for predicting the prognosis of patients with MODS induced by acute exacerbation of COPD. The results of logistic regression indicated that factors that were correlated with the prognosis of COPD included the exacerbation history, SOFA score, number of failing organs, and duration of ICU stay. The value of exacerbation frequency for predicting the outcome of COPD was excellent (AUC: 0.892), with a sensitivity of 0.851 and a specificity of 0.797.CONCLUSIONS: The SOFA score, determined at the onset of MODS in elderly patients with COPD, was a reliable predictor of the prognosis. The exacerbation frequency, number of failing organs, and the SOFA score were risk factors of a poor prognosis, and the exacerbation frequency could also effectively predict the outcome of COPD4、TI：Effects of the Inhalation of the M3 Receptor Antagonist Bencycloquidium Bromide in A Mouse Cigarette Smoke-Induced Airway Inflammation Model.AU：Zhang SJJiang JX2, Ren QQ1, Xie QM2,3, Xiong YK1.· AD：1Department of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, 310053, China.· 2Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou, China, 310058.· 3Department of Medicine, Laboratory Animal Center of Zhejiang University, Hangzhou, China, 310058.SO：2015 May 11. doi: 10.1002/ddr.21248. Epub ahead of printAB：Preclinical Research Bencycloquidium bromide (BCQB), a novel M3 receptor antagonist, alleviates airway hyperresponsiveness, inflammation, and airway remodeling in a murine model of asthma. The aim of this study was to investigate the anti-inflammatory activity of inhaled BCQB in a cigarette smoke (CS)-induced model of acute lung inflammation. Mice exposed to CS developed chronic obstructive pulmonary disease (COPD). Inhalation of BCQB suppressed the accumulation of neutrophils and macrophages in airways and lung and also inhibited the CS-induced increases in mRNA levels of keratinocyte-derived chemokine, monocyte chemotactic protein-1, tumor necrosis factor-alpha, and interleukin-1 in lung and protein expression levels in bronchoalveolar lavage fluid. Moreover, BCQB (300 g/ml) inhibited the CS-induced changes in superoxide dismutase and myeloperoxidase activities in the lungs. Our study suggests that BCQB might be a potential therapy for inflammation in CS-induced pulmonary diseases, including COPD. Drug Dev Res, 2015. © 2015 Wiley Periodicals, Inc.5、TI：Gene susceptibility identification in a longitudinal study confirms new loci in the development of chronic obstructive pulmonary disease and influences lung function decline.AU：Xie J1, Wu H2, Xu Y3, Wu X4, Liu X5, Shang J6, Zhao J7, Zhao J8Wang J9,10, Dela Cruz CS11, Xiong W12, Xu Y· AD：1Department of Respiratory and Critical Care Medicine, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. xiejjgg.· 2Department of Respiratory and Critical Care Medicine, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. wuhongxu_tj.· 3Department of Respiratory and Critical Care Medicine, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. xuyuzhu_tj.· 4Department of Respiratory and Critical Care Medicine, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. wuxiaojie-tj.· 5Department of Respiratory and Critical Care Medicine, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. liuxue_tj.· 6Department of Respiratory and Critical Care Medicine, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. shangjin_tj.· 7Department of Respiratory and Critical Care Medicine, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. jpzhaotj.· 8Department of Respiratory and Critical Care Medicine, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. zhaojunling-tj.· 9Department of Respiratory and Critical Care Medicine, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. mailtooth.· 10Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, USA. mailtooth.· 11Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, USA. charles.delacruzyale.edu.· 12Department of Respiratory and Critical Care Medicine, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. wnxiong_tj.· 13Department of Respiratory and Critical Care Medicine, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. yjxutj.SO：2015 Apr 18;16(1):49. doi: 10.1186/s12931-015-0209-3.AB：BACKGROUND: To identify COPD associated gene susceptibility and lung function in a longitudinal cohort including COPD and subjects who were at risk for developing COPD, and to replicate this in two cross-sectional and longitudinal populations in Chinese Han population.METHODS: Three cohorts were recruited in this study, including an 18-year follow-up population (306 COPD and 743 control subjects) in one village in 1992 and it changed to 409 COPD and 611 controls in 2010, a 2 year follow-up study in another village (374 COPD and 377 controls) and another 2 year follow-up one in a city (541 COPD and 560 controls) in 2010. Sixteen candidate single nucleotide polymorphisms (SNPs) were selected for genotyping. Among them, 5SNPs in or near HHIP, 1SNP in IREB2 and 1SNP in FAM13A were previously reported to be associated with COPD susceptibility or lung function decline. And another 9SNPs were selected from HapMap website as HHIP tags. In 2010, totaling 1,324 COPD patients and 1,548 healthy controls were finally included in our genetic susceptibility analyses.RESULTS: We identified two new regions showing an association with COPD susceptibility in the Human Hedgehog interacting protein (HHIP) rs11100865 and rs7654947, and we confirmed that the family with sequence similarity 13 member A gene (FAM13A) rs7671167 was associated with the development of COPD in Chinese Han population. And the HHIP rs7654947 and FAM13A rs7671167 were associated with