子宫平滑肌瘤精品文稿.ppt

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1、子宫平滑肌瘤第1页，本讲稿共53页Introduction vUterine enlargement as a result of leiomyoma is common in clinical practice.vMyoma are the commonest new growths of the uterus and one of the most common tumors of the human body.vThese occur in approximately,20%of women over 30,25%of women over 40.第2页，本讲稿共53页Aetiologi

2、cal factorsvFemale Hormones Estrogens Progestrons vGrowth Factors Basic fibroblast growth factor(BFGF).Insulinlike growth factor(IGF)-I.Epidermal growth factor(EGF).第3页，本讲稿共53页Anatomy of uterus第4页，本讲稿共53页Classification第5页，本讲稿共53页ClassificationvAccording to location of uterine myomata have been divid

3、ed in vCorporeal fibromyomata(90%)vCervical myomata(10%).第6页，本讲稿共53页ClassificationvAnd corporeal myomata have been divided:vIntramural fibromymata 60-70%vSubserous fibromymata 20%vSubmucous fibromymata 10-15%第7页，本讲稿共53页第8页，本讲稿共53页ClassificationvIntramural fibromymata with intramural fibromyomata enl

4、argement of the uterine body usually occurs,often with elongation of its cavity so that there is increased menstrual loss.第9页，本讲稿共53页Classification Subserous fibromymata vSize:from small nodules to enormous masses of 20 kg or more in weight.vPedunculated myoma:they tend to grow up into the abdomen a

5、nd the broad ligament,vRarely torsion may occur,resulting in interference with the blood supply to the tumor.第10页，本讲稿共53页ClassificationvSubmucous fibromyoma.Some intramural tumors are extruded towards the uterine cavity.vThe uterus contracts in an attempt to expel the tumor and it may be extruded un

6、til it is only attached to the uterine wall by a stalk and is known as a fibro-myomatous polyp 第11页，本讲稿共53页PathologyvNacked eye appearance.on section the fibromyoma is paler,harder and more fibrous than the uterine wall.vOn comparing an intramural tumor with the surrounding false capsule of uterine

7、wall the difference is well marked.第12页，本讲稿共53页Nacked eye appearance第13页，本讲稿共53页Smooth muscle tumors of the uterus are often multiple.Seen here are submucosal,intramural,and subserosal leiomyomata of the uterus.第14页，本讲稿共53页PathologyvMicroscopical structure.These growths are composed of unstriped mus

8、cle and fibrous tissue第15页，本讲稿共53页Here is the microscopic appearance of a benign leiomyoma.Normal myometrium is at the left,and the neoplasm is well-differentiated so that the leiomyoma at the right hardly appears different.Bundles of smooth muscle are interlacing in the tumor mass.第16页，本讲稿共53页Degen

9、erationvThese tumors grow slowly;in some cases there may be no evident change in size for many years.vIn a few cases growth is more rapid and secondary changes may also cause swelling of the tumor.第17页，本讲稿共53页DegenerationvHyaline degeneration is the commonest change seen in fibromyomata.It is caused

10、 by a gradual inadequacy of the blood supply.vCystic degeneration is not uncommon,especially after the menopause,and is due to liquefaction of the areas of hyaline change.第18页，本讲稿共53页DegenerationvRed degeneration.In this variety of degeneration the affected area is stained red and resembles raw meat

11、.It is most freguently seen during the pregnancy and in postpartum.第19页，本讲稿共53页Degeneration Malignant change vIn 0.1to 1%of cases,malignancy as leiomyosarcoma may develop.It is most likely to be seen in large tumors.vMalignancy is more typical in older patients,especially postmenopausal patients vPr

12、esention with rapidly enlarging uterine mass and postmenopausal bleeding.vMetastasis occurs rapidlly in these cases.第20页，本讲稿共53页This is a leiomyosarcoma protruding from myometrium into the endometrial cavity of this uterus that has been opened laterally so that the halves of the cervix appear at rig

13、ht and left.Fallopian tubes and ovaries project from top and bottom.The irregular nature of this mass suggests that is not just an ordinary leiomyoma.第21页，本讲稿共53页SymptomsvBleeding is the most common presenting symptom in uterine fibroids.vMenorrhagia is freguent reason for patients to seek advice.vT

14、he periods increase in amount and duration.第22页，本讲稿共53页SymptomsvBleeding vSubmucous fibromyomata menorrhagia is nearly always present,and quite small tumors can lead to severe anaemia.vIntramural tumors may increase the lossvSubserous growths do not affect the menstrual loss.第23页，本讲稿共53页SymptomsvBle

15、eding vMechanisms for increased bleeding:vAlteration of normal myometrial contractile functionvInability of the overlying endometrium to respond to the normal E/P menstrual phases.vPressure necrosis of the overlying endometrial bed.第24页，本讲稿共53页SymptomsvAn abdominal tumour is sometimes the first thin

16、g that the patient notices.The tumor is not tender and rarely gives rise to pain.vDischarge is rarely a prominent symptom except during the extrusion of fibromyomatos polyp through the cervical canal.第25页，本讲稿共53页SymptomsvPain is not a common symptom.vwhen it occur it is generally an indication that

17、there is associated vendometriosis vor pelvic inflammatory disease,vor some complication of the tumor such as red degeneration or torsion.第26页，本讲稿共53页SymptomsvPelvic pressure:pressure on the bladder leading to frequency and retention of urine.第27页，本讲稿共53页Physical signsvThe physical signs vary with t

18、he size,position and number of the tumors.vA symmetrical enlargement of the uterus is found with a submucos growth.vMore often the enlargement is asymmetrical;it is often nodular on the surface because there are multiple tumor.vSubserous tumors with little myometrial covering often fell particularly

19、 hard.第28页，本讲稿共53页Physical signsvOn pelvic examination the cervix may be found to be pushed down or displaced to one side.If it is expanded by an intracervical tumor,or it may be dilated with the lower pole of a tumor left within it.第29页，本讲稿共53页DiagnosisvThe diagnosis of these tumors is usually made

20、 vby clinical examination,include abdominal and bimanual palpation,vor imaging studies.vIn addition,irregularities of the uterine cavity can be detected at the time of endometrial currettage.第30页，本讲稿共53页DiagnosisvPelvic ultrasound is the most commonly used for confirmation of uterine myomas.vDilatio

21、n and curettage may provide relevant information,because larger tissue specimens,including small submucous myomas,may be obtained.第31页，本讲稿共53页Pelvic ultrasound第32页，本讲稿共53页Pelvic ultrasound第33页，本讲稿共53页HysteroscopyvHysteroscopy may also be used to evaluate the enlarged uterus by directly visualizing t

22、he endometrial cavity.第34页，本讲稿共53页Differential diagnosisvOther conditions which cause menorrhagiavDysfunctional uterine bleedingvCarcinoma of the uterusvEndometrial polyp of uterusvOther conditions which give rise to a swelling in the pelvisvAdenomyoma,ovarian tumors,inflammatory swelling in the pel

23、vis,pregnancy 第35页，本讲稿共53页This uterus has been opened anteriorly through cervix and into the endometrial cavity.High in the fundus and projecting into the endometrial cavity is a small endometrial polyp.Such benign polyps may cause uterine bleeding.第36页，本讲稿共53页The thickened and spongy appearing myom

24、etrial wall of this sectioned uterus is typical of adenomyosis.There is also a small white leiomyoma at the lower left.第37页，本讲稿共53页第38页，本讲稿共53页This adenocarcinoma of the endometrium is more obvious.Irregular masses of white tumor are seen over the surface of this uterus that has been opened anterior

25、ly.The cervix is at the bottom of the picture.This enlarged uterus was no doubt palpable on physical examination.第39页，本讲稿共53页Abnormality of uterus第40页，本讲稿共53页TreatmentvFollow up vhormonal treatment vfibroid embolisation vSurgical management 1.hysterectomy 2.myomectomyvmyolysis第41页，本讲稿共53页TreatmentvF

26、ollow up:the majority of patients with uterine myomas do not require surgical treatment.vSmall tumors and not causing symptomsvPatients in the late reproductive or perimenopausal years.vManagement:repeat pelvic exminations and assisted by serial pelvic ultrasound measurements vEvery 3-6 months.第42页，

27、本讲稿共53页TreatmentvDrug therapy:bleeding is not heavy enough to cause anemia and small myoma.vMechanisms:vPharmacologic inhibition of estrogen secretionvAn attempt may be made to minimize uterine bleeding vThis treatment is commonly used for 3 to 6 months.第43页，本讲稿共53页TreatmentvDrugsvandrogen vGnRH-a s

28、upplementation.vGestrinonevMifepristonevChinese medicine第44页，本讲稿共53页TreatmentSurgical treatment is indicated in cases with:1.Heavy or prolonged bleeding2.Tumors of large size over 2.5 gestation months,even if these are not causing symptoms.3.Possible malignant change,such as a tumor which grows afte

29、r the menopause.4.Pressure symptoms,pressure against bladder,bowel,and pelvic floor.5.Tumors which have undergone torsion第45页，本讲稿共53页TreatmentvSurgical forms:vMyomectomy is occasionally warranted in younger patients whose fertility is compromised by the presence of myomas.vHysterectomy:although hyst

30、erectomy is commonly performed for uterine myomas,it should be considered as definitive treatment only in symptomatic women who have completed childbearing.第46页，本讲稿共53页第47页，本讲稿共53页第48页，本讲稿共53页第49页，本讲稿共53页Uterine Fibroid Embolization(Uterine Artery Embolization)第50页，本讲稿共53页Uterine Fibroid Embolization(Uterine Artery Embolization)第51页，本讲稿共53页第52页，本讲稿共53页第53页，本讲稿共53页