结核性脑膜炎英文精选文档.ppt

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1、结核性脑膜炎英文本讲稿第一页，共四十七页EPIDEMIOLOGY-TBM Tuberculous Meningitis(TBM)u The younger the children,the more readily to develop TBM.u 60%in Children aged 1-3 yearsu Death rate:15-30%2本讲稿第二页，共四十七页TBM(Tuberculous meningitis)u TBM is the most serious complication of tuberculosis in children and is usually fatal

2、 without treatment.u TBM always be a part of systemic disseminated tuberculosis.u TBM often occurs within 1 year of initial infection,especially in the first 2 to 6 months of infection.3本讲稿第三页，共四十七页Tuberculous BacilliPrimary ComplexBacteremiaRich FociSubarachnoid SpaceBrain or Spinal Cord Perenchyma

3、TuberculomasMeningitisPATHOPHYSIOLOGYTrauma/Diseases measles,pertussis Miliary TB4本讲稿第四页，共四十七页PATHOLOGICAL EFFECTSMeningesuDiffuse HyperemiauEdemauInflammatory Exudates uConformation of Tubercles 5本讲稿第五页，共四十七页PATHOLOGICAL EFFECTSSubarachnoid SpaceuA large amount of thick gelatinous exudates concentr

4、ate to the pavimentum cerebri,optic chiasma,bridge of varolius,bulbus rhachidicus and Sylvian fissure.u Basal meningitis accounts for the frequent dysfunction of cranial nerves III,VI,and VII.6本讲稿第六页，共四十七页PATHOLOGICAL EFFECTSCerebral ParenchymaTuberculous meningoencephalitisuswelling and hyperemia o

5、f the parenchyma contribute to the intracranial hypertension,then ischemia of parenchyma occur,finally lead to the foci of encephalomalacia and necrosis.Hemiplegia may be present because of this change.uMeninges,spinal,and spinal nerve root also involvement.The later always leads to paraplegina.7本讲稿

6、第七页，共四十七页PATHOLOGICAL EFFECTSCerebral VesselsuThe bacteria invade the adventitia directly in the early stage and initiate the process of acute vasculitis.uProgressive destruction of adventitia,disruption of elastic fibers,and finally intimal destruction(endoarteritis),lead to the obliterative vascul

7、itis,which may facilitate the ischemia,encephalomalacia and necrosis of parenchyma.8本讲稿第八页，共四十七页Circulation of CSFChoroid plexusLateral ventricleInterventricular foramenthe 3rd ventricleCerebral aqueduct4th ventricle2 Lateral foramina1 Medial foramenSubarachnoid spaceArachnoid granulationsDural sinu

8、sVenous drainage9本讲稿第九页，共四十七页PATHOLOGICAL EFFECTSHydrocephalusHyperemia of choroids overproduction of CSF Inflammatory adherence of Meningedefective absorption of CSF Communicating hydrocephalus CSF flow is obstructed on the route before the cerebral aqueduct and the 4th ventricleNoncommunicating hy

9、drocephalus10本讲稿第十页，共四十七页In tuberculous meningitis there is a tendency for the exudate to be primarily located on the under surface of the brain,particularly over the ventral surface of the brain stem.11本讲稿第十一页，共四十七页CLINICAL MANIFESTIONS A.Prodrome(1-2 week)1.Fever,fatigue,malaise,myalgia,drowsiness

10、,headache,vomiting2.Mental status changes3.Focal neurologic signs are absent4.CSF abnormity 12本讲稿第十二页，共四十七页CLINICAL MANIFESTIONSB.Meningeal Irritation Stage (1-2 week)1.More serious TB toxic symptoms2.Intracranial hypertension:severe headache,irritation,projectile vomiting,seizures;Bulging of anteri

11、or fontanelle,widening of cranial sutures in infant 3.Meningeal Irritation:nuchal rigidity,hypertonia Kernig sign or Brudzinski sign 4.Cranial nerve abnormalities:3,6,75.Some children have no evidence of meningeal irritation but may have signs of encephalitis:disorientation,abnormal movements and sp

12、eech impairment 13本讲稿第十三页，共四十七页CLINICAL MANIFESTIONSC.Coma Stage(1-3 week)1.Frequent convulsion,progressive altered state of consciousness:lethargy,confusion,semicoma,deep coma,decerebrate or decorticate posturing2.Depletion:extremely maransis,constipation,urinary retention 3.progressive abnormaliti

13、es of vital signs,and eventual die from cerebral hernia 14本讲稿第十四页，共四十七页Characteristics of TBM in infants and young children1.A rapid onset with convulsion,abruptly high fever2.Atypical miningeal irritation3.Intracranial hypertension manifests as bulging of anterior fontanelle and widening of cranial

14、 sutures in infant 15本讲稿第十五页，共四十七页PROGNOSISu The prognosis of tuberculous meningitis correlates most closely with the clinical stage of diagnosis and treatment.u Age:infants or younger children are generally worse than that of older childrenu Drug resistant strain u Variation of host immunityu Appro

15、priate therapeutic regimenu Completion of the antituberculor agent regimen16本讲稿第十六页，共四十七页It is imperative that antituberculosis treatment be considered for any child who develops basilar meningitis and hydrocephalus,cranial nerve palsy,or stroke with no other apparent etiology.17本讲稿第十七页，共四十七页DIAGNOS

16、IS HistoryClinical Symptoms and SignsAuxiliary Examinations18本讲稿第十八页，共四十七页DIAGNOSIS-History Elucidate the following:1.Medical and social history,including recent contact with patients with TB2.Negative history for Bacille Calmette-Guerin(BCG)vaccination3.History of immunosuppression from a known dis

17、ease or drug therapy19本讲稿第十九页，共四十七页DIAGNOSIS Symptoms and signs uA gradual onset uFever,headache,alternant of irritability and drowsiness,vomiting,constipation of unknown originuAltered mental status20本讲稿第二十页，共四十七页DIAGNOSIS Tuberculin Skin Test Purified protein derivative(PPD)1.Injected intradermall

18、y on the volar surface of the forearm2.Reaction peaks at 48 to 72 hours3.A nonreactive result does not exclude M.tuberculosis infection or disease,the tuberculin skin test is nonreactive in up to 50%of cases21本讲稿第二十一页，共四十七页DIAGNOSIS Spinal Tap Cerebrospinal Fluid1.Gross appearanceClear or slightly t

19、urbida fine clot resembling a pellicle or cobweb may form2.Cell counts,differential count50-500cells/mm3Lymphocytic predominancebut Polymorphonuclear cells may predominate early 3.GlucoseHypoglycorrhachia4.ProteinHigh protein level with 1-3g/L22本讲稿第二十二页，共四十七页DIAGNOSIS Spinal Tap Cerebrospinal Fluid5

20、.Chloridate：low 6.Acid-fast stain(+),Gram stain,India ink7.Culture for M tuberculosis(+)8.ELISA test for Specific PPD-IgM and PPD-IgG in CSF9.ELISA test for Specific TB-antigen in CSF is a sensitive and rapid method23本讲稿第二十三页，共四十七页DIAGNOSIS Spinal Tap Cerebrospinal Fluid10.Total IgG,IgA and IgM11.PC

21、R:specific PCR to detect the gene of M tuberculosis bacilli can provide a rapid and reliable diagnosis of TBM,although false-negative results potentially occur24本讲稿第二十四页，共四十七页DIAGNOSIS Chest X-ray Chest x-ray:Posteroanterior and lateral views may reveal the followinglHilar lymphadenopathylSimple pne

22、umonialInfiltratelPleural effusion/pleural scar25本讲稿第二十五页，共四十七页DIAGNOSIS CT or MRIu CT scan and MRI of the brain reveal hydrocephalus,basilar meningeal thickening,infarcts,edema,and tuberculomas,all these are helpful clues,but nonspecificu MRI and CT scan lack specificity,but help in monitoring comp

23、lications that require neurosurgery,making the differentiations,and knowing the prognosis26本讲稿第二十六页，共四十七页DIFFERENTIAL DIAGNOSISuViral Meningocephalitisu Pyogenic Meningitisu CNS Cryptococcosis27本讲稿第二十七页，共四十七页DIFFERENTIAL DIAGNOSISViral Meningocephalitis Mumps,polio,enteroviruses,Measles,Herpes virus

24、es,EBV,and Japanese encephalitis virus,etcCSF examination is the most important test in differentiating the cause of meningitis:lClear appearancelCells:50-200 cells/mm3,Mononuclear cell predominancelProtein:slightly elevated or normal lGlucose and Chloridate:normal 28本讲稿第二十八页，共四十七页DIFFERENTIAL DIAGN

25、OSISPyogenic MeningitisClinical manifestationAcute onset of intense headache,fever,nausea,vomiting,photophobia,and stiff neck Group B streptococci,Neisseria meningitidis,Streptococcus pneumoniae,Haemophilus influenzae,and Staph.aureus,etc.lPyogenic foci located other sites of the hostlTypical rash o

26、f meningococcal infectionlExamination of CSF 29本讲稿第二十九页，共四十七页DIFFERENTIAL DIAGNOSISPyogenic MeningitisTypical CSF abnormalities in meningitisinclude the following:Appearance is turbidPleocytosis of PMN(WBC counts always above 1000,even to a very high level as 10,000 cells/mm3,predominantly neutrophi

27、ls)Decreased glucose concentrationIncreased protein concentration Gram stain and culture of CSF identify the etiological organism30本讲稿第三十页，共四十七页Brain surface(Pyogenic meningitis)31本讲稿第三十一页，共四十七页TBM32本讲稿第三十二页，共四十七页DIFFERENTIAL DIAGNOSISCNS CryptococcosisuCryptococcosis is the most common fungal infec

28、tion of the central nervous system uIt is the fourth most common cause of opportunistic infections in patients with AIDSuDisease onset is usually insidious and has a longer latent perioduFever always be absent at beginning of disease uVery notable intracranial hypertension:severe headacheuVisual dis

29、turbances and papilledema are common33本讲稿第三十三页，共四十七页DIFFERENTIAL DIAGNOSISCNS CryptococcosisCSFlAppearance can be clear or turbid.lProtein levels exceed lGlucose and ChloridatelMononuclear pleocytosis,numbers vary from 50 to 500 mononuclear cells/mm3.lIt is easy to get the positive result for C neof

30、ormans of CSFlIndia ink stain is positive CSF or serum cryptococcal antigen tests are positive34本讲稿第三十四页，共四十七页Cryptococcus is a cause of meningitis,a common complication in AIDS.The organisms are usually easy to demonstrate histologically.In this slide they are the circular-to-ovoid structures with

31、thick capsules.35本讲稿第三十五页，共四十七页TREATMENTu Supportive treatment u Antituberculous drugsu Decreasing intracranial pressureu Corticosteriodsu Symptomatic treatmentu Follow-up visit 36本讲稿第三十六页，共四十七页TREATMENTSupportive treatmentuBed rest and close respiratory contacts uNutritional support are paramount u

32、Keep good hygiene for the coma children to prevent of secondary infections,help them to change position frequently to prevent decubitalu Management of electrolyte abnormalities uAntipyreticsuControl of seizures:Diazepam(Valium)37本讲稿第三十七页，共四十七页TREATMENTAntituberculous drugsuisoniazid INH,rifampin RIF

33、,pyrazinamide PZA,streptomycin SM,and sometimes ethambutol EMB.uINH and RIF are bactericidal for all M.tuberculosis population in any milieu.uSM is most effective against rapidly multiplying organisms.uPZA is most effective against organisms found in macrephages.uenter CSF readily in the presence of

34、 meningeal inflammation.38本讲稿第三十八页，共四十七页TREATMENTAntituberculous drugsu Any regimen must contain multiple drugsu In addition,the therapy must be taken regularly and continued for a sufficient period.39本讲稿第三十九页，共四十七页TREATMENTAntituberculous drugs1.intensification chemotherapy stage:3-4 months INH(15-

35、25mg/kg),RFP,PZA,SM2.consolidation chemotherapy stage:with total course 1 year at least in order to prevent relapse,permit elimination organisms persistent exist in the host INH,RFP or EMB(ethambutol)40本讲稿第四十页，共四十七页TREATMENT Decreasing intracranial pressureuDehydrant:Mannitol(MNT)uDiuretic agent:Ace

36、tazolamide Decreasing CSF secretion by the choroid plexus uVentricular tap or Open ventricular drainage uRepeat LPs and intrathecal injectionuShunting:to establish a communication between the CSF(ventricular or lumbar)and a drainage cavity.Performed only in cases of communicating hydrocephalus.Ventr

37、icular shunt to cisterna magna41本讲稿第四十一页，共四十七页TREATMENTCorticosteriodsu Children should be treated for 6-8 weeks u More effective in early stageu Decrease the immflamatory exudates,there fore lower the intracranial pressure.Relieve the meningeal irritation.Improve the CSF circulation Reduce the adhe

38、rence and prevent the hydrocephalus.u Dexamethasoneu pay attention to the side effects of corticosteriods42本讲稿第四十二页，共四十七页Criteria for RecoveryFollow-up visit u Disappearance of all clinical manifestationsu CSF examination is normalu No relapse within 2 years after completion of antituberculosis trea

39、tment43本讲稿第四十三页，共四十七页Which symptom should be excluded in the early stage of TBM?a)Drowsinessb)Low fever,night sweat,poor appetite,loss of weightc)Personality changesd)Headachee)Recurrent convulsion 44本讲稿第四十四页，共四十七页A baby who was definited as TBM when he was 1 years old and began to receive regular t

40、reatment with antituberculosis drugs.How old is he when he can be definited as full recovery?a)11/2 yb)2 yc)21/2 yd)3 ye)4 y 45本讲稿第四十五页，共四十七页Which one is the typically cellular characteristics of CSF in TBM?a)50-500 cells/mm3,with neutrophils predominanceb)50-500 cells/mm3,with mononuclear predominancec)0-50 cells/mm3,with mononuclear predominanced)1000,sometimes can above 10,000 with neutrophil predominancee)0-50cells/mm3 with neutrophils predominance46本讲稿第四十六页，共四十七页THNAK YOU!47本讲稿第四十七页，共四十七页