生物化学5-10章练习题英文版.doc

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1、 Exercises of Chapter 5-10 A1.Which can transport acyl-CoA into the Mitochondria? ( )A .apolipoprotein B. lipoprotein C. albumin D. citrate E. carnitine 2. In which following conditions are ketone bodies synthesis greatly accelerated? ( )A .glycolysis is enhanced B. fat mobilization is enhanced C. f

2、atty acid synthesis is enhanced D. malonyl CoA is reduced E. aerobic oxidation of glucose is enhanced3. How many moles of ATP are yielded when 1 mol glycerol is oxidized to CO2 and H2O ? ( )A .19 B. 16.5/18.5 C. 20/22 D.23 E. 174. which is the key enzyme in the regulation of FA synthesis? ( )A .fatt

3、y acid synthase B. acetyl-CoA carboxylase C. keto-acyl-ACP synthase D.enoyl-ACP reductase E. thioesterase5. NADPH in FA synthesis comes from ( ): A .aerobic oxidation of glucose B. glycolytic pathway C. gluconeogenesis D.pentose phosphate pathway E. glucuronate pathway6. which is not concerned with

4、the cholesterol biosynthesis?A .acetyl-CoA B. HMGCoA C. NADPH +H+ D.seualene E. glycerol7. the active form of choline in phospholipid biosynthesis is:A .ADP-choline B. UDP-choline C. CDP-choline D. GDP-choline E. CMP-choline8. which is not concerned with the glycerophospholipid biosynthesis? A .seri

5、ne B. GTP C. ATP D. CTP E. choline9.which is specific function of apoA?A .activates LPL B. inhibits HL C. activates LCAT D. inhibits LCAT E. activates ACAT 10.which is not required in -Oxidation of Fatty AcidsA .CoASH B. NADP+ C. carnitine D. FAD E. NAD+ 11. which is the primary carrier of cholester

6、ol in the blood of humans?A .CM B. HDL C.VLDL D. LDL E. IDL12. How many moles of ATP are yielded when 1 mol stearic acid (18 C) is oxidized to CO2 and H2O ? ( ) A .146 B. 120 C. 165 D.182 E. 19913. which is an intermediate on the pathway for synthesis of ketone bodies and cholesterol?A .malonyl CoA

7、B. acetoacetyl-CoA C. HMGCoA D. acetyl-CoA E. acetoacetate14. which is prosthetic group of acetyl-CoA carboxylase?A . NAD+ B. biotin C. NADP+ D. FAD E. FMN15. which is the key enzyme in the regulation of cholesterol synthesis? ( )A . HMGCoA synthase B. squalene monooxygenase C. HMGCoA reductase D. s

8、qualene synthase E. HMGCoA thiolase16.which is the correct sequence of 4 reactions in fatty acids oxidation?A . dehydrogenation, redegydrogenation, hydration, thiolysis B. thiolysis, dehydrogenation, redegydrogenation, hydrationC. dehydrogenation, hydration, redegydrogenation, thiolysis D. hydration

9、, dehydrogenation, thiolysis, redegydrogenationE. dehydrogenation, thiolysis, redegydrogenation, hydration17. which is the major form that transports endogenous TAGs from the liver to the tissues?A .HDL B. LDL C.VLDL D.CM E. IDL18. which lipoprotein contains apoB100 mostly?A .HDL B. LDL C.VLDL D.CM

10、E. CM remnants19. which lipoprotein contains apoB48 mostly?A .HDL B. LDL C.VLDL D.CM E. IDL 20. which enzyme s activator is apo C?A .LPL B. LCAT C.ACAT D.HL E. CETP 21. the net result of the oxidation of 1 mol palmitic acid (16C) will be ( ) mol ATP?A .129 B. 96 C. 165 D.182 E. 106 22.which is the m

11、ajor form that participates in the reverse cholesterol transport?A . IDL B. HDL C. LDL D. VLDL E. CM 23.which is the rate limiting enzyme in the TAG degradation?A .HSL B. LPL C.DAG lipase D.HL E. MAG lipase 24.which hormone can accelerate fat mobilization?A .epinephrine B.glucagons C.TSH D.ACTH E. a

12、ll above25.which is anti-lipolytic hormone ?A .epinephrine B.glucagons C.TSH D.ACTH E. prostaglandin E226.which is essential fatty acid?A . stearic acid B. oleic acid C.linoleic acid D. palmitic acid E. oxaloacetic acid27.which is the pathway that acetyl-CoA is transported from the mitochondria into

13、 the cytosol to allow FA synthesis to occur?A . TAC cycle B. malate-asparate shuttle C.glucose pyruvate cycle D. citrate pyruvate cycle E. -glycerophosphate shuttle28. which is the key enzyme in -Oxidation of Fatty Acids? ( )A . carnitine acyl transferase B. carnitine acyl transferase C. acyl-CoA sy

14、nthetase D. carnitine-acylcaritine translocase E. acetyl-CoA carboxylase29. the lack of ( ) means that ketone bodies are synthesized exckusively in the liver and must be used elsewhere.A . HMGCoA synthase B. succinyl CoA transsulfurase C. HMGCoA reductase D. acetoacetyl-CoA thiolase E. HMGCoA thiola

15、se30. which agent is an inhibitor of electron transport at Complex ?A .rotenone B. antimycin A C. piericidin A D. amobarbital E. DNP31. which agent is not an inhibitor of electron transport at Complex ?A .carbon monoxide B. azide C. sulfureted hydrogen D. amobarbital E. cyanide32. which is not the e

16、nergy-rich compound?A .CP B. ATP C. PEP D. 1,3-bisphoglycerate E. 2,3-bisphoglycerate 33.the sequence of cytochrome in respiratory chain is :A. c-c1-b-aa3-O2 B. c1- c -b-aa3-O2 C. b -c1- c -aa3-O2 D. b - c - c1 -aa3-O2 E. c- b - c1 -aa3-O2 34. Which of the following state is nitrogen equilibrium?A.

17、advanced cancer patient B. pregnant women C. patient recovering from illness D. people suffer form long-time hunger E. normal adult35. Which of the following state that nutrition sufficicent infant in?A.nitrogen balance B.positive nitrogen balance C.netative nitrotgen balance D. nitrogen equilibrium

18、 E.none of the above36. Which of the following state is positive nitrogen balance?A.advanced cancer B. pregnant women C.people suffer from fever D. people suffer form long-time hunger E.normal adult37. Which of the following is not one carbon unit?CH3; CH2; CO2; CH; CHO38. Which of the following is

19、not produced by Tyr?norepinephrine;epinephrine;dopamine; Phe;melanin39. Which of the following is the main deamination style in muscle?Transamination;ornithine cycle;L-glutamate oxidation deamination;purine nucleotide cycle;-glutamyl cycle40. Which of the following is the storage and transportation

20、style of ammonia?Glu; Tyr;GSH; Asn; Gln41. Which of the following is the main outlet of ammonia in mammalian? infiltrate to intestinaltract;synthesis of Gln;synthesis of urea in liver;synthesis of amino acid again; excrete out of the body in kidney42. Which of the following amino acid can not produc

21、e one carbon unit?Serine;Valine ;Tryptophan;Histidine ;Glycine 43.Which of the following ammino acids take part in the synthesis of creatine?Glycine,mehionine,arginine; Methionine,ornithine,citrulline; Glycine,methionine,citrulline; Glycine,arginine,ornithine;Ornithine,citrulline, arginine 44. Which

22、 of the following is the carrier of one carbon unit ? biotin; SAM; FH4; FH2; folic acid45. Which of the following is ketogenic amino acid only?Glycine; Leucine; Threonine; Isoleucine; Tyrosine46. Which of the following are the nitrogen source of urea ?carbomoyl phosphate and aspartate ;carbomoyl pho

23、sphate and ornithine; -amino group and-amino group of ornithine;-amino group of citrulline and-amino group of arginine;-amino group of ornithine and glycine47. Which of the following amino acid can produce PAPS? taurine; methionine; cysteine; homocysteine; glutamate48. Which of the following is the

24、main deamination style in the body?oxidation deamination; reduction deamination;direct deamination; transamination; union deamination49. Which of the following is the process that transport ammonia from muscle to liver? TAC cycle;ornithine cycle;alanine-glucose cycle;methionine cycle ; -glutamyl cyc

25、le50. Which of the following vitamin that the coenzyme of amino acid decarboxylase contain? C; B2; B12;B6;B151. Which of the following is the direct donor of CH3? N5-CH3-FH4; SAM; N5,N10- CH2-FH4; N5,N10=CH-FH4; FAD52. Which of the following is ketogenic and glucogenic amino acid ?Ala; Phe; His; Pro

26、; Leu53. Which of the following is the main source of ammonia in kidney?union deamination of amino acid; hydrolysis of Gln;hydrolysis of urea ; nonoxidative deamination of amino aicd;oxidation of amine54. In the synthesis of urea, one N come from NH3, which of the following amino acid provide anothe

27、r N for urea? Pro; Asp; Glu; Phe; Lys55. Which of the following is first synthesized in the process of de novo synthesis of purine nucleotide?GMP; AMP; IMP; ATP; GTP56. Which of the following is the end product of purine nucleotide catabolic metabolism? urea; creatine; creatinine; uric acid; -alanin

28、e57. Which of the following substance directly link nucleotide synthesis and glucose metabolism?glucose; glucose-6-phosphate ; glucose-1-phosphate ; glucose-1,6-diphosphate; ribose-5-phosphate58. Which of the following is not the direct material of de nove synthesis of purine nucleotide ? glycine; a

29、spartate ; glutamate ; CO2 ; one carbon unit59. Which of the following material could provide C4 and C5 for purine ring?alanine; glycine; glutamate ; aspartate ; glutamine60. Which of the following provide only one C atom for purine synthesis?CO2; glutamine; glycine; aspartate; formic acid61. Which

30、of the following provide two N atoms for pyrimidine ring? glutamine and ammonia ; glutamine and glutamate glutamine and carbomoyl phosphate; aspartate and carbomoyl phosphate; aspartate and glutamate 62.Which of the following is the common material for the synthesis of pyrimidine and purine nucleoti

31、de?fumarate; glutamine ; formic acid ; asparagine; glycine63. Which of the following amino acid totally participate in the synthesis of purine nucleotide?glycine ; aspartate; glutamate ; glutamine ; asparagines64.Which of the following provide C2 for purine ring? N5-CH3FH4; N10-CHO-FH4;N5，N10=CH-FH4

32、; N5，N10-CH2-FH4; CO265. Which of the following is the energy source of brain for long-term starvation patient ? glucose; amino acid; glycerol; acetone body; glucogen66. Which of the following is not correct about chemical modification of key enzyme?the enzyme have two style: active and inactive ; t

33、he active style and inactive style can be interconverted by the other enzyme ; the enzyme that catalyze the interconversion can be controlled by the hormon; do not need energy; phosphorylation and dephosphorylation is the main style67. Which of the following is the main style of chemical modificatio

34、n?methylation and demethylation ; acetylation and deacetylation ; phosphorylation and dephosphorylation; polymerization and depolymerization ; synthesis and decomposition of enzyme68. Which of the following reaction take place in plasma?TAC ; oxidative phosphorylation ; pyruvate carboxylation ; -oxi

35、dation of fatty acid ; synthesis of fatty acid69. In the condition of starvation, which of the following is not correct? insulin secretion is enhanced ; glucagon secretion is enhanced ;fat mobilization is enhanced ; synthesis of acetone body is enhanced ; glyconeogenesis is enhanced70. Which of the

36、following is not correct about the substance metabolism in different tissues and organs ? liver is the hinge of the substance metabolism; glucose decomposition in heart is mainly aerobic oxidation ;the energy of brain usually come from glucose ;the energy of red cell usually come from glycolytic pat

37、hway;liver is the only organ that have the reaction of glyconeogenesis71. Which of the following is not correct about the allosteric regulation ? the allosteric enzyme usually has two subunits ; the allosteric effectors usually are small materials ;the allosteric effectors usually bind to the site o

38、ut of the active center of the enzyme ; the end production of the pathway usually is the allosteric inhibitors of the enzyme that catalyze the initiation reaction of the pathway ; can be amplified72. Which of the following is not correct about the key enzyme? the key enzyme usually catalyze the firs

39、t reaciton of the metabolic pathway ; the key enzyme has the highest activity; the key enzyme usually is the allosteric enzyme ; the key enzyme usually is regulated by hormone; the reaction that catalyzed by the key enzyme usually is the one-way reaction or equilibrium reaction73. Which of the follo

40、wing enzyme do not belong to chemical modification enzyme ? phosphorylase; glycogen synthetase; pyruvate kinase; malate dehydrogenase ; phosphorylase b kinase74. Which of the following metabolic pathway take place in the mitochondira?glycolytic pathway; the synthesis of acetone body; pentose phospha

41、te pathway ; the synthesis of the fatty acid ; the synthesis of the glycogen75. Which of the following is the material of glyconeogenesis for short time starvation?glycerol ; glycerol-3-phosphate; alanine; pyruvate; lactate76. In the oxidation decomposition of glucose ，fat and amino acid , which is

42、the main compound that go into the TAC cycle?isocitrate ; pyruvate ; -ketoglutarate ; -keto acid ; acetyl CoA77. Which of the following is not the outlet of Acetyl CoA?go into the TAC cycle ; use to synthesize fat ; transition ot ketogenic amino acid ; transition ot acetone body; transition to chole

43、sterol78. Which of the following is the rate-limiting enzyme of glyconeogenesis ?Acetyl CoA carboxylase ; 7-hydroxylase; HMGCoA reductase; pyruvate carboxylase; 6-phosphofructokinase-179. Which of the following does not participate in DNA replication?helicase; single strand binding protein; transcip

44、tion factor; ligase ; primase80. DNA replication is a ( ) process.conservative; destructive; non-conservative; semi- conservative, random dipersive81. he primary structure of DNA is the squence of its nucletide residues connected by ( )?3,5-phosphodiester bonds; hydrogen bonds; peptide bonds; salt b

45、onds; disulfide bonds82. When the two daughter strands of DNA replicated , ( )one strand in the 5 to 3 and the other in the 3 to 5direction; the both strands are all in the 3 to 5 direction; the both strands are all in the 5 to 3 direction; the both strands are all conservative replicated; the DNAsy

46、nthesis of leading strand is continuous 83Which one can separate the parental DNA strands? DnaC; DNA-pol; topoisomerase; primase ; helicase84Human telomerase RNA is one of the ( ).reverse transcriptase ; DNA-pol; RNA-pol; DNA ligase; DNA topoisomerase85Which of these enzyme is not concerned with DNA replication？DNA dependent DNA polymerase; DNA dependent RNA polymerase; RNA dependent DNA polymerase; topoisomerase; DNA ligase86In the initiation of DNA replication, the proper order that following enzyme and p