关于芬必得（布洛芬）临床研究进展About Fenbid (ibuprofen) clinical research progress.doc

药理学(论文)课 题 名 称 关于芬必得（布洛芬）临床研究进展 学 生 姓 名 学 号 1 0 4 0 9 0 3 0 0 4 系、年级专业 生物与化学工程系10级生物工程班 指 导 教 师 About Fenbid (ibuprofen) clinical research progress Abstract: In order to understand the variety of clinical performance Fenbid drugs, clinical treatment of different diseases in the application Fenbid mechanism of action of the drugs, anti-inflammatory, analgesic, antipyretic drugs. The Fenbid drugs in the treatment of rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, neuritis symptoms have a good effect.Keywords: ibuprofen; osteoarthritis; antipyretic analgesic; interaction 关于芬必得（布洛芬）临床研究进展 摘要：为了了解芬必得药物的各种临床效能，通过不同的疾病临床治疗在应用芬必得药物的作用机制，可以确定此药物有抗炎、镇痛、解热等作用。芬必得药物在治疗风湿性关节炎、类风湿性关节炎、骨关节炎、强直性脊椎炎和神经炎等症状都有很好的效果。关键词：布洛芬；骨关节炎；解热镇痛；相互作用1. Fenbid introduction1.1 Chemical compositionThe main ingredient is ibuprofen, the chemical name of 2 - (4 - isobutylphenyl) propionic acid, molecular weight of 206.28.1.2 Domestic productsFenbid Ibuprofen Sustained Release Capsules, Fenbid creams, headache mounted Fenbid, phenol coffee piece Fenbid (Fenbid new headache installed)1.3 Mechanism of actionIbuprofen by inhibiting inducible induced inflammatory cyclooxygenase metabolism of arachidonic media prostaglandins or other neurotransmitter synthesis, reducing the prostaglandin-induced local tissue congestion, swelling, fever1; inhibit leukocyte activity and dissolvedenzyme releasing reduce the partial sciatic nerve pain sensitivity, reduce the pain caused by substances such as bradykinin organizational impulse analgesic effect2. Ibuprofen for the treatment of dysmenorrhea mechanism may be the inhibition of prostaglandin pressure drop within the uterus, contractions reduce.By anti-inflammatory, analgesic ibuprofen can relieve gout3.2. Fenbid drug metabolismEasy absorption of oral ibuprofen, slow absorption with food and clothes, but does not affect the uptake, plasma protein binding rate (the percentage of drug in the plasma in the plasma protein binding) of 99%4, 1.22.1 hours after taking the bloodthe peak plasma concentration, synovial fluid concentrations equal to the plasma concentration after 5 hours, within 12 hours after the synovial fluid concentrations higher than plasma concentrations.The half-life (drug plasma concentrations decreased from the highest value it takes for half of the time) typically 1.82 hours5 6. 60% 90% in the liver metabolism, 24 hour urine excreted by the kidneys.3. Fenbid major clinical application of the drug3.1 For the treatment of common orthopedic conditionsIbuprofen for the pain caused by rheumatic and rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout, the effect is more ideal7. Of short duration, the symptoms of mild to moderate cases, ibuprofen very good effect in suppressing pain, while also significantly improve patient morning stiffness, joint swelling, limited mobility and other symptoms. And for a longer duration, symptoms of severe cases of efficacy is relatively low, especially of certain classes arthritis, rheumatoid arthritis late, many joint deformity and joint gap narrowed significantly poorer treatment outcomes. Ibuprofen for lumbar disc herniation, lumbar spinal stenosis, lumbar muscle strain, muscle fasciitis and sciatic nerve Yandeng various causes of low back pain, neck type or nerve root type cervical spondylosis, muscle fasciitis, inflammation of ligaments causes such as neck and shoulder pain, frozen shoulder efficacy. However, for the pain caused by nerve compression effect is not ideal.3.2 Used for analgesia8Less than morphine, the analgesic effect of ibuprofen analgesics meperidine (Demerol), traumatic pain, visceral smooth muscle cramps are invalid. But have a good effect on the chronic dull headache, toothache, joint pain, muscle pain, and dysmenorrhea. And low toxicity, no addiction, it is widely used.3.3 OtherHuang Yuhua reports of delayed cerebral vasospasm after treatment of subarachnoid hemorrhage plus ibuprofen can improve efficacy. Domestic animal experiments confirmed that the preventive effect of ibuprofen on the treatment of acute lung injury. In recent years, the test results show that the domestic and international use ibuprofen treatment of premature children with acute lung injury, it does not affect the brain, mesenteric and renal blood flow. In addition, ibuprofen can make the the febrile patients body temperature dropped to normal, but had no significant effect on normal human body temperature.4.Common side effects Fenbid drug use9The more common side effects of nausea, vomiting ibuprofen. The most common skin reaction itching, and may occur rash, drug eruptions, and photosensitivity dermatitis, hair loss.Rare heartburn, epigastric pain, gastrointestinal erosions, can cause acute gastrointestinal bleeding10. Ibuprofen caused stomach and duodenal mucosal injury and incidence is much lighter than aspirin, irritation of the gastrointestinal tract is also much smaller than other general anti-inflammatory drugs.5. Fenbid the interaction of the drug with other drugs11With aspirin, aspirin may reduce the role of the prevention and treatment of myocardial infarction and cerebral infarction; complemented by conventional arthritis treatment glucosamine helps to strengthen, there may be a corresponding reduction in the dose of ibuprofen ibuprofen pain relief efficacy andupset stomach side effects of taking the drug; drug use increase the risk of bleeding with heparin, dicoumarol anticoagulant and platelet aggregation inhibition; latter down with the use of antihypertensive drugsThe pressure effect. And so on.Conclusion(1) Fenbid for various causes of non-infectious inflammation reliable anti-inflammatory effects and achieve a good anti-inflammatory and analgesic effect of swelling and restore joint function;(2) ibuprofen as an antipyretic analgesic, more and more attention of the medical profession, as a family standing drug has a very good development prospects.References1 Du Dongping, the Sun Guoqin, Xu Enfang. Ibuprofen on cellular immune function of traumatized mice. Anesthesiology, 1999; 19 (8): 472 Bley K RT he role of IP the prost anoidrecept ors in inf lammat is ory pain.T IPS.1998; 19:1413 European security Juan Chen Yuanliang clinical observation of treatment of 110 cases of primary dysmenorrhea. Medicine September 2009 Volume 4 No. 264 Evans A M.Pharmacodynamics andpharmacokinetics of t he profens: enantioselect ivity Clinical implicat ionsand Special Ref-erence to the S (+)-ibuprof en.J. 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