2021年药化练习题及答案.pdf

药化练习题及答案109 1/26 药物化学练习题第 1 章单项选择题：1-1、巴比妥类药物的药效主要与下列哪个因素有关（E）A.分子的大小和形状B.1-位取代基的改变C.分子的电荷分布密度D.取代基的立体因素E.药物在体内的稳定性1-2、巴比妥类药物pKa 值如下，哪个显效最快（C）A.戊巴比妥，pKa8.0（未解离常数75%）B.丙烯巴比妥，pKa7.7（未解离常数66%）C.己锁巴比妥，pKa8.4（未解离常数90%）D.苯巴比妥，pKa7.9（未解离常数50%）E.异戊巴比妥，pKa7.9（未解离常数75%）1-3 抗精神失常药从化学结构主要分为（D）A.吩噻嗪类、巴比妥类、氨基甲酸类和其它类B.吩噻嗪类、巴比妥类、派啶醇类和其它类C.1,2-苯并氮杂?类、硫杂蒽类（噻吨类）、丁酰苯类和其它类D.吩噻嗪类、硫杂蒽类（噻吨类）、丁酰苯类、苯二氮杂?类和其它类E.巴比妥类、硫杂蒽类（噻吨类）、丁酰苯类、苯二氮杂?类和其它类1-4、海索巴比妥属哪一类巴比妥药物（D）A.超长效类(8 小时)B.长效类(6-8 小时)C.中效类(4-6 小时)D.超短效类(1/4 小时)1-5、巴比妥药物5 位取代的碳原子数超过8 个（C）A.迅速产生作用，可作为麻醉前给药，但维持时间短B.作为长效药C.产生惊厥作用D.维持作用时间短E.产生催眠作用比较迟缓精品w o r d 学习资料 可编辑资料-精心整理-欢迎下载-第 1 页，共 26 页药化练习题及答案109 2/26 1-6、巴比妥药物2 位羰基氧原子被硫原子取代（A）A.迅速产生作用，可作为麻醉前给药，但维持时间短B.作为长效药C.产生惊厥作用D.维持作用时间短E.产生催眠作用比较迟缓1-7、巴比妥药物5 位用苯或饱和烃取代（B）A.迅速产生作用，可作为麻醉前给药，但维持时间短B.作为长效药C.产生惊厥作用D.维持作用时间短E.产生催眠作用比较迟缓1-8、巴比妥药物pKa 较小，易解离（E）A.迅速产生作用，可作为麻醉前给药，但维持时间短B.作为长效药C.产生惊厥作用D.维持作用时间短E.产生催眠作用比较迟缓1-9、巴比妥药物5 位用烯烃取代（D）A.迅速产生作用，可作为麻醉前给药，但维持时间短B.作为长效药C.产生惊厥作用D.维持作用时间短E.产生催眠作用比较迟缓1-10、短效巴比妥类镇静催眠药（D）A.奋乃静B.舒必利C.氟哌丁醇D.硫喷妥钠E.氯普噻吨1-11、丁酰苯类抗精神病药（C）A.奋乃静B.舒必利精品w o r d 学习资料 可编辑资料-精心整理-欢迎下载-第 2 页，共 26 页文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3药化练习题及答案109 3/26 C.氟哌丁醇D.硫喷妥钠E.氯普噻吨1-12、苯甲酰胺类抗精神病药（B）A.奋乃静B.舒必利C.氟哌丁醇D.硫喷妥钠E.氯普噻吨1-13、硫杂蒽类抗精神病药（E）A.奋乃静B.舒必利C.氟哌丁醇D.硫喷妥钠E.氯普噻吨1-14、吩噻嗪类抗精神病药（A）A.奋乃静B.舒必利C.氟哌丁醇D.硫喷妥钠E.氯普噻吨1-15、下列为抗躁狂药的结构是（E）A.B.C.D.E.以上都不是多项选择题：1-16 巴比妥药物的代谢途径（BDE）A.脱氧B.5 位取代基氧化C.氨基氧化D.水解开环E.氮上脱烷基精品w o r d 学习资料 可编辑资料-精心整理-欢迎下载-第 3 页，共 26 页文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3药化练习题及答案109 4/26 1-17 影响巴比妥药类物镇静催眠作用强弱、起效快慢和时间长短的因素（ABCDE）A.pKa B.脂水分配系数C.5 位取代基的种类D.1 位氮上是否有甲基取代E.2 位氧是否被硫取代1-18 巴比妥药物的药效主要受哪些因素影响（AC）A.有适当的脂溶性B.水中溶解度C.5 位二取代基的碳原子数在610 之间D.分子 1 位上的取代基E.药物电荷密度分布1-19 吩噻嗪类药物药效主要受那些因素影响（ACD）A.侧链末端的碱氨基是哌嗪时，活性极大增加B.当 7 位有强吸电子基存在时，活性增加C.2 位被吸电子基氯、三氟甲基取代，抗精神病活性增加D.10 位氮原子上与侧链碱氨基之间的碳链像个三个原子为宜E.侧链末端的碱氨基是季铵时，活性极大增加1-20 下列药物属于吩噻嗪类抗精神失常药的是（BD）A.硝西泮B.氯丙嗪C.阿米替林D.奋乃静E.三氟哌多1-21、为抗精神病药物的结构是（AB）A.B.C.D.精品w o r d 学习资料 可编辑资料-精心整理-欢迎下载-第 4 页，共 26 页文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3药化练习题及答案109 5/26 E.1-22、下列关于吩噻嗪类药物构效关系的叙述正确的是（ABCDE）A.吩噻嗪母核是基本结构；母核氮上原子与侧链上碱性基团R1 间隔 3 个碳原子B.2 位取代基引起分子的不对称性，优势构象中侧链向含有2 位取代的苯环倾斜是这类药物抗精神病作用的重要特征C.R1 常为碱性的叔胺基团，如二甲氨基，哌嗪或哌啶D.2位 有 吸 电 子 基 取 代，其 吸 电 子 能 力 强 弱 与 抗 精 神 病 作 用 成 正 比，如CF3ClCOCH3HOH E.吩噻嗪母核硫原子可以被-O-、-CH2-、-CH=CH-、-CH2CH2-等电子等排体取代；母核上 N 原子被-C=取代，衍生出噻吨类抗精神病药。第 二 章单项选择题：2-1、下列药物中那个药物不溶于NaHCO3溶液中（B）A.布洛芬B.对乙酰氨基酚C.双氯芬酸D.萘普生E.酮洛芬2-2、具有下列化学结构的药物是（E）HH3CCH3OONOOOA.阿司匹林B.安乃近C.吲哚美辛D.对乙酰氨基酚E.贝诺酯2-3、下列哪个药物具有手性碳原子，临床上使用S-（+）异构体（D）A.安乃近B.双氯芬酸钠C.吡罗昔康昔布D.萘普生E.保泰松2-4、临床上使用的布洛芬为何种异构体（D）A.左旋体B.右旋体精品w o r d 学习资料 可编辑资料-精心整理-欢迎下载-第 5 页，共 26 页文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3药化练习题及答案109 6/26 C.内消旋体D.外消旋体E.30%的左旋体和70%右旋体混合物。2-5、对乙酰氨基酚的哪一个代谢产物可导致肝坏死（D）A.葡萄糖醛酸结合物B.硫酸酯结合物C.氮氧化物D.N-乙酰基亚胺醌E.谷胱甘肽结合物2-6、增加粒细胞吞噬尿酸盐晶体（A）A.秋水仙碱B.阿司匹林C.别嘌醇D.丙磺舒E.吲哚美辛2-7、抑制黄嘌呤氧化酶（C）A.秋水仙碱B.阿司匹林C.别嘌醇D.丙磺舒E.吲哚美辛2-8、抗痛风性急性关节炎发作（E）A.秋水仙碱B.阿司匹林C.别嘌醇D.丙磺舒E.吲哚美辛2-9、增加尿酸排泄（D）A.秋水仙碱B.阿司匹林C.别嘌醇D.丙磺舒E.吲哚美辛多项选择题：2-10、对扑热息痛的正确描述是（ABDE）A.水溶液放置时可发生氧化分解B.具有解热镇痛作用C.具有抗炎作用D.与阿司匹林成酯得贝诺酯E.是花生四烯酸环氧合酶的不可逆抑制剂2-11、下列哪些性质与布洛芬的性质相符（ADE）A.在有机溶剂中易溶B.在酸性水溶液中易溶C.结构中不含羧基D.临床用外消旋体E.适用于风湿性关节炎2-12、下列药物中，具有手性碳原子的是（BC）A.对乙酰氨基酚B.萘普生C.布洛芬D.地西泮E.苯巴比妥精品w o r d 学习资料 可编辑资料-精心整理-欢迎下载-第 6 页，共 26 页文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3药化练习题及答案109 7/26 第 三 章单项选择题3-1、下列与吗啡及合成镇痛药化学结构特点不符合的是（C）A.含有派啶环或类似派啶环的空间结构B.分子中具有一个平坦的芳环平面C.碱性中心在芳环平面的垂直方向D.烃基链部分（吗啡结构中C15/C16）突出于平面前方E.一个碱性中心，并在生理PH 条件下能电离为阳离子3-2、吗啡结构中有（A）A.5 个手性碳B.2 个手性碳C.3 个手性碳D.4 个手性碳E.1 个手性碳3-3、属于派啶类合成镇痛药的是（C）A.美沙酮B.纳洛酮C.哌替啶D.喷他佐辛E.萘福泮3-4、属于氨基酮类合成镇痛药的是（E）A.二醋吗啡（海洛因）B.羟考酮C.埃托啡D.纳洛酮E.美沙酮3-5、吗啡及合成镇痛药具有镇痛活性，这是因为（D）A.具有相似的疏水性B.具有相似的立体结构C.具有完全相同的构型D.具有相同的药效构象E.化学结构相似3-6、(-)-吗啡分子结构中手性碳原子为（D）A.C-5 C-6 C-10 C-13 C-14 B.C-4 C-5 C-8 C-9 C-14 C.C-5 C-6 C-9 C-10 C-14 D.C-5 C-6 C-9 C-13 C-14 E.C-6 C-9 C-10 C-13 C-14 3-7、(-)-吗啡分子结构中B/C 环、C/D 环、C/E 环的构型为为（C）A.B/C 环成呈顺式、C/D 环呈反式、C/E 环呈反式B.B/C环成呈反式、C/D环呈反式、C/E环呈反式C.B/C 环成呈顺式、C/D 环呈反式、C/E 环呈顺式D.B/C 环成呈顺式、C/D 环呈顺式、C/E 环呈顺式E.B/C 环成呈反式、C/D 环呈顺式、C/E 环呈顺式精品w o r d 学习资料 可编辑资料-精心整理-欢迎下载-第 7 页，共 26 页文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:CN10O7S4X8H6 HG4V8C5U2R7 ZP1J6W9Y9M3文档编码:C