药学英语之减肥药原理讲解.ppt

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1、Generic Name:Sibutramine hydrochlorideProduct Name:Reductil/Ectiva Product name:Qu MeiGeneric Name:Sibutramine hydrochloride SibutramineFormula:C17H26Cl N molecule Chemical structure Indications:obesity(肥胖症，多脂肥胖症，多脂)！pharmacologySibutramine is a neurotransmitter(神经递神经递质质)reuptake（重吸收）（重吸收）inhibitor

2、that reduces the reuptake of serotonin（血清素（血清素),norepinephrine（去甲肾上腺素）（去甲肾上腺素）,and dopamine,thereby increasing the levels of these substances in synaptic clefts（突触间隙）（突触间隙）and helping enhance satiety（饱满感）（饱满感）;the serotonergic（5-羟羟色胺能）色胺能）action,in particular,is thought to influence appetite.contrai

3、ndicationsSibutramine is contraindicated in:1 Psychiatric(精神病学的精神病学的)conditions as bulimia nervosa（神（神经性贪食症）经性贪食症）,anorexia（厌食症）（厌食症）,serious depression or preexisting mania（狂躁症）（狂躁症）2 Patients below 18 years of age 3 Concomitant（伴行的，并发的）（伴行的，并发的）treatment with a MAO inhibitor（单胺氧化酶抑制剂）（单胺氧化酶抑制剂）,an

4、tidepressant or other centrally active drugs,particularly other anoretics（消瘦剂，（消瘦剂，减食欲剂）减食欲剂）4 Hypertension that is not sufficiently controlled(caution in controlled hypertension)5 Existing pulmonary hypertension（肺动脉高血压）（肺动脉高血压）6 Pregnant and lactating（泌乳）（泌乳）women side effects!Frequently encountere

5、d side effects areFrequently encountered side effects are:dry mouth,paradoxically increased appetite,nausea(恶心恶心),strange taste in the mouth,upset stomach,constipation（便秘）（便秘）,trouble sleeping,dizziness,drowsiness（困倦）（困倦）,menstrual cramps/pain,headache,flushing（面红）（面红）,or joint/muscle pain.The follo

6、wing side effects are infrequent but serious and require immediate medical attention:cardiac arrhythmias（心律不齐）（心律不齐）,paresthesia（感觉异常）（感觉异常）,mental/mood changes(e.g.,excitement,restlessness,confusion,depression,rare thoughts of suicide).Symptoms that require urgent medical attention are seizures（癫痫发

7、作）癫痫发作）,problems urinating（排尿）（排尿）,abnormal bruising（碰伤）（碰伤）or bleeding,hematemesis（呕血）（呕血）,fever and rigors（僵（僵直）直）,chest pain,hemiplegia,（半身不遂）（半身不遂）abnormal vision,dyspnea（呼吸困难）（呼吸困难）and edema.（水肿）（水肿）Suggestion!Dont take QU Mei or any kind of medicine whose main ingredient is Sibutramine.More exercise and less food is the golden key for losing weight.If some medicine must be taken for helping losing weight,I recommend Wei Ting.