注射用丹参多酚酸盐与阿司匹林联用治疗冠心病心绞痛临床定位的四维度设计成.docx

注射用丹参多酚酸盐与阿司匹林联用治疗冠心病心绞痛临床定位的四维度设计成 摘要現代中西药联合用药中，中医药始终有着其不行或缺的作用，对疾病有着不行替代的疗效，为了证明中药的精准定位，探讨者应当采纳多维度的设计，解决不同阶段不同需求的问题。本文以上市后药品注射用丹参多酚酸盐疗效评价精准定位为例，对四维度疗效评价及机制探讨设计思路予以介绍，探究中医药在重大疾病治疗中不行或缺的治疗价值。首先，从HIS真实世界数据分析中发觉了注射用丹参多酚酸盐常与阿司匹林联合运用治疗冠心病心绞痛，然后运用系统评价对注射用丹参多酚酸盐常与阿司匹林联合运用治疗冠心病心绞痛的疗效进行了验证，进一步采纳网络药理学探究其疗效机制，发觉二者联合用药对冠心病心绞痛的治疗有着共同的信号通路，有疗效增加和相加作用。最终，在前期3个维度的探讨基础上，采纳PRCT优效性试验设计，以血栓弹力图的检测作为客观评价指标，以验证注射用丹参多酚酸盐与阿司匹林联合用药治疗冠心病心绞痛的疗效。以期本范例为中药药品上市后疗效评价精准定位供应范例，供临床科研工作者参考和借鉴。 关键词注射用丹参多酚酸盐;冠心病心绞痛;精准定位;循证评价;多维度;好用性随机比照试验;血栓弹力图;方法学 Four-dimensionalDesignofClinicalLocalizationofSalvianolateInjectionCombinedwithAspirinintheTreatmentofCoronaryHeartDiseaseAnginaPectoris CHENGFENGJingming，WANGLianxin，XIEYanming AbstractInmoderntimes，traditionalChinesemedicinehasalwaysplayedanindispensableroleinthecombineduseoftraditionalChineseandwesternmedicine，andhasirreplaceablecurativeeffectsondiseases.ToprovetheaccuratepositioningofTCM，researchersshouldadoptmulti-dimensionaldesigntosolveproblemsofdifferentneedsatdifferentstages.Inthispaper，theprecisepositioningoftheefficacyevaluationofSalvianolateInjectionofpost-marketingdrugswastakenasanexampletointroducethedesignideasofthefour-dimensionalefficacyevaluationandmechanismresearch，inordertoexploretheindispensabletherapeuticvalueofTCMinthetreatmentofmajordiseases.Firstofall，theHISdataanalysisfoundintherealworldforSalvianolateInjectionisoftenassociatedwithaspirinuseinthetreatmentofcoronaryheartdiseaseanginapectoris，andthenthesystematicevaluationwasusedforverifyingtheeffectsofSalvianolateInjectionassociatedwithaspirininthetreatmentofcoronaryheartdiseaseanginapectoris，furthertoexplorethecurativeeffectbyusingnetworkpharmacologymechanism，whichfoundcommonsignalingpathwaysforthecombinationtreatmentofcoronaryheartdiseaseanginapectorisandhasefficacyenhancingandadditiveeffect.Finally，onthebasisofthepreviousthreedimensionalstudies，PRCToptimalefficacytestdesignwasadopted，andthedetectionofthrombuselasticogramwasusedasanobjectiveevaluationindextoverifytheefficacyofSalvianolateInjectioncombinedwithaspirininthetreatmentofcoronaryheartdiseaseandanginapectoris.Itisexpectedthatthisexamplewillprovideanexamplefortheaccuratepositioningofthepost-marketingefficacyevaluationofTCMdrugsforthereferenceofclinicalresearchers. 第3页 共3页第 3 页 共 3 页第 3 页 共 3 页第 3 页 共 3 页第 3 页 共 3 页第 3 页 共 3 页第 3 页 共 3 页第 3 页 共 3 页第 3 页 共 3 页第 3 页 共 3 页第 3 页 共 3 页