脑出血血肿吸收时间 大鼠脑出血血肿周围半暗带及其时间窗的探讨.docx

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1、脑出血血肿吸收时间 大鼠脑出血血肿周围半暗带及其时间窗的探讨 中图分类号:R743.3 文献标 识码:A 文章编号:1009_816X(2010)04_0270_03 DOI:10.3969/j.issn.1009_816X.2010.04.07 Explore the Intracranial Hematoncus Penumbra and Time Window in Rats. TIAN Wei,ZHAO Qiang,GAO Chang, et al. Department of Neurology, Ningbo development zone s central hospital,

2、 Zhejiang 315800, China Abstract ObjectiveTo study penumbra of perihematoma and the time window in r at model of intracerebral hemorrhage.MethodsWe used coagulated autologous blo od to establish the rat model of intracerebral hemorrhage and employed TTC and H E staining to identify normal tissue、isc

3、hemic tissue、and necrotic foci. Theischemic scope and necrotic scope were analyzed quantitatively by image analysi s technique. Furthermore, the time window of perihematoma penumbra area was dete rmined by statistical analysis of perihematoma penumbra area at different time g roups.Results It sugges

4、ted that penumbra index would gradually reduce with theincrease of post hemorrhage time according to groups of 2h、3h、4h and 6h in r at model of intracerebral hemorrhage, the penumbra index was significantly lowerin 6h group than in 2h and 3h groups (P 参考文献 1Astrup J, Symon L, Branston MM, et al. Cor

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8、nd Functional Re const runruction, November,2006,1(4):130. 7陈彦克,陈衔城.自发性脑出血动物模型J.国外医学•脑血管分册,2004,12(8):576 -6781. 8Sinar EJ, Mendelow AD, Graham DI, et al. GM. Experimental intracerebral he morrhage: effects of a temporary mass lesionJ. J Neurosurg,1987,66(4):568- 576. 9Kingman TA, Mendelow AD, Graham DI, et al. Experimental intracerebral mass:time_related effects on local cerebral blood flowJ. J Neurosurg,1987,67(5 ):732-738.