T组合使用.ppt
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1、2哥伦比亚哥伦比亚 CPAP(Bubble CPAP)3Bubble CPAP的作用的作用 Bubble CPAP 显著地减少了低出生体重婴儿发生慢性肺疾病的事故。 Bubble CPAP通过改善气体交换,可以降低潮气量和呼吸频率,降低呼吸功,减少呼吸疲劳和对气管插管的需要。Ref: Mary Ellen Avery, MD, William Tooley, MD, et.al. (Jan 1987). Is Chronic Lung Disease in Low Birth Weight Infants Preventable? A Survey of Eight Centers. Pedi
2、atrics 79(1): 26-30 Kyong-Soon Lee, Michael Dunn, et. al. (1998) A comparison of Underwater Bubble Continuous Positive Airway Pressure with Ventilator-Derived Continuous Positive Airway Pressure in Premature Neonates Ready for Extubation. Biol Neonate 73: 69-754Bubble CPAP的作用的作用Ref: J Paediatr Child
3、 Health. 2001 Apr;37(2):161-7. 5Bubble CPAP的作用的作用 Early bubble CPAP reduced delivery room intubations, days on mechanical ventilation, postnatal steroid use and was associated with increased postnatal weight gain with no increased complications.Ref: Narendran V, Donovan EF, Hoath SB, et. al. Early b
4、ubble CPAP and outcomes in ELBW preterm infants. J Perinatol. 2003 Apr-May;23(3):195-9.6Bubble CPAP的作用的作用 CONCLUSIONS: Compared to constant pressure technique, bubble continuous positive airway pressure promotes enhanced airway patency during treatment of acute postnatal respiratory disease in prete
5、rm lambs and may offer protection against lung injury. Ref: Pillow JJ, Hillman N,Moss TJ, et. al. Am J Respir Crit Care Med. 2007 Apr 12 7Bubble CPAP的作用的作用 CONCLUSIONS: Bubble CPAP is as effective as IFD CPAP in the post-extubation management of infants with RDS; however, in infants ventilated for o
6、r = 14 days, bubble CPAP is associated with a significantly higher rate of successful extubation. Bubble CPAP also is associated with a significantly reduced duration of CPAP support. Ref: Gupta S, Sinha SK, Tin W, Donn SM. J Pediatr. 2009 May;154(5):633-4. 8压力波形压力波形 ( (体内体内) ) 振荡压力波形的确从气道传递到肺,而且低顺应
7、性的压力波形所含有的高频成分和能量可能对婴儿的气体氧合有所帮助。Ref:Travadi JN and Pillow JJ. Effect of Compliance and Flow on Pressure Waveform in the Lung During Bubble CPAP. King Edward Memorial andPrincess Margaret Hosps, and Institute for Child Health Research, Perth, An in vitro Study. Perinatal Society of Australia & New Ze
8、aland 5th Annual Congress in Conjunction with the Australasian Society 9压力波形压力波形 (体内)(体内)婴儿体重是婴儿体重是15001500克,克,CPAP CPAP 压力为压力为6 6厘米水柱厘米水柱10压力波形压力波形 (体内)(体内)CPAP的压力为的压力为5 5cmcm水柱水柱11Bubble CPAP的好处的好处结论是 bubble CPAP 增加功能残气量,改善氧合、提高肺的顺应性。 通过改善气体弥散降低新生儿的呼吸功。 减少机械通气的不良后果。 降低慢性肺疾病的发病率。12Bubble CPAP的适应症的适
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