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1、 论文成果： PUBLICATIONS 1. Zhang, X-k., Huang, D.P., Chiu, D.K., and Chiu, J.F. The expression of oncogenes in human developing liver and hepatomas. Biochem. Biophys. Res. Comm. 142: 932-938. 1987. 2. Zhang, X-k., Wang, Z., Lee, A., Huang, D.P., and Chiu, J.F. Differential expression of cellular oncogen

2、es during rat liver development. Cancer Lett. 41: 147-155. 1988. 3. Li, P.M., Zhong, J.L., Chen, R.Q., Zhang, X-k., Ho, K.L., Chiu, J.F., and Huang, D.P. Zhi-mu saponin inhibits alpha-fetoprotein gene expression in developing rat liver. Int. J. Biochem. 21: 15-22. 1989. 4. Graupner, G., Wills, K.N.,

3、 Tzukerman, M., Zhang, X-k., and Pfahl, M. Dual regulatory role for thyroid-hormone receptors allows control of retinoic acid receptor activity. Nature (London) 340: 653-656. 1989. 5. Zhang, X-k., Huang, D.P., Qiu, D.K., and Chiu, J.F. The expression of c-myc and c-N-ras in human cirrhotic livers, h

4、epatocellular carcinomas and liver tissue surrounding the tumors. Oncogene 5: 909-914. 1990. 6. Hoffmann, B., Lehmann, J.M., Zhang, X-k., Hermann, T., Graupner, G., and Pfahl, M. A retinoic acid receptor-specific element controls the retinoic acid receptor- promoter. Mol. Endocrinol. 4: 1727-1736. 1

5、990. 7. Tzukerman, M., Zhang, X-k., Hermann, T., Wills, K.N., Graupner, G., and Pfahl, M. The human estrogen receptor has transcriptional activator and repressor functions in the absence of ligand. New Biol. 2: 613-620. 1990. 8. Pfahl, M., Tzukerman, M., Zhang, X-k., Lehmann, J.M., Hermann, T., Will

6、s, K.N., and Graupner, G. Nuclear retinoic acid receptors: cloning, analysis, and function. Methods Enzymol. 189: 256-270. 1990. 9. Zhang, X-k., Zucker, M.I., Huang, D.P., Lin, T-S., Prusoff, W.H., and Chiu, J.F. Alteration of cellular oncogene expression in L1210 cells by a nitrosoureaalalog of thy

7、midine. Cancer Comm. 3: 119-126. 1991. 10. Zhang, X-k., Dong, J.M., and Chiu, J.F. Regulation of -fetoprotein gene expression by antagonism between AP-1 and the glucocorticoid receptor at their overlapping binding site. J. Biol. Chem. 266: 8248-8254. 1991. 11. Graupner, G., Zhang, X-k., Tzukerman, M

8、., Wills, K.N., Hermann, T., and Pfahl, M. Thyroid hormone receptors repress estrogen receptor activation of a TRE. Mol. Endocrinol. 5: 365-372. 1991. 12. Hermann, T., Zhang, X-k., Tzukerman, M., Wills, K.N., Graupner, G., and Pfahl, M. Regulatory functions of a non-ligand-binding thyroid hormone re

9、ceptor isoform. Cell Regul. 2: 565-574. 1991. 13. Pfahl, M., Zhang, X-k., Lehmann, J.M., Husmann, M., Graupner, G., and Hoffmann, B. Molecular mechanisms of retinoic acid action. In G. Morriss-Kay (ed.), Retinoids in normal development and teratogenesis. Oxford University Press, Oxford. p. 51-64. 19

10、92. 14. Zhang, X-k., Wills, K.N., Graupner, G., Tzukerman, M., Hermann, T., and Pfahl, M. Ligand-binding domain of thyroid hormone receptors modulates DNA binding and determines their bifunctional roles. New Biol. 3: 169-181. 1991. 15. Wills, K.N., Zhang, X-k., and Pfahl, M. Coordinate expression of

11、 functionally distinct thyroid hormone receptor isoforms during neonatal brain development. Mol. Endocrinol. 5: 1109-1119. 1991. 16. Tzukerman, M., Zhang, X-k., and Pfahl, M. Inhibition of estrogen receptor activity by the tumor promoter 12-O-tetradeconylphorbol-13-acetate: a molecular analysis. Mol

12、. Endocrinol. 5: 1983-1992. 1991. 17. Yang-Yen, H-F*., Zhang, X-k.*, Graupner, G., Tzukerman, M., Sakamoto, B., Karin, M, and Pfahl, M. Antagonism between retinoic acid receptors and AP-1: implications for tumor promotion and inflammation. New. Biol. 3: 1206-1219. 1991. *Equal contribution. 18. Zhan

13、g, X-k., Tran, P.B., and Pfahl, M. DNA binding and dimerization determinants for thyroid hormone receptor and its interaction with a nuclear protein. Mol. Endocrinol. 5: 1909-1920. 1991. 19. Zhang, X-k., Wills, K.N., Husmann, M., Hermann, T., and Pfahl, M. Novel pathway for thyroid hormone receptor

14、action through interaction with junand fos oncogene activities. Mol. Cell. Biol. 11: 6016-6025. 1991. 20. Zhang, X-k., Hoffmann, B., Tran, P., Graupner, G., and Pfahl, M. Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors. Nature (London) 355: 441-446. 1992.

15、21. Lehmann, J.M., Zhang, X-k., and Pfahl, M. RAR2 expression is regulated through a retinoic acid response element embedded in SP1 sites. Mol. Cell. Biol. 12: 2976-2985. 1992. 22. Hermann, T., Hoffmann, B., Zhang, X-k., Tran, P., and Pfahl, M. Heterodimeric receptor complexes determine 3,5,3-triiod

16、othyronine and retinoid signaling specificities. Mol. Endocrinol. 6: 1153-1162. 1992. 23. Zhang, X-k., Egan, J.O., Huang, D-p., Sun, Z.L., Chien, V.K., and Chiu, J.F. Hepatitis B virus DNA integration and expression of an erbB-like gene in human hepatocellular carcinoma. Biochem. Biophys. Res. Commu

17、n. 188: 344-351. 1992. 24. Tran, P., Zhang, X-k., Salbert, G., Hermann, T., Lehmann, J.M., and Pfahl, M. COUP orphan receptors are negative regulators of retinoic acid response pathways. Mol. Cell. Biol. 12: 4666-4676. 1992. 25. Zhang, X-k., Lehmann, J.M., Hoffmann, B., Dawson, M., Cameron, J., Grau

18、pner, G., Hermann, T., Tran, P., and Pfahl, M. Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid. Nature (London) 358: 587-591. 1992. 26. Hermann, T., Hoffmann, B., Piedrafita, F.J., Zhang, X-k., and Pfahl, M. V-erb A requires auxiliary proteins for dominant negative activity

19、. Oncogene. 8: 55-65. 1993. 27. Zhang, X-k. and Pfahl, M. Regulation of retinoid and thyroid hormone action through homodimeric and heterodimeric receptors. Trends Endocrinol. Metab. 4: 156-162. 1993. 28. Lehmann, J.M., Zhang, X-k., Graupner, G., Lee, M.O., Hermann, T., Hoffmann, B., and Pfahl, M. F

20、ormation of retinoid X receptor homodimers leads to repression of T3 response: hormonal cross talk by ligand-induced squelching. Mol. Cell. Biol. 13: 7698-7707. 1993. 29. Zhang, X-k. and Pfahl, M. Hetero- and homodimeric receptors in thyroid hormone and vitamin A action. Receptor. 3: 183-191. 1993.

21、30. Zhang, X-k. and Pfahl, M. Molecular mechanisms of action for vitamin-A derived hormones in receptor-mediated biological processes. Implications for Evaluating Carcinogens. (ed. T.J. Slaga). Wiley-Liss Press. 1993. 31. Zhang, X-k., Salbert, G., Lee, M-O., and Pfahl, M. Mutations that alter ligand

22、-induced switches and dimerization activities in the retinoid X receptor. Mol. Cell. Biol. 14: 4311-4323. 1994. 32. Pfahl, M., Apfel, R., Bendik, I., Fanjul, A., Graupner, G., Lee, M-O., La-Vista, N., Lu, X-P, Piedrafita, J., Ortiz-Caseda, A., Salbert, G., and Zhang, X-k. Nuclear retinoid receptors

23、and their mechanism of action. Vitamins and hormones. (ed. Gerald Litwac). Vol. 49, pp. 327-382. 1994. 33. Lee, M-O., Hobbs, P.D., Zhang, X-k., Dawson, M.I., and Pfahl, M. A synthetic retinoid antagonist inhibits the human immunodeficiency virus type 1 promoter. Proc. Nat. Acad. Sci. 91: 5632-5636.

24、1994 34. Zhang, X-k., Liu, Y., Lee, M-O., and Pfahl, M. A specific defect in the retinoic acid response associated with human lung cancer cell lines. Cancer Res. 54: 5663-5669. 1994. 35. Zhang, X-k. Molecular mechanisms of action for vitamin A-derived hormones. Prog. Clin. Biol. Res. 387: 59-71. 199

25、4. 36. Lee, M-O., Liu, Y., and Zhang, X-k.A retinoic acid response element that overlaps an estrogen response element mediates multihormonal sensibility in transcriptional activation of the lactoferrin gene. Mol. Cell. Biol. 15: 4194-4207. 1995. 37. Alam, M., Zhestkov, V., Sani, B.P., Venepally, P.,

26、 Levin, A.A., Kazmer, S., Li, E., Norris, A.W., Zhang, X-k., Lee, M.-O., Hill, D.L., Lin, T.-H., Brouillette, and Muccio, D.D. Conformationally defined 6-s-trans retinoic acid analogs. 2: Selective agonists for nuclear receptor binding and transactivational activity. J. Med. Chem. 38: 2302-2310. 199

27、5. 38. Dawson, M.I., Chao, W-R., Pine, P., Jong, L., Hobbs, P.D., Rudd, C., Quick, T.C., Niles, R.M., Zhang, X-k., Lombardo, A., Ely, K.R., Shroot, B., and Fontana, J.A. Correlation of retinoid binding affinity to RAR with retinoid inhibition of growth of estrogen receptor-positive MCF-7 mammary car

28、cinoma cells. Cancer Res. 55: 4446-4451. 1995. 39. Zhang, X-k., Liu, Y., and Lee, M-O. Retinoid receptors in human lung cancer and breast cancer. Mutat. Res. 350: 267-277. 1996. 40. Liu, Y., Lee, M-O., Wang, H-G., Li, Y., Hashimoto, Y., Klaus, M., Reed, J., and Zhang, X-k. RAR mediates the growth-in

29、hibitory effect of retinoic acid by promoting apoptosis in human breast cancer cells. Mol. Cell. Biol. 16: 1138-1149. 1996. 41. Sani, P., Zhang, X.-k., Hill, D.L., and Shealy, Y.F. Retinyl methyl ether: binding to transport proteins and effect on transcriptional regulation. Biochem. Biophys. Res. Co

30、mm. 223: 293-298. 1996. 42. Sani, B.P., Venepally, P., Zhang, X-k., Hill, D.L., and Shealy, F. Biochemical characteristics and differentiating activity of 4-oxo analogs of retinoic acid. Anticancer Res. 16: 1177-1181. 1996. 43. Wu, Q., Li, Y., Liu, R., Agadir, A., Lee, M-O., Liu, Y., and Zhang, X-k.

31、 Modulation of retinoic acid sensitivity in lung cancer cells through dynamic balance of orphan receptors nur77 and COUP-TF and their heterodimerization. EMBO J. 16: 1656-1669. 1997. 44. Agadir, A., Shealy, Y. F., Hills, D.L., and Zhang, X-k.Retinyl methyl ether down-regulates activator protein 1 tr

32、anscriptional activation in breast cancer cells. Cancer Res. 57: 3444-3450. 1997. 45. Wu, Q., Dawson, M.I., Zheng, Y., Hobbs, P.D., Agadir, A., Jong, L., Li, Y., Liu, R., Lin, B., and Zhang, X-k. Inhibition of trans-RA-resistant human breast cancer cell growth by retinoid X-receptor-selective retino

33、ids. Mol. Cell. Biol. 17: 6598-6608. 1997. 46. Chao, W-r, Hobbs, P.D., Jong, L., Zhang, X-k., Zheng, Y., Wu, Q., Shroot, B., and Dawson, M.I. Effects of receptor class- and subtype-selective retinoids and an apoptosis-inducing retinoid on the adherent growth of the NIH:OVCAR-3 ovarian cancer cell li

34、ne in culture. Cancer Lett. 115: 1-7. 1997. 47. Giannini, G., Dawson, M.I., Zhang, X-k., and Thiele, C.J. Activation of three distinct RXR/RAR heterodimers induces growth arrest and differentiation of neuroblastoma cells. J. Biol. Chem. 272: 26693-26701. 1997. 48. Li, Y., Dawson, M.I., Agadir, A., L

35、ee, M-O., Jong, L., Hobbs, P.D., and Zhang, X-k. Regulation of RAR beta expression by RAR- and RXR-selective retinoids in human lung cancer cell lines: effect on growth inhibition and apoptosis induction. Int. J. Cancer 75: 88-95. 1998. 49. Muccio, D.D., Brouillette, W.J., Breitman, T.R., Taimi, M.,

36、 Emanuel, P.D., Zhang, X-k., Chen, G-q., Sani, B.P., Venepally, P., Lakshimi, R., Alam, M., Simpson-Herren, L., and Hill, D.L. Conformationally defined retinoic acid analogues. 4, potential new agents for acute promyelocytic and juvenile myelomonocyticleukemias. J. Med. Chem. 41: 1679-1687. 1998. 50

37、. Liu, R., Takayama, S., Zheng, Y., Froesch, B., Chen, G-q., Zhang, X., Reed, J.C., and Zhang, X-k. Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells. J. Biol. Chem. 273: 16985-16992. 1998. 51. Li, Y., Lin, B., Agadir, A., Liu, R.,

38、 Dawson, M.I., Reed, J.C., Fontana, J.A., Bost, F., Hobbs, P.D., Zheng, Y., Chen, G.Q., Shroot, B., Mercola, D., and Zhang, X-k. Molecular determinants of AHPN (CD437)-induced growth arrest and apoptosis in human lung cancer cell lines. Mol. Cell. Biol. 18: 4719-4731. 1998. 52. Dawson, M.I., Chao, W

39、.R., Hobbs, P.D., and Zhang, X-k. Effects of trans-retinoic acid, 9-cis-retinoic acid, 1alpha, 25-(dihydroxy) vitamin D3 and a novel apoptosis-inducing retinoid on breast cancer and endothelial cell growth. Cancer Lett. 133: 1-8. 1998. 53. Agadir, A., Lazzaro, G., Zheng, Y., Zhang, X-k., and Mehta,

40、R.G. Resistance of HBL100 human breast epithelial cells to vitamin D action. Carcinogenesis 20: 577-582. 1999. 54. Li, Y., Hashimoto, Y., Agadir, A., Kagechika, H., and Zhang, X-k. Identification of a novel class of retinoic acid receptor -selective retinoid antagonists and their inhibitory effects

41、on AP-1 activity and retinoic acid-induced apoptosis in human breast cancer cells. J. Biol. Chem. 274: 15360-15366. 1999. 55. Agadir, A., Chen, G-q., Bost, F., Li, Y., Mercola, D., and Zhang, X-k. Differential effect of retinoic acid on growth regulation by phorbol ester in human cancer cell lines.

42、J. Biol. Chem. 274: 29779-29785. 1999. 56. Lin, B., Chen, G-q., Xiao, D., Kolluri, S.K., Cao, X., Su, H., and Zhang, X-k.Orphan receptor COUP-TF is required for induction of retinoic acid receptor , growth inhibition and apoptosis by retinoic acid in cancer cells. Mol. Cell. Biol. 20: 957-970. 2000.

43、 57. Dawson, M.I., Hobbs, P.D., Jong, L., Xiao, D., Chao, W-r., Pan, C., and Zhang, X-k.sp2-bridgeddiarylretinoids: effect of bridge-region substitution on retinoid X receptor (RXR) selectivity. Bioorg. Med. Chem. Lett. 10: 1307-1310. 2000. 58. Dawson, M.I., Jong, L., Hobbs, P.D., Xiao, D., Feng, K.

44、C., Chao, W-r., Pan, C., Fontana, J.A., and Zhang, X-k. 4-3-(5,6,7,8-Tetrahydro-5,5,8,8,-tetramethyl-2-naphthalenyl)-phenylbenzoic acid and hetercyclic-bridged analogs are novel retinoic acid receptor subtype and retinoid X receptor alpha agonists. Bioorg. Med. ChemLett. 10: 1311-1313. 2000. 59. Lin

45、, F., Xiao, D., Kolluri, S.K., and Zhang, X-k.Unique anti-activator protein-1 activity of retinoic acid receptor-. Cancer Res. 60: 3271-3280. 2000. 60. Dawson, M.I., Zhang, X-k., Hobbs, P.D., and Jong, L. Synthetic retinoids and their usefulness in biology and medicine. Vitamin A and retinoids: an u

46、pdate of biological aspects and clinical applications. M.A. Livrea (ed.), BirkhuserVerlag Basel/Switzerland.pp161-196. 2000. 61. Li, H., Kolluri, S., Gu, J., Dawson, M.I., Cao, X., Hobbs, P., Lin, B., Chen, G-q., Lu, J-s., Lin, F., Xie, Z., Fontana, J. A., Reed, J. C., and Zhang, X-k. Cytochrome c r

47、elease and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3. Science. 289: 1159-1164. 2000. 62. Dawson, M.I., Park, J., Chen, G-q., Chao, W-r., Dousman, L., Waleh, N., Hobbs, P., Jong, L., Toll, L., Zhang, X-k., Gu, J., Agadir, A., Merchant, J., Bai, L., Verma, A., Thacher

48、, S., Chandraratna, R., Shroot, B., and Hill, D. Retinoic acid (RA) receptor transcriptional activation correlates with inhibition of 12-O-Tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity by retonoids. A potential role for Trans-RA-induced ZBP-89 in ODC inhibition. Int. J. Ca

49、ncer. 91: 8-21. 2001. 63. Dawson, M.I., Hobbs, P., Peterson, V., Leid, M., Lange, C., Feng, K., Chen, G., Gu, J., Li, H., Kolluri, S., Zhang, X-k., Zhang, Y., and Fontana, J. Apoptosis induction in cancer cells by a novel analogue of 6-3-(1-adamantyl)-4-hydroxyphenyl-2-naphthalenecarboxylic acid lacking retinoid receptor transcriptional activation activity. Cancer Research. 61: 4723-4730. 2001. 64. Stelle-Perkins, G., Fang, W., Yang