前列腺癌-课件.ppt

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1、前列腺癌前列腺癌第一組第一組 應數三 李雪萍 應數三 陳詩瑩 應數三 洪舜國 應數四 沈孟賢變異數分析變異數分析期末報告期末報告主題探討主題探討有一大學之泌尿科學團隊對於前列腺之特有抗體與各項預後臨床測量之間的關聯性感到興趣，於是針對此一主題進行研究。變數變數反應變項：反應變項：PSA level 前列腺特有之抗原於血清中 之含量變數變數解釋變項：解釋變項：X1：癌細胞之體積大小X2：前列腺之重量X3：病人之年齡X4：良性的前列腺之增殖率X5：貯精囊是否被入侵X6：莢膜之穿透層度X7：病理分化層度變異數分析變異數分析單因子單因子差異影響不之顯著之解釋變項差異影響不之顯著之解釋變項X2 X2、X

2、3 X3、X4 X4、X6 X6、X7 X7差異影響顯著之解釋變項差異影響顯著之解釋變項X1 X1、X5 X5General Linear Model:Y versus X1l lFactor Type Levels ValuesFactor Type Levels Valuesl lX1 fixed 4 1,2,3,4X1 fixed 4 1,2,3,4l lAnalysis of Variance for Y,using Adjusted SS for TestsAnalysis of Variance for Y,using Adjusted SS for Testsl lSource

3、DF Seq SS Adj SS Adj MS F Source DF Seq SS Adj SS Adj MS F P Pl l X1 3 51398 51398 17133 14.72 X1 3 51398 51398 17133 14.72 0.0000.000l lError 93 108273 108273 1164Error 93 108273 108273 1164l lTotal 96 159672Total 96 159672l lS=34.1208 S=34.1208 R-Sq=32.19%R-Sq=32.19%R-Sq(adj)=30.00%R-Sq(adj)=30.00

4、%X1不同不同level之下的比較之下的比較Level N Mean StDev -+-+-+-+Level N Mean StDev -+-+-+-+1 76 12.07 10.19 (*-)1 76 12.07 10.19 (*-)2 15 58.30 63.79 (-*-)2 15 58.30 63.79 (-*-)3 5 80.43 104.31 (-*-)3 5 80.43 104.31 (-*-)4 1 107.77 *(-*-)4 1 107.77 *(-*-)-+-+-+-+-+-+-+-+50 100 150 200 50 100 150 200C12=2 subtracte

5、d from:C12=2 subtracted from:C12 Lower Center Upper -+-+-+-C12 Lower Center Upper -+-+-+-3 -23.97 22.13 68.22 (-*-)3 -23.97 22.13 68.22 (-*-)4 -42.73 49.47 141.66 (-*-)4 -42.73 49.47 141.66 (-*-)-+-+-+-+-+-+-100 0 100 -100 0 100 C12=3 subtracted from:C12=3 subtracted from:C12 Lower Center Upper -+-+

6、-+-C12 Lower Center Upper -+-+-+-4 -70.45 27.34 125.13 (-*-)4 -70.45 27.34 125.13 (-*-)-+-+-+-+-+-+-100 0 100 -100 0 100 X5不同不同level之下的比較之下的比較Level N Mean StDev -+-+-Level N Mean StDev -+-+-1 79 14.95 15.01 (-*-)1 79 14.95 15.01 (-*-)2 10 48.65 73.45 (-*-)2 10 48.65 73.45 (-*-)3 6 59.35 55.26 (-*-)3

7、 6 59.35 55.26 (-*-)4 2 139.07 178.20 (-*-4 2 139.07 178.20 (-*-)-+-+-+-+-50 100 150 50 100 150 C16=2 subtracted from:C16=2 subtracted from:C16 Lower Center Upper -+-+-C16 Lower Center Upper -+-+-3 -36.43 10.70 57.83 (-*-)3 -36.43 10.70 57.83 (-*-)4 19.73 90.42 161.11 (-*-)4 19.73 90.42 161.11 (-*-)

8、-+-+-+-+-100 0 100 -100 0 100 C16=3 subtracted from:C16=3 subtracted from:C16 Lower Center Upper -+-+-C16 Lower Center Upper -+-+-4 5.21 79.72 154.23 (-*-)4 5.21 79.72 154.23 (-*-)-+-+-+-+-100 0 100 -100 0 100 General Linear Model:Y versus X1,X5l lFactor Type Levels ValuesFactor Type Levels Valuesl

9、lC12 fixed 4 1,2,3,4C12 fixed 4 1,2,3,4l lC16 fixed 4 1,2,3,4C16 fixed 4 1,2,3,4l lAnalysis of Variance for Y,using Adjusted SS for TestsAnalysis of Variance for Y,using Adjusted SS for Testsl l Model Modell lSource DF Reduced DF Seq SSSource DF Reduced DF Seq SSl lC12 3 3 51398.4C12 3 3 51398.4l lC

10、16 3 3 12063.8C16 3 3 12063.8l lC12*C16 9 3+34160.6C12*C16 9 3+34160.6l lError 81 87 62048.9Error 81 87 62048.9l lTotal 96 96 159671.7Total 96 96 159671.7l lS=26.7059 R-Sq=61.14%R-Sq(adj)=57.12%S=26.7059 R-Sq=61.14%R-Sq(adj)=57.12%General Linear Model:Y versus X3,X5l lFactor Type Levels ValuesFactor

11、 Type Levels Valuesl lC14 fixed 4 1,2,3,4C14 fixed 4 1,2,3,4l lC16 fixed 4 1,2,3,4C16 fixed 4 1,2,3,4l lAnalysis of Variance for Y,using Adjusted SS for TestsAnalysis of Variance for Y,using Adjusted SS for Testsl l Model Modell lSource DF Reduced DF Seq SSSource DF Reduced DF Seq SSl lC14 3 3 873.9

12、C14 3 3 873.9l lC16 3 3 46953.5C16 3 3 46953.5l lC14*C16 9 4+42831.4C14*C16 9 4+42831.4l lError 81 86 69012.9Error 81 86 69012.9l lTotal 96 96 159671.7Total 96 96 159671.7l lS=28.3280 R-Sq=56.78%R-Sq(adj)=51.75%S=28.3280 R-Sq=56.78%R-Sq(adj)=51.75%結論結論l l單因子 X1：癌細胞之體積大小 X5：貯精囊是否被入侵l l雙因子 X1：癌細胞之體積大小 X3：病人之年齡l l為何交互因子無P-value continous to be discrete 之 level數X5：貯精囊是否 被入侵THE END