(完整word版)第一章药理学总论-绪言.pdf

第一章药理学总论绪言授课时间2010 年 3 月 8 日授课对象临床医学 2008级 16 班授课教师喻泽兰授课时数：1 学时目的和要求：1.掌握药理学概念及研究内容；2.熟悉药物的概念、药理学的学科地位；3.了解药理学分支学科、新药研究与开发。重点难点：重点：1药动学、药效学；2药理学在医学中的地位与作用。难点：药动学与药效学的区别。教学内容：第一章绪言(Introduction)一、药理学的性质与任务1、基本概念（1）药物(drugs)概念：能影响器官生理功能和/或细胞代谢，改变或查明病理状态，用于预防、诊断、治疗疾病及计划生育的化学物质。来 源：Ancient:Natural productsPlants（罂粟公元 16 世纪开始用于镇痛、止咳、催眠等）Animals（海洋动物海狗肾）Minerals（绿盐、芒硝）Modern:天然产物的提取物（吗啡）化学方法制备的合成化合物（安定、杜冷丁）生物 工 程 技术 获 得 的 产 品（干 扰 素、疫 苗），基因重组技术获得的产品（人工合成胰岛素）文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4毒物(toxicant;poison)小剂量对机体就能产生毒害作用的化学物质。食物药物毒物（2）药理学(pharmacology)概念：研究药物与机体（含病原体）间相互作用及作用规律的一门学科。药理学为防治疾病合理用药提供基本理论、基本知识和科学的思维方法。“pharmacology”一词，在语源学上由希腊文pharmakon（药物、毒物）和logos（道理）缩合演变而成。pharmacology=药物（毒物）道理药物效应动力学（Pharmacodynamics）：研究药物的作用、作用机制。药物代谢动力学（Pharmacokinetics）：研究药物在体内的吸收、分布、代谢、排泄，血药浓度随时间的变化过程学科任务：1.阐明药物作用及作用机制，帮助医药卫生工作者正确地合理用药，发挥药物的治疗效果，防治不良反应；文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D42.研究开发新药，发现药物新用途3.为阐明生物机体的生物化学及生理学现象提供重要的科学资料二药物与药理学的发展史(Historical Highlights)1.本草与草医草药学的贡献本草纲目2.现代药理学的形成与发展18 世纪末19 世纪3.现代药理学的快速发展与分支学科20 世纪 30 年代后“本 草 纲 目”（Compendium of Materia Medica):历时 27年,明末 1578年完成，共 52 卷，190万字,收药 1892种，插图 1160幅，药方 11000条。英、日、德、俄、法、拉丁7 种文字。药理学的发展史由本草阶段，随着生理、生化等生命科学的发展，以及有机化学等工具学科的发展，逐渐发展为一门独立学科，并向纵深发展，形成一些分支学科，如生化药理学、分子药理学、临床药理学等。研究水平：由器官药理学深入到分子药理学；由分支学科 交叉学科的形成。文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4三.新药开发与研究：新药：化学结构、药品组分或药理作用不同于现有药品的药物。我国未生产过的药品；已生产过的药品改变剂型、给药途径、增加新适应症或新复方制剂。新药研究程序：1.临床前研究药学研究：工艺路线、理化性质、质量标准、稳定性药理学研究：药效学、药动学及一般药理学研究毒理学研究：急毒、慢毒、特殊毒性研究2.临床研究：一期临床，二期临床，三期临床3.上市后药物监测（四期临床，售后调研）新药开发现况：目前，计算机辅助药物设计与辅助药物筛选已成为各国制药公司研究开发的主要手段之一。据 Bayer 公司统计，现在每10 万个化合物最多可筛选出 10 个有研究与开发价值的先导化合物。Zeneca公司统计近 10年初筛的 19.7万个化合物中有103 个活性较好的先导化合物具有深入研究开发的价值，文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4最后仅有 8 个先导化合物开发成为新药进入市场。Glaxo Wellcom 公司现在每年要筛选几十万个化合物，从而获得十几个先导化合物。文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4文档编码:CN5U3V1Y1I2 HI2H2H10S10D8 ZZ4V5O9G9D4