北大神经生物学课件2绪论ppt课件.ppt
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1、北大神经生物学课件2绪论ppt课件 Still waters run deep.流静水深流静水深,人静心深人静心深 Where there is life,there is hope。有生命必有希望。有生命必有希望Effect of HANS on heart rate of heroin addictsDay of treatment1234567891060708090100110120130Control2 Hz2/100 Hz100 Hzn=13-16*Heart Rate(beat/min)Body Weight(kg)01234567891011Days of Treatment4
2、5505560Control2Hz2/100Hz100Hz(n=26-32)Effect of HANS on Body Weight during Opiate Withdrawal*The dose of The dose of BPNBPN needed by Heroin Addicts needed by Heroin Addicts during detoxification during detoxificationBPN Dose(BPN Dose(mg/dmg/d)1 12 23 34 45 56 67 78 89 91010 11111212 1313 1414Days o
3、f Treatment Days of Treatment (n=14)(n=14)0.00.00.50.51.01.01.51.52.02.02.52.5*BuprenorphineBuprenorphine HANS+BPN HANS+BPN *P0.001,compared with BPN group *P0.001,compared with BPN group CRAVING:the most difficult issue一朝吸毒,终身想毒。1 Month 1 Month0 05050100100Relapse Rate(%)Relapse Rate(%)*P0.05,compa
4、red with BPN group *P0.05,compared with BPN group 92%92%78%78%57%57%71%71%100%100%100%100%HANS Decreases Heroin Relapse Rate of the Heroin addicts 2 Month 2 Month 3 Month 3 MonthBPN(n=12)BPN(n=12)HANS+BPN(n=14)HANS+BPN(n=14)*The auto-track conditioned place preference(CPP)instrumentMorphine-induced
5、conditioned place preference(CPP)Dose-dependent effect*p0.05,*p0.01,*p 100 Hz100 Hz 2 HzElectroacupuncture treatment for drug addictionVTAOpiateGABANAcDADATCocaineEuphoriaEnkDynElectroacupuncture2 Hz100 HzPresynaptic inhibitionSubstitutionA100 bp2000 bp1000 bp750 bp500 bp250 bpDL 2000 NSCPP2 Hz100 H
6、zrestrainGAPDH(532 bp)PPD(250 bp)Effect of 100Hz EA on the level of PPD mRNA in NAc of CPP rats B0.00.51.01.5Grey scale ratios(PPD/GAPDH)Treatment*#n=4NSCPP2 Hz100 HzrestrainEffect of 2Hz EA on the level of PPE mRNA in NAc of CPP rats Grey scale ratios(PPE/GAPDH)0.000.250.500.751.00NSCPP*#2 Hz100 Hz
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