卵巢肿瘤英文ppt课件.ppt

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1、“雪亮工程是以区（县）、乡（镇）、村（社区）三级综治中心为指挥平台、以综治信息化为支撑、以网格化管理为基础、以公共安全视频监控联网应用为重点的“群众性治安防控工程”。OVARIAN CANCER“雪亮工程是以区（县）、乡（镇）、村（社区）三级综治中心为指挥平台、以综治信息化为支撑、以网格化管理为基础、以公共安全视频监控联网应用为重点的“群众性治安防控工程”。INTRODUCTION“雪亮工程是以区（县）、乡（镇）、村（社区）三级综治中心为指挥平台、以综治信息化为支撑、以网格化管理为基础、以公共安全视频监控联网应用为重点的“群众性治安防控工程”。I.Histologic Classificati

2、on i.coelomic epithelium originating tumor accounts for 50-70% of primal ovarian tumor , 85-90% of ovarian malignace.developed from germinal epithelium primal coelomic epithelium various muller,s epithelium tubal epithelium,cervical mucosa epithelium,endometrium the coelomic epithelial tumors includ

3、e (i).serous tumor (ii).mucinous tumor (iii).endometrioid tumor (iv).clear cell tumor“雪亮工程是以区（县）、乡（镇）、村（社区）三级综治中心为指挥平台、以综治信息化为支撑、以网格化管理为基础、以公共安全视频监控联网应用为重点的“群众性治安防控工程”。 (v).Brenner tumor/transitional cell tumor (vi).mixed epithelial tumor (vii).undifferentiated carcinoma ii.germ cell tumor accounts

4、for 20-40% of ovarian tumor.germ cells originate from endogerm tissues.in the course of its origination, transformation and development the cellular heterogeneity may occur and form various tumors germ cell tumors include (i).dysgerminoma (ii).endodermal sinus tumor“雪亮工程是以区（县）、乡（镇）、村（社区）三级综治中心为指挥平台、

5、以综治信息化为支撑、以网格化管理为基础、以公共安全视频监控联网应用为重点的“群众性治安防控工程”。 (iii).embryonic carcinoma (iv).polyembryonic tumor (v).choriocarcinoma (vi).teratoma i).immature type ii).mature type (a).solid teratoma (b).cystic teratoma a).dermoid cyst b).malignant change of dermoid cyst (c).monodermal and highly specialized tum

6、ors a).struma ovarii b).carcinoid (vii).mixed type“雪亮工程是以区（县）、乡（镇）、村（社区）三级综治中心为指挥平台、以综治信息化为支撑、以网格化管理为基础、以公共安全视频监控联网应用为重点的“群众性治安防控工程”。 iii.ovarian gonadal sex cord stromal tumor accounts for 5% of ovarian tumor.sex cord stroma originates from mesenchymal tissues of primal coelom female and male diffe

7、rentiation epithelium differentiationgranulosa, Sertolic cell tumor functional tumor stromal differentiation theca cell, Leydig cell tumor sex cord stromal cells tumor includes (i).granulosa cell-stromal tumor i).granulosa cell tumor ii).theca cell tumor,fibroma“雪亮工程是以区（县）、乡（镇）、村（社区）三级综治中心为指挥平台、以综治信

8、息化为支撑、以网格化管理为基础、以公共安全视频监控联网应用为重点的“群众性治安防控工程”。 (ii).Sertolic-Leydig cell tumor i).androblastoma (iii).gynandroblastoma iv.metastasized tumor“雪亮工程是以区（县）、乡（镇）、村（社区）三级综治中心为指挥平台、以综治信息化为支撑、以网格化管理为基础、以公共安全视频监控联网应用为重点的“群众性治安防控工程”。II.High risk factors of ovarian tumors i.hereditary and family factors about 2

9、0-25% malignant ovarian tumors have family history ii.environmental factors the mobidity of ovarian cancer is high in industry developed countrys,this may be because of high cholesterol diet in these countrys iii.endocrinic factors mobidity in less pregnant or infertile women is high(why), functiona

10、l cancers may easily complicated with mammary andendometrial cancer“雪亮工程是以区（县）、乡（镇）、村（社区）三级综治中心为指挥平台、以综治信息化为支撑、以网格化管理为基础、以公共安全视频监控联网应用为重点的“群众性治安防控工程”。III.pathology i.epithelial ovarian tumors age:30-60 ;classification:benigh,borderline,malignant borderline tumor means: (i).serous cystadenoma mobidit

11、y :accounts for 25%benigh tumors macroexamination :unilateral,globular,different size,smooth surface,cystic,thin wall and filled by clear light-yellow fluid section : simple type,monocystic,smooth wall;papillary type, multicystic,intracystic papilla microscopic exanination : tumor wall is composed o

12、f fibro- connective tissues and lined by a single layer of cuboid or columnar epithelium “雪亮工程是以区（县）、乡（镇）、村（社区）三级综治中心为指挥平台、以综治信息化为支撑、以网格化管理为基础、以公共安全视频监控联网应用为重点的“群众性治安防控工程”。 borderline serous cystadenoma macroexamination : moderate size bilateral,more extracystic papilla microscopic examination :thin

13、 papillary branch,epithelium3 layers,slight cellular atypia,nuclear mitosis3 layers,obvious cellular atypia,stromal invasion 5 year survival rate:40-50%,prognosis is better than serous cystadenocarcinoma “雪亮工程是以区（县）、乡（镇）、村（社区）三级综治中心为指挥平台、以综治信息化为支撑、以网格化管理为基础、以公共安全视频监控联网应用为重点的“群众性治安防控工程”。 (iii).endome

14、trioid tumor morbidity : less encountered,benign macroexamination : more unilateral,smooth surface microscopic examination : surface is a single layer of columnar epithelium which very like endometrial gland epithelium, cavity is lined by pavement epithelium borderline:rare endometrioid carcinoma mo

15、rbidity :10-24% of primary malignant tumor macroexamination:more unilateral,moderate size section:cystic or solid,papilla,bloody fluid microscopic examination:very similar to endometrial cancer, more adenocarcinoma or adenoacanthoma,often complicated with endometrial carcinoma 5 year survival rate :

16、40-50% “雪亮工程是以区（县）、乡（镇）、村（社区）三级综治中心为指挥平台、以综治信息化为支撑、以网格化管理为基础、以公共安全视频监控联网应用为重点的“群众性治安防控工程”。 ii.ovarian germ cell tumors a group of ovarian tumors originated from primal germ cells, its morbidity is secondary to the epithelial tumors,most occurs in childhood and adolescence,morbidity before adolescenc

17、e accounts for 60-90%,while after menopause it only accounts4% (i).teratoma mature teratoma :also called dermoid cyst morbidity :the most common benign ovarian tumor,10-20% of ovarian tumors,85-97%of germ cell tumors,over 95% of teratoma age :occurs at any age,mostly between 20-40 macroexamination :

18、more unilateral,moderate size,round or elliptic,smooth and thin walll,“雪亮工程是以区（县）、乡（镇）、村（社区）三级综治中心为指挥平台、以综治信息化为支撑、以网格化管理为基础、以公共安全视频监控联网应用为重点的“群众性治安防控工程”。 section :more nuicystic,filled by lipid and hair,occasionally tooth and bone can be seen,scolex on the wall components :endoderm,ectoderm and meso

19、derm highly specialized teratoma : monoderm,such as struma ovarii malignant change rate :2-4%,more in postmenopause,metasta- sized by spreading and peritoneal implantation prognosis :bad,5 year survival rate 15-31% immature teratoma : malignant tumor components :2-3germ layers,immature embryonic tis

20、sue age:adolescence macroexamination : more solid malignance :dependent upon the ratio and differentiation of immature tissue and the quantity of nervous epithelium recurrent and metastatic rate : high,5year survival rate20%“雪亮工程是以区（县）、乡（镇）、村（社区）三级综治中心为指挥平台、以综治信息化为支撑、以网格化管理为基础、以公共安全视频监控联网应用为重点的“群众性治

21、安防控工程”。 (ii).dysgerminoma :mid malignant tumor morbidity :5%of malignant ovarian tumors most in adolescence and reproductive period macroexamination :solid, more unilateral,round or elliptic, moderate size,touching like eraser,smooth surface or lobular section:light-brown color microscopic examinati

22、on :round or polygonal cells,lymphocyte invasion in stroma prognosis :very sensitive to radiotherapy,5year survival rate90%“雪亮工程是以区（县）、乡（镇）、村（社区）三级综治中心为指挥平台、以综治信息化为支撑、以网格化管理为基础、以公共安全视频监控联网应用为重点的“群众性治安防控工程”。 (iii).endodermal sinus tumor :also called yolk sac tumo morbidity : rarely encountered age :

23、mostly occurred in children and young women macroexamination :unilateral,relatively large,round or elliptic section:partially cystic,brittle tissue,bleeding and necrosis area, gray-red or gray-yellow color microscopic examination:endodermal sinus structure,flat or cuboid or columnar tumor cells whic

24、h produce AFP,AFP is an important diagnostic and therapeutic marker prognosis:average survival time is 1 year“雪亮工程是以区（县）、乡（镇）、村（社区）三级综治中心为指挥平台、以综治信息化为支撑、以网格化管理为基础、以公共安全视频监控联网应用为重点的“群众性治安防控工程”。 iii.ovarian gonadal sex cord stromal tumor accounts for 5-8%of malignant ovarian tumor (i).granulosa-stroma

25、l cell tumor i).granulosa cell tumor:low malignance morbidity:3-6%of ovarian tumor,80%of sex cord stromal tumor age:at any age,mostly between 45-55 feminization effect:secret estrogen macroexamination:unilateral,different size ,round or elliptic, lobular, smooth surface ,solid or partially cystic se

26、ction:brittle and soft tissue,bleeding and necrosis microscopic examination :Call-Exner body prognosis :better,5year survival rate over 80%“雪亮工程是以区（县）、乡（镇）、村（社区）三级综治中心为指挥平台、以综治信息化为支撑、以网格化管理为基础、以公共安全视频监控联网应用为重点的“群众性治安防控工程”。 ii).theca cell tumor :benign tumor feminization effect:secret estrogen,often

27、coexist with granulosa cell tumor macroexamination : unilateral different size ,round or elliptic, thin smooth fibrocapsule section:solid ,gray white microscopic examination :short spindal cells,lipid in cytoplasm prognosis : malignant tumor is rare ,prognosis is better than other ovarian cancer iii

28、).fibroma :common benign tumor morbidity :2-5%of ovarian tumor age : mostly in mid-aged women “雪亮工程是以区（县）、乡（镇）、村（社区）三级综治中心为指挥平台、以综治信息化为支撑、以网格化管理为基础、以公共安全视频监控联网应用为重点的“群众性治安防控工程”。 macroexamination :unilateral, moderate size,smooth surface or nodular section:gray white,solid and hard microscopic examin

29、ation:composed of spindle cells Meigs syndrome :accompanied with hydrothorax and ascites“雪亮工程是以区（县）、乡（镇）、村（社区）三级综治中心为指挥平台、以综治信息化为支撑、以网格化管理为基础、以公共安全视频监控联网应用为重点的“群众性治安防控工程”。 (ii).Sertoli Leydig cell tumor:also called androblastoma morbidity : rare age : below40 macroexamination : unilateral,small,soli

30、d smooth surface section :gray white accompanied by cystic degeneration, bloody or serous or mucinous cystic fluid virilism effect :secret androgen prognosis :10-30% is malignant ,5year survival rate 70-90%“雪亮工程是以区（县）、乡（镇）、村（社区）三级综治中心为指挥平台、以综治信息化为支撑、以网格化管理为基础、以公共安全视频监控联网应用为重点的“群众性治安防控工程”。iv.ovarian

31、metastatic tumor:all of the cancers in the human body can metastasize to the ovary,the common primary origination is at breast,intestine,stomach,reproductive tract, urinary tract and other organs morbidity:5-10%of ovarian tumor Krukenberg tumor :a special metastatic adenocarcinoma,its primary origin

32、ation is in the gastrointestinal tract macroexamination:bilateral,renal shape, no adhesion,often accompanied by ascites section:solid microscopic examination:signet-ring cell which produce mucus prognosis:very bad“雪亮工程是以区（县）、乡（镇）、村（社区）三级综治中心为指挥平台、以综治信息化为支撑、以网格化管理为基础、以公共安全视频监控联网应用为重点的“群众性治安防控工程”。 IV.

33、Metastatic Path i.metastatic character:there is subclinical metastasis on omentum,peritoneum,retroperitoneal LN and diaphragm although the tumor is localized from its apparence ii.metastatic path: (i).directly spreading:this is the chief metastatic path.the tumor cells may directly invade the capsul

34、e,involve the neighbour organs and extensively implant on the peritoneum and omentum (ii).lymphetic vessels metastasis:this is an important metastatic way which includes i).spread along the ovarian blood vessels and is metastasized to para-aortic LN through ovarian lymphetic vessels“雪亮工程是以区（县）、乡（镇）、

35、村（社区）三级综治中心为指挥平台、以综治信息化为支撑、以网格化管理为基础、以公共安全视频监控联网应用为重点的“群众性治安防控工程”。 ii).from ovarian hilus lymphetic vessels to internal and external iliac LN,and then from the common iliac LN to para-aortic LN iii).along the round ligament enters the external iliac and inguinal LN.diaphragm is the place to which th

36、e cancer is easily metastasized,especially the right diaphragm is the most easily invaded because of its dense lymphetic plexus (iii).blood metastasis is very rare.but at very late stage it may metastasize to the liver and lung“雪亮工程是以区（县）、乡（镇）、村（社区）三级综治中心为指挥平台、以综治信息化为支撑、以网格化管理为基础、以公共安全视频监控联网应用为重点的“群

37、众性治安防控工程”。 V.Histologic grades the WHO standards of histologic grading is chiefly according to the histologic structure and cellular differentiation. Grade I:means the cell is well differentiated Grade II:means moderate differenation Grade III:means undifferenation the effects of histologic grade on

38、 the prognosis is more important than that of the histologic types “雪亮工程是以区（县）、乡（镇）、村（社区）三级综治中心为指挥平台、以综治信息化为支撑、以网格化管理为基础、以公共安全视频监控联网应用为重点的“群众性治安防控工程”。 VI.Clinical stage:the FIGO(1986) clinical stage is adopted stage I tumor is localized in the ovary Ia tumor is localized in one ovary,the capsule is

39、integrated, no tumor on ovary surface,no ascites Ib tumors are localized in bilateral ovarys,integrated capsule no tumor on surface,no ascites Ic based on Ia or Ib,there is tumor on the surface(unilateral or bilateral);or capsule is ruptured;or there is malignant cells in ascites ;or the abdominal c

40、avity irrigating fluid is positive“雪亮工程是以区（县）、乡（镇）、村（社区）三级综治中心为指挥平台、以综治信息化为支撑、以网格化管理为基础、以公共安全视频监控联网应用为重点的“群众性治安防控工程”。 Stage II unilateral or bilateral ovarian tumor with pelvic metastasis IIa spread to uterus and (or)fallopian tube IIb spread to other tissues in pelvis IIc based on the IIa or IIb, t

41、here is implantation on unilateral or bilateral ovarian surface;or the capsule is ruptured;or the ascites contains malignant cells;or the abdominal cavity irrigating fluid is positive“雪亮工程是以区（县）、乡（镇）、村（社区）三级综治中心为指挥平台、以综治信息化为支撑、以网格化管理为基础、以公共安全视频监控联网应用为重点的“群众性治安防控工程”。 Stage III unilateral or bilateral

42、 ovarian tumor.there is extrapelvic peritoneal implantation and (or) the retroperitoneal or inguinal LN is positive,liver surface metastasis is stage III IIIa macroexamination shows that the tumor is loca- ted in the true pelvis,LN is negative but there is microscopic peritoneal implantation IIIb un

43、ilateral or bilateral ovarian tumor,there is peritoneal surface implantation and its diameter is2cm and (or) retroperitoneal or inguinal LN is positive stageIV unilateral or bilateral ovarian tumor with telemetastasis, hydrothorax contains cancer cells,and there is liver parenchyma metastasis“雪亮工程是以

44、区（县）、乡（镇）、村（社区）三级综治中心为指挥平台、以综治信息化为支撑、以网格化管理为基础、以公共安全视频监控联网应用为重点的“群众性治安防控工程”。VII.Clinical Manifestation i.benign ovarian tumor (i).at early stage (ii).when tumor is moderate size (iii).when tumor is large enough to occupy the full pelvis or abdominal cavity ii.malignant ovarian tumor (i).at early sta

45、ge (ii).once there are symptoms (iii).the severity of the symptoms depends ouon i).the tumor size,location and whether there is neighbour tissues or organs invasion ii).the histologic type of the tumor iii).whether there is complication“雪亮工程是以区（县）、乡（镇）、村（社区）三级综治中心为指挥平台、以综治信息化为支撑、以网格化管理为基础、以公共安全视频监控联

46、网应用为重点的“群众性治安防控工程”。 (iv).at late stage i).symptoms ii).body signsVIII.Diagnosis i.cytologic examination ii.B-Ultrasound iii.radiodiagnosis: (i).abdominal plain film (ii).intravenous pyelography,barium meal,barium double contrast radiography or mammary soft tissue X-ray (iii).CT “雪亮工程是以区（县）、乡（镇）、村（社区

47、）三级综治中心为指挥平台、以综治信息化为支撑、以网格化管理为基础、以公共安全视频监控联网应用为重点的“群众性治安防控工程”。 (iv).laparoscopy (v).tumor marker i).CA-125 ii).AFP iii).HCG iv).sexual hormone“雪亮工程是以区（县）、乡（镇）、村（社区）三级综治中心为指挥平台、以综治信息化为支撑、以网格化管理为基础、以公共安全视频监控联网应用为重点的“群众性治安防控工程”。IX.Differential Diagnosis * *i.differential diagnosis between the benign an

48、d malignant ovarian tumorDifferential contents benign tumor malignant tumorHistory long clinical course short clinical course and and gradually enlarge rapidly enlargeBody sign often unilateral,movable, often bilateral,fixed solid cystic,smooth surface or semisolid,rough surface, no ascites bloody a

49、scites with cancer cellsGeneral condition better cachexia is gradually developedB-Ultrasound dark fluid echo area,there echo group or points exist may be intracystic diaph- in the dark fluid area tumor ragm,tumor outline is outline is not clear clear“雪亮工程是以区（县）、乡（镇）、村（社区）三级综治中心为指挥平台、以综治信息化为支撑、以网格化管理

50、为基础、以公共安全视频监控联网应用为重点的“群众性治安防控工程”。 ii.differential diagnosis of benign ovarian tumor i.ovarian tumor like condition:may disappear within 2 month ii.tubo-ovarian cyst iii.uterine myoma iv.pregnant uterus v.large quantity ascites iii. differential diagnosis of malignant ovarian tumor i.endometriosis:sy