转化生长因子-β1论文：2型糖尿病肾病患者血清TGF-β1和PDGF-BB水平与尿白蛋白排泄率的相关性研究.doc

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1、转化生长因子-1论文：2型糖尿病肾病患者血清TGF-1和PDGF-BB水平与尿白蛋白排泄率的相关性研究【中文摘要】2型糖尿病(T2DM)患者血清转化生长因子1 (TGF-1)和血小板衍化生长因子-BB(PDGF-BB)水平与尿白蛋白排泄率间的关系,探讨TGF-1和PDGF-BB在糖尿病肾病(DN)的发生开展中的作用。方法研究对象共120例。其中健康对照组(NC, UAER20g/min) 60例,2型糖尿病组90例,将其分为正常白蛋白尿组(NA, UAER200g/min)各30例,测定血压(SBP/DBP)、体重指数(BMI)、空腹血糖(FPG)、空腹C肽(FCP)、糖化血红蛋白(HbA1c

2、)、尿白蛋白排泄率(UAER)及TGF-1、PDGF-BB水平。结果NC、NA、MA、ODN组血清TGF-1水平逐渐增高,T2DM各组血清TGF-1水平均显著高于NC组(Sig=0.0000.037,P0.05),ODN组显著高于NA组和MA组(Sig=0.000,P0.05)。T2DM各组的血清PDGF-BB水平均显著高于NC组(Sig=0.000,P0.05), MA组显著高于NC组和NA组(Sig=0.000,P0.05)。所有对象血清TGF-1和PDGF-BB水平与病程、BMI、SBP、DBP、FBG、FCP、HbA1c、BUN、Cr和UAER均呈正相关(r=0.0750.798,P0

3、.01)；与FCP呈负相关(r=-0.602-0.818, P0.01); TGF-1和PDGF-BB水平呈正相关(r=0.470,P0.01)。结论TGF-1介导了DN的病变发生,PDGF-BB在DN的早期致病作用尤为显著,二者在DN开展的不同阶段协同作用,加剧DN进展。【英文摘要】To investigate the relationship between the levels of Transforming growth factor-betal(TGF-1) and Platelet derived growth factor-BB(PDGF-BB) in serum and uri

4、nary albumin excretion rate in type 2 diabetes mellitus (T2DM), explore the role of TGF-1 and PDGF-BB in the development of diabetic nephropathy.Method The subjects were 120 cases. One healthy control group (NC, UAER 20g/min) 60 cases,90 cases of type 2 diabetic patients were divided into normal alb

5、uminuria group (NA, UAER 200g/min) of the 30 cases, measured blood pressure (SBP/DBP), body mass index (BMI), fasting blood glucose (FPG), Fasting C peptide (FCP), glycosylated hemoglobin (HbA1c), albumin excretion rate (UAER), TGF-1, PDGF-BB levels.Results NC, NA, MA, ODN TGF-1 levels in serum grad

6、ually increased, type 2 DM patients in each group of serum TGF-1 were significantly higher than that of NC group (Sig=0.0000.037, P0.05), ODN was significantly higher than NA group and MA group (Sig=0.000, P0.05). Type 2 DM patients in each group of serum PDGF-BB were significantly higher than that

7、of NC group (Sig=0.000, P0.05), MA was significantly higher than that of NC group and the NA group (Sig=0.000, P0.05). All objects of serum TGF-1 and PDGF-BB level and duration, BMI, SBP, DBP, FBG, FCP, HbAlc, BUN, Cr, and UAER was positively correlated (r=0.0750.798, P0.01); and FCP negative Correl

8、ation (r=-0.602-0.818, P0.01); TGF-1 and PDGF-BB level was positively correlated (r=0.470, P0.01).Conclusions Mediated by TGF-1 throughout the DN of the lesions, PDGF-BB in the early pathogenic role of DN is particularly significant, both in different stages of DN development of synergies, increased

9、 DN progress.【关键词】转化生长因子-1 血小板衍化生长因子-BB 糖尿病肾病 尿白蛋白排泄率 2型糖尿病【备注】索购全文在线加好友 ：13993八八四八同时提供论文辅导写作和论文发表委托效劳。【英文关键词】Transforming growth factor-1 platelet derived growth factor-BB diabetic nephropathy urinary albumin excretion rate Type 2 diabetes mellitus【目录】2型糖尿病肾病患者血清TGF-1和PDGF-BB水平与尿白蛋白排泄率的相关性研究摘要2-3Abstract3引言6-7材料与方法7-121.1. 研究对象7-8 病例选择标准7-8.1 DM的诊断标准7.2 排除病例标准7.3 健康对照组选择标准7.4 研究对象分组7-81.2. 研究方法8 一般资料的测量8 主要实验仪器81.3. 实验方法8-11 样本的采集8-9 生化指标测定9 HbA1c的测定9 UAER的测定9 血清中TGF-1、PDGF-BB的测定方法9-111.4 计算样品浓度111.5 统计学方法11-12结果12附图表12-17讨论17-20结论20-21参考文献21-22综述22-33参考文献30-33攻读学位期间的研究成果33-34致谢34-35