最新医学免疫学第六章 细胞因子幻灯片.ppt

l细胞因子细胞因子(Cytokine,CK) 是由免疫原、丝裂原或其他因是由免疫原、丝裂原或其他因子刺激细胞所产生的低分子量可溶子刺激细胞所产生的低分子量可溶性蛋白质，为生物信息分子，具有性蛋白质，为生物信息分子，具有调节免疫应答等多种功能。调节免疫应答等多种功能。l其他名称：其他名称：monokine, lymphokine, colony stimulating factor概念概念商品名商品名性质性质临床应用临床应用EmbrelChimeric TNF-Rr/IgG constant regionRheumatoid arthritisRemicade or HumiraMcAb against TNF-a a receptorRA, Crohns diseaseRoferonIFN-a a-2aHepatitis B, Hairy-cell leukemia, Kaposis sarcomaIntron AIFN-a a-2bHepatitis C, MelanomaBetaseronIFN-b b-1bMultiple sclerosisAvonexIFN-b b-1aMultiple sclerosisActimmuneIFN-g g-1b bChronic granulomatous disease, OsteopetrosisNeupogenG-CSFStimulates production of neutrophils after chemotherapy, AIDS patientsLeukineGM-CSFStimulates production of myeloid cells after bone marrow transplantationNeumega or NeulastaIL-11Stimulates production of plateletsEpogenErythopoietinStimulates red-blood-cell productionbackbackbackbackbackbackback18 结束语结束语