最新大学本科有机化学41氨基酸教学课件.ppt

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1、CHOHOHCH2OHCOOHH2NHRL 氨氨基基酸酸L 甘甘油油醛醛NH2COOHRH2NCOOHRHHRCHCOOHNH2CH3OHHClLiAlH4RCHCOOCH3NH2RCHCH2OHNH2OOOHOH+NH2COOHR+H2O+CO2OOOON+RCHO蓝蓝紫紫色色，罗罗曼曼紫紫H2NRHNOCOOHRH2NHNOOCH3NHOH3CCH3OH甘甘丙丙缬缬（Gly-Ala-Val)H2NROOHClCPhCH2OOEt3NNHROOHCPhCH2OOH2NROO CH3DCC, HOBtNHRHNOOCH3ORCbzH2PdH2NRHNOOCH3OR去去氨氨基基端端保保护护保保护

2、护氨氨基基端端+PhCH3+CO2H2NROOHClCPhCH2OOEt3NNHROOHCPhCH2OOH2NROO CH3DCC, HOBtNHRHNOOCH3ORCbzH2PdH2NRHNOOCH3OR去去氨氨基基端端保保护护保保护护氨氨基基端端+PhCH3+CO2H2NROOHClCPhCH2OOEt3NNHROOHCPhCH2OOH2NROO CH3DCC, HOBtNHRHNOOCH3ORCbzH2PdH2NRHNOOCH3OR去去氨氨基基端端保保护护保保护护氨氨基基端端+PhCH3+CO2H2NROOHClCPhCH2OOEt3NNHROOHCPhCH2OOH2NROO CH3DC

3、C, HOBtNHRHNOOCH3ORCbzH2PdH2NRHNOOCH3OR去去氨氨基基端端保保护护保保护护氨氨基基端端+PhCH3+CO2H2NROOHClCPhCH2OOEt3NNHROOHCPhCH2OOH2NROO CH3DCC, HOBtNHRHNOOCH3ORCbzH2PdH2NRHNOOCH3OR去去氨氨基基端端保保护护保保护护氨氨基基端端+PhCH3+CO2H2NROOHEt3NNHROOHH2NROO CH3DCC, HOBtNHRHNOOCH3ORBocHClH3NRHNOOHOR去去氨氨基基端端保保护护保保护护氨氨基基端端OOC(CH3)3(H3C)3COOO(H3C)

4、3COO+H2CCH3CH3+CO2(Boc2O)(Boc)The Nobel Prize in Chemistry 1984for his development of methodology for chemical synthesis on a solid matrixRobert Bruce MerrifieldUSARockefeller University New York, NY, USAb. 1921d. 2006CH3OCH2ClSnCl4CH2OH2NCHRCOOHH2OCHRNH2OCH2Cl碱碱基基核核糖糖 或或脱脱氧氧核核糖糖核核苷苷磷磷酸酸核核苷苷酸酸核核酸酸聚聚

5、合合碱碱基基核核糖糖 或或脱脱氧氧核核糖糖核核苷苷磷磷酸酸核核苷苷酸酸核核酸酸聚聚合合CHOHOHHOHCH2OHHOHD- -( (- -) )- -核核糖糖OHOOHOHHHHHHO12345OHOHOHHHHHHO12345 - -D- -( (- -) )- -呋呋喃喃核核糖糖 - -D- -呋呋喃喃脱脱氧氧核核糖糖12345OOHOHHHHHHO12345NNNH2O一一种种核核苷苷OHOHHHHHHO12345一一种种脱脱氧氧核核苷苷NNNNNH2NNNHNNH2NHNNONH2NH腺腺嘌嘌呤呤鸟鸟嘌嘌呤呤NHNNH2ONHNHOOH3CNHNHOO胞胞嘧嘧啶啶胸胸腺腺嘧嘧啶啶尿尿嘧嘧啶啶OHOHHHHHO12345NNNH2OOOHOHHHHHO12345NNNNNH25- -胞胞嘧嘧啶啶脱脱氧氧核核苷苷酸酸3- -腺腺嘌嘌呤呤核核苷苷酸酸POOHOHPOOHOHOHHHHHO135NNNH2OPOOHOHHHHHO15POOOHNNNNNH2OHHHHHO135POOOHONHNNONH2NOHHHHHO135POOHOPOOOHONNHOOH3C