骨转移性乳腺癌.pptx

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1、Metastatic Breast cancer Case Report第1页General informationName:WU ChunHongAge:40y Sex:FemaleDate of admission:February 9th,2023Date of discharge:April 23th,2023第2页Chief complaintShe got hypoesthesia of lower limbs and inability to walk for more than a month第3页History of present illnessThe patient fe

2、lt pain on the back by no obvious incentives in June 2023The pain was tingling,especially in night-timeThe patient took orally traditional Chinese medicine,but had not tangible effects第4页Past,Personal&Family HistoryNo hepatitis,hypertension,or diabetesNo smoking,alcohol or drug abuseNo inherited dis

3、easesNo history of drug allergyNormal menstruation第5页Clinical findingsThe left breast presented with diffused erythema and edema,induration about size of 3.0cm*3.0cm第6页Ultrasound examinationa 3 cm left breast mass and a normal right breast 第7页Thoracic MRI examination 第8页Thoracic MRI examinationHigh-

4、density mass was shown on the seventh thoracic,and bone destruction also had been found.Enhanced MRIEnhanced MRI第9页Laboratory examination2023-02-09 1.Hepatic functions ALT 40 U/L AST 20 U/L TB Normal3.Tumor markers CA19-9 Normal2.Blood routine test Hb 82 g/L RBC 4.541012/L WBC 6.1109/L PLT 201 109/L

5、 第10页puncture biopsyShe received ultrasound guided breast core needle puncture biopsy Puncture tissue pathology:The left breast invasive ductal carcinoma第11页Primary diagnosis Breast cancer with bone metastasis第12页TreatmentOn February 11,2023 in orthopedic department,The Patient receivedthe seventh t

6、horacic tumor resection and pedicle screw fixation第13页Histological examinationSeventh thoracic tumors was identified as metastatic carcinoma,and the immunohistochemistry results showed the possibility of breast cancer bone metastasis was very large第14页IMMUNOHISTOCHEMICAL RESULTSER+PR+CerbB2-CK20-EMA

7、+,Ckpan+,CK5/6-第15页TreatmentThe patient recovered well,and then transferred into our departmentChemotherapy two times before operation:February 23,2023 March 20,2023 The chemotherapy plan was TEC第16页TreatmentAfter the chemotherapyThe lesions area of left breast showed no reduction 第17页TreatmentModif

8、ied radical Modified radical mastectomy on marchmastectomy on march31,202331,2023Bilateral oophorectomyBilateral oophorectomyOn the same dayOn the same day第18页Histological examinationThe left breast invasive ductal carcinomaThe basal resection margin of tumor was close to the surrounding normal tissueThe axillary lymph nodes metastasis(13/15)第19页ImmunohistochemicalER+PR+CerbB2-E-cad+,Ki6750%+,P53+,Ck5/6-第20页TreatmentAfter operation,the patient continued to receive chemotherapy and radiotherapy.第21页Thank you第22页