器官移植麻醉双语教案.ppt

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1、器官移植麻醉双语 Still waters run deep.流静水深流静水深,人静心深人静心深 Where there is life,there is hope。有生命必有希望。有生命必有希望Anesthesia for Kidney TransplantationKidneys are the most common major organ transplanted，the success of kidney transplantation，which is largely due to advances in immunosuppressive therapy，has greatly

2、improved the quality of life for patients with end-stage renal disease.2uIndications Patients with end-stage renal diseases and dependent on dialysis（透透析）析）for a long time.3uCharacteristic of Pathophysiology Changes of electrolyte and acid-base balance Water intoxication（水水中中毒毒），hyperkalemia（高高 钾钾），

3、hyponatremia（低低 钠钠），hypernatremia（高高 钠钠）and metabolic acidemia（代酸）（代酸）.4 Cardiovascular Hypertension（高高血血压压）Renal ischemia，sodium retention and abnormalities in the renin-agiotension system result in systemic hypertension.Uremic cardiac disease myocardiosis（心心肌肌 炎炎），pericarditis（心心 包包 炎炎），left ventr

4、icular hypertrophy）（左左 室室 肥肥 大大），coronary ischemia（冠冠 脉脉 缺缺 血血），angiosclerosis（血管硬化）（血管硬化）.5Potentialcongestiveheartfailure（潜在性充血性心力衰竭）（潜在性充血性心力衰竭）andpulmonaryedema（肺水（肺水肿）肿）arrhythmia（心律失常）（心律失常）6 Hematologic Bone marrow suppression,decreased erythropoietin production,decreased erythrocyte producti

5、on,increased deformation erythrocyte production and increased bleeding tendency Anemia(贫血贫血).Liver disease coagulation factor，Uremia(尿尿毒毒症症)and using of heparin coagulation disorder，bleeding time .7 Other changes Nausea（恶恶心心），vomit（呕呕吐吐），anorexia（厌厌食食），diarrhoea（腹腹泻泻），ascites（腹腹 水水）and gastric dilat

6、ation（胃扩张）（胃扩张）.Infection（感染）（感染）.Hypoproteinemia（低低 蛋蛋 白白 血血 症症），hyperglycemia（高血糖症）（高血糖症）.8u Evaluation and preparation before anesthesia Preanesthetic evaluation This assessment includes a patient history,a physical examination and any indicated lab tests,classifying the patient according to the

7、ASA physical status scale completes the assessment.9General condition Patients are often combined with hypoproteinemia,anemia,coagulation disorder and fluid,electrolyte and acid-base disturbance and so on.Concurrent diseases Cardiovascular,pulmonary,cerebral,hepatic and other diseases are commonly c

8、oexisted.Status of immunosuppression（免免疫疫抑抑制制）and infection（感染）（感染）.10Preanesthetic preparationCare of donor kidney Kidney should have good circulation perfusion before being separated from donor,warm ischemia time and cold ischemia time should be minimized,separated kidney should be frozen for pres

9、ervation in reason,transplanted kidney should have good perfusion after rebuilding circulation and renal function should be recovered in time.11Dialysis（透透 析析）is the most important preparation before operation.Dialysis often precedes transplantation to correct volume or electrolyte derangements.Hemo

10、dialysis（血血液液透透析析）is more effective than peritoneal dialysis（腹腹膜膜透析）透析）.12 Blood transfusion（输输血血）Blood transfusion should generally be given only to severely anemic patients(hemoglobin/血血色色素素 6-7g/dl)or when significant intraoperative blood loss is expected.Controlling infection.13Treatment of comp

11、lication（Hypertension,cardiac function ,fluid,electrolyte and acid-base disturbance and so on）Fasting（禁食）（禁食）Premedication（术前用药）（术前用药）Protection of arteries and veins fistula14uPrinciples of anesthesia managementPrinciples of anesthetics chosen Anesthetics not primarily dependent on renal excretion

12、for elimination，no nephrotoxicity（肾肾 毒毒 性性）and having short duration of action should be used.15 Venous anesthetics Propofol（异异丙丙酚酚）,Fentanyl（芬芬太太尼尼）,Midazolum（咪咪达达唑唑仑仑）,Etomidate（依依托托咪咪 酯酯）and small doses of Sodium pentothal（硫喷妥钠）（硫喷妥钠）are often used.Inhalational anesthetics Isoflurane（异异氟氟烷烷）,Enfl

13、urane（安安氟氟烷烷）,Nitrous oxide（笑笑气气）,Desflurane(地地氟氟烷烷)and sevoflurane（七七氟氟烷烷）are often used，methoxyflurane（甲甲 氧氧 氟氟 烷烷）is forbidden because of its nephrotoxicity.16 Muscle relaxants Atracurium（阿阿曲曲库库铵铵）,Rocuronium（罗罗 库库 溴溴 铵铵）and Vecuronium（维维库库溴溴铵铵）are often used，dont use succinylcholine（琥珀胆碱）（琥珀胆碱）.

14、Local asnesthetics Lidocaine,Bupivacaine,Rupivacaine and Dicaine are often used，notice toxicity reactions induced by excessive of local anesthetics,dont use epinephrine（肾上腺素）（肾上腺素）.17Postoperative analgesics Dolantin,tramal,fortanoryn,PCEA.Choice of anesthesia Principles No pain,muscle relaxed,sedat

15、ion perfectly,vital signs stable,no complications.1819Continuous epidural anesthesia for kidney transplantation is often used in China now.Choice of puncture sites,T11-12 or T12L1，L2-3 or L3-4 .20Advantage Having good muscle relaxation，avoiding side effects of muscle relaxants.Avoiding pulmonary inf

16、ection induced by endotracheal intubation.Avoiding depression to respiration and circulation if the block level is well controlled.21Disadvantage Mental stress,Epidural hemorrhage（出出血血）and hematoma（血血肿肿）(direct pressure and ischemia to spinal cord ),Circulation and respiration depression(if the bloc

17、k level is inadequate controlled).22General anesthesia combined intravenous and inhalational anesthesia is often used.Combined spinal and epidural anesthesia23Intraoperative monitoring and anesthetic management Monitoring Includes ECG,Blood pressure,SPO2,Temperature,Electrolyte,Blood gas analysis an

18、d urinary output，monitoring direct intra-arterial blood pressure and CVP if it is necessary.24 Anesthetic management Prevention and cure of hypotension Prevention and cure of hypertension Monitoring serum kalium Urinary output Drugs 25Venous road 1 5%Glucose 250ml/iv by drip DXM 75 mg/iv by drip(306

19、0)5%Glucose 250ml/iv by drip Lasilix（速速尿尿）80mg iv when starting to anastomose renal artery 20%Mannitol（甘甘露露醇醇）250 ml iv by dvip(fast)as soon as blood vessel is anastomosed26 5%Glucose 250ml/iv by dvip DXM 75mg/iv by drip(3060)5%Glucose 250ml/iv by dvip 0.9%NS 250ml/iv by dvip 10%kcl iv when patient

20、has diuresis（多尿）（多尿）27Venous road 2 Blood transfusion should be given and Dopamine 2 3g/kg.min iv by drip when it is necessary to enhance 1020mmHg of pressure before rebuilding circulation.Maintenance of intravenous fluids is decided by anesthetist.28Postoperative management Sterilize Avoid anoxia，p

21、revent and cure respiratory airway complications Recover the function of transplanted kidney as soon as possible Postoperative pain management29Transfuse albumin1020g each day，correct acid-base and electrolyte disorder.Resist infection.Diagnose,prevent and cure rejection response immunosuppressant drug(Cyclosprine,Azathioprine and Prednisone).30Thank you!31