肿瘤干细胞-分子诊断与靶向治疗优秀PPT.ppt

Cancer Stem Cells,Molecular Diagnosis and Targeted TherapyFrequently Asked Questions(FAQ)What are cancer stem cells?Why is research on cancer stem cells important?In what tumor types have cancer stem cells been identified?How are cancer stem cells identified?What happens after stem cells are identified?Are clinical treatments available now to target cancer stem cells?1.What are cancer stem cells(CSC)?a selectively endowed tumori-genic capacityto recreate the full repertoire of cancer cells of the parental tumorthe expression of a distinctive repertoire of surface biomarkers2.Why is research on cancer stem cells important?weedweed rootcancercancercancercancer-No prairie fire can destroy the grass,it shoots up again with the spring breeze blows.cancer stem cells3.In what tumor types have cancer stem cells been identified?nLeukemia Stem CellsnBreast Cancer Stem Cells nHead and Neck Cancer Stem Cells nAdrenal Cancer Stem Cells nPancreatic Cancer Stem Cells nLung,melanoma,myeloma,prostate and thyroid cancers.4.How are cancer stem cells identified?Table 1 Examples of non-carbohydrate stem cell markers which are also cancer stem cell markers5.What happens after stem cells are identified?nhow cancer stem cells worknidentify drugs that will kill the stem cells without harming normal cells.Cancer Stem Cell Research ProgramnGoal 1.To investigate potential pathways critical for self renewal,spread and survival of normal and cancer stem cells.nGoal 2.To develop new therapies directed against cancer stem cells.6.Are clinical treatments available now to target cancer stem cells?nearly stagesnInitial results are positivenadditional trials in a larger number of patients will be necessary6.2 Figure 1 Oxaliplatin-incorporating micelles are effective for the eradication of cancer stem cells(CSCs).Abbreviations:CSO,chitosan oligosaccharide SA,stearic acid Development of nanomedicine for CSCsDrug-delivery systems for CSCs6.1 Strategies for stem cell-based antibody therapy of cancerFigure.Model of potential strategies for the use of stem cells in antibody therapy6.3 iPSCs:Induced pluripotent stem cells 6.4 Potential applications of human iPSCs for liver diseasesThank you for your attention