英文论文投稿信Cover letter 模板.pdf
-.英文论文投稿信英文论文投稿信 CoverCoverletterletter 模板模板qiusuo BY-2006-1-17 8:59:00Dear Editor,We would like to submit the enclosed manuscript entitled GDNF Acutely Modulates NeuronalExcitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons,which we wish tobe considered for publication in Nature Neuroscience.GDNF has long been thought to be a potent neurotrophic factor for the survival of midbraindopaminergic neurons,which are degenerated in Parkinson s disease.In this paper,we report anunexpected,acute effect of GDNF on A-type potassium channels,leading to a potentiation ofneuronal excitability,in the dopaminergic neurons in culture as well as in adult brain slices.Further,we show that GDNF regulates the K+channels through a mechanism that involves activation of MAPkinase.Thus,this study has revealed,for the first time,an acute modulation of ion channels byGDNF.Our findings challenge the classic view of GDNF as a long-term survival factor for midbraindopaminergic neurons,and suggest that the normal function of GDNF is to regulate neuronalexcitability,and consequently dopamine release.These results may also have implications in thetreatment of Parkinsons disease.Due to a direct petition and conflict of interest,we request that Drs.XXX of HarvardUniv.,and YY ofYale Univ.not be considered as reviewers.With thanks for your consideration,I amSincerely yours,case2case2Dear Editor,We would like to submit the enclosed manuscript entitled Ca2+-binding protein frequenin mediatesGDNF-induced potentiation of Ca2+channels and transmitter release,which we wish to beconsidered for publication in Neuron.We believe that two aspects of this manuscript will make it interesting to general readers of Neuron.First,we report that GDNF has a long-term regulatory effect on neurotransmitter release at theneuromuscular synapses.This provides the first physiological evidence for a role of this new familyof neurotrophic factors in functional synaptic transmission.Second,we show that the GDNF effect ismediated by enhancing the expression of the Ca2+-binding protein frequenin.Further,GDNF andfrequenin facilitate synaptic transmission by enhancing Ca2+channel activity,leading to anenhancement of Ca2+influx.Thus,this study has identified,for the first time,a molecular target thatmediates the long-term,synaptic action of a neurotrophic factor.Our findings may also have generalimplications in the cell biology of neurotransmitter release.0630投稿写作某杂志给出的标准Sample Cover Letterthe example used is the IJEB-.可修编.-.Case 3Sample Cover Letterthe example used is the IJEBDear Editor of the please type in journal title or acronym:Enclosed is a paper,entitled Mobile Agents for Network Management.Please accept it as acandidate for publication in the journal title.Below are our responses to your submissionrequirements.1.Title and the central theme of the article.Paper title:Mobile Agents for Network Management.This study reviews the concepts of mobileagents and distributed network management system.It proposes a mobile agent-basedimplementation framework and creates a prototype system to demonstrate the superior performanceof a mobile agent-based network over the conventional client-server architecture in a large networkenvironment.2.Which subject/theme of the Journal the material fitsNew enabling technologies(if no matching subject/theme,enter Subject highly related to subject ofjournal but not listed by please type in journal title or acronym)3.Why the material is important in its field and why the material should be published in please typein journal title or acronym?The necessity of having an effective puter network is rapidly growing alongside the implementationof information technology.Finding an appropriate network management systemhas bee increasingly important todays distributed environment.However,the conventionalcentralized architecture,which routinely requests the status information of local units by the centralserver,is not sufficient to manage the growing requests.Recently,a new framework that usesmobileagent technology to assist the distributed management has emerged.The mobile agent reducesnetwork traffic,distributes management tasks,and improves operational performance.Given todaysbandwidth demand over the Internet,it is important for the journal title/acronym readersto understand this technology and its benefits.This study gives a real-life example of how to usemobile agents for distributed network management.It is the first in the literature that reports theanalysis of network performance based on an operational prototype of mobile agent-baseddistributednetwork.We strongly believe the contribution of this study warrants its publication in the journal-.可修编.-.title/acronym.4.Names,addresses,and email addresses of four expert referees.Prof.Dr.William GatesChair Professor of Information Technology321 Johnson HallPremier University Lancaster,NY 00012-6666,USAphone:+1-888-888-8888-fax:+1-888-888-8886:wgateslancaster.eduExpertise:published a related paper(TCP/IP and OSI:Four Strategies for Interconnection)in CACM,38(3),pp.188-198.Relationship:I met Dr.Gate only once at a conference in 1999.I didnt know him personally.Assoc Prof.Dr.John AdamsDirector of Network Research CenterCollege of Business Australian University123,Harbor Drive Sydney,Australia 56789phone:+61-8-8888-8888-fax:+61-8-8888-8886:jadamsau.edu.auExpertise:published a related paper(Creating Mobile Agents)in IEEE TOSE,18(8),pp.88-98.Relationship:None.I have never met Dr.Adams.Assoc Prof.Dr.Chia-Ho ChenChair of MIS DepartmentCollege of ManagementOpen University888,Putong RoadKeelung,Taiwan 100phone:+886-2-8888-8888-fax:+886-2-8888-8886:chchenou.edu.twExpertise:published a related paper(Network Management for E-merce)in IJ Electronic Business,1(4),pp.18-28.Relationship:Former professor,dissertation chairman.Mr.Frank YoungPartner,ABC Consulting888,Seashore HighwayWon Kok,KowloonHong Kongphone:+852-8888-8888-fax:+852-8888-8886:fyoungabcc.Expertise:Mr.Young provides consulting services extensively to his clients regarding networkmanagement practices.Relationship:I have worked with Mr.Young in several consulting projects in the past three years.Finally,this paper is our original unpublished work and it has not been submitted to any otherjournal for reviews.-.可修编.-.Sincerely,Johnny SmithCase 1Dear Editor,We would like to submit the enclosed manuscript entitled GDNF Acutely Modulates NeuronalExcitability and A-type Potassium Channels in Midbrain Dopaminergic Neurons,which we wish to be considered forpublication in Nature Neuroscience.GDNF has long been thought to be a potent neurotrophic factor for the survival ofmidbrain dopaminergic neurons,which are degenerated in Parkinsons disease.In this paper,we report anunexpected,acute effect of GDNF on A-type potassium channels,leading to a potentiation of neuronal excitability,inthe dopaminergic neurons in culture as well as in adult brain slices.Further,we show that GDNF regulates the K+channels through a mechanism that involves activation of MAP kinase.Thus,this study has revealed,for the firsttime,an acute modulation of ion channels by GDNF.Our findings challenge the classic view of GDNF as a long-termsurvival factor for midbrain dopaminergic neurons,and suggest that the normal function of GDNF is to regulateneuronal excitability,and consequently dopamine release.These results may also have implications in the treatmentof Parkinsons disease.Due to a direct petition and conflict of interest,we request that Drs.XXX of HarvardUniv.,andYY of Yale Univ.not be considered as reviewers.With thanks for your consideration,I am Sincerely yours,case2DearEditor,We would like to submit the enclosed manuscript entitled Ca2+-binding protein frequenin mediatesGDNF-induced potentiation of Ca2+channels and transmitter release,which we wish to be considered forpublication in Neuron.We believe that two aspects of this manuscript will make it interesting to general readers ofNeuron.First,we report that GDNF has a long-term regulatory effect on neurotransmitter release at theneuromuscular synapses.This provides the first physiological evidence for a role of this new family of neurotrophicfactors in functional synaptic transmission.Second,we show that the GDNF effect is mediated by enhancing theexpression of the Ca2+-binding protein frequenin.Further,GDNF and frequenin facilitate synaptic transmission byenhancing Ca2+channel activity,leading to an enhancement of Ca2+influx.Thus,this study has identified,for thefirst time,a molecular target that mediates the long-term,synaptic action of a neurotrophic factor.Our findings mayalso have general implications in the cell biology of neurotransmitter release.0630 投稿写作某杂志给出的标准Sample Cover Letterthe example used is the IJEBCase 3Sample Cover Letterthe example used is the IJEB DearEditor of the please type in journal title or acronym:Enclosed is a paper,entitled Mobile Agents for NetworkManagement.Please accept it as a candidate for publication in the journal title.Below are our responses to yoursubmission requirements.1.Title and the central theme of the article.Paper title:Mobile Agents for NetworkManagement.This study reviews the concepts of mobile agents and distributed network management system.Itproposes a mobile agent-based implementation framework and creates a prototype system to demonstrate thesuperior performance of a mobile agent-based network over the conventional client-server architecture in a largenetwork environment.2.Which subject/theme of the Journal the material fits New enabling technologies(if nomatching subject/theme,enter Subject highly related to subject of journal but not listed by please type in journaltitle or acronym)3.Why the material is important in its field and why the material should be published in pleasetype in journal title or acronym?The necessity of having an effective puter network is rapidly growing alongside theimplementation of information technology.Finding an appropriate network management system has bee increasinglyimportant todays distributed environment.However,the conventional centralized architecture,which routinelyrequests the status information of local units by the central server,is not sufficient to manage the growing requests.Recently,a new framework that uses mobile agent technology to assist the distributed management has emerged.The mobile agent reduces network traffic,distributes management tasks,and improves operational performance.Given todays bandwidth demand over the Internet,it is important for the journal title/acronym readers to-.可修编.-.understand this technology and its benefits.This study gives a real-life example of how to use mobile agents fordistributed network management.It is the first in the literature that reports the analysis of network performancebased on an operational prototype of mobile agent-based distributed network.We strongly believe the contribution ofthis study warrants its publication in the journal title/acronym.4.Names,addresses,and email addresses of fourexpert referees.Prof.Dr.William Gates Chair Professor of Information Technology 321 Johnson Hall PremierUniversityLancaster,NY00012-6666,USAphone:+1-888-888-8888-fax:+1-888-888-8886:wgateslancaster.eduExpertise:published a related paper(TCP/IP and OSI:Four Strategies for Interconnection)inCACM,38(3),pp.188-198.Relationship:I met Dr.Gate only once at a conference in 1999.I didnt know himpersonally.Assoc Prof.Dr.John Adams Director of Network Research Center College of Business AustralianUniversity 123,Harbor Drive Sydney,Australia 56789 phone:+61-8-8888-8888-fax:+61-8-8888-8886:jadamsau.edu.auExpertise:published a related paper(Creating Mobile Agents)in IEEE TOSE,18(8),pp.88-98.Relationship:None.I have never met Dr.Adams.Assoc Prof.Dr.Chia-Ho Chen Chair of MIS Department College ofManagement Open University 888,Putong Road Keelung,Taiwan 100 phone:+886-2-8888-8888-fax:+886-2-8888-8886:chchenou.edu.twExpertise:published a related paper(Network Management for E-merce)inIJ Electronic Business,1(4),pp.18-28.Relationship:Former professor,dissertation chairman.Mr.Frank YoungPartner,ABC Consulting 888,Seashore Highway Won Kok,Kowloon Hong Kong phone:+852-8888-8888-fax:+852-8888-8886:fyoungabcc.Expertise:Mr.Young provides consulting services extensively to his clients regardingnetwork management practices.Relationship:I have worked with Mr.Young in several consulting projects in the pastthree years.Finally,this paper is our original unpublished work and it has not been submitted to any other journal forreviews.Sincerely,-.可修编.
