消化性溃疡形成的原因英文.pptx

《消化性溃疡形成的原因英文.pptx》由会员分享，可在线阅读，更多相关《消化性溃疡形成的原因英文.pptx（18页珍藏版）》请在淘文阁 - 分享文档赚钱的网站上搜索。

1、causes aggressive factors defensive factors peptic ulcer occur第1页/共18页Aggressive Factors 3.Gastric acid and pepsin(3.Gastric acid and pepsin(胃酸与胃蛋白酶胃酸与胃蛋白酶胃酸与胃蛋白酶胃酸与胃蛋白酶)2.Adverse effects of drugs2.Adverse effects of drugs,such as NSAID,such as NSAID1.1.Helicobacter pylori infection Helicobacter pyl

2、ori infection(幽门螺杆菌感染幽门螺杆菌感染幽门螺杆菌感染幽门螺杆菌感染)4.4.othersothers第2页/共18页1.Helicobacter pylori(H.p)the evidences .the detection rate of H.p in GU is approximately70%-80%.the detection rate of H.p in DU is approximately 90%.Eradication of H.p would boost the healing of ulcer.How can H.p destroy local mucos

3、al defective/repaired mechanism?1.colonize the gastric mucosa（胃粘膜）.2.increased acid secretion第3页/共18页2.NSAID After H.p infection,NSAID is the next important cause .Research data show that NSAID use in patients with peptic ulcer and the risk of complications was significantly higher than the general

4、population.By weakening mucosal defense and repair functions eventually lead to peptic ulcer.第4页/共18页案例展示案例展示第5页/共18页 3.Acid and pepsin The eventual formation of peptic ulcer is due to acid and pepsin digestion of the mucosa itself.Because the biologic activity of pepsin is depended on the pH value.

5、When local pH value elevates to 4,pepsin cant work well.So we often say that“No acid,no ulcer.”第6页/共18页4.Other risk factors1)Smoking Smoking is an increased risk of peptic ulcer.Smoking can affect the healing of ulcer,accelerate ulcer recurrence,and increased complication of ulceration.But the mecha

6、nism isnt clear.第7页/共18页 2)Heredity Patients with peptic ulcer often have a family history of ulcer.And some studies show that blood group O（O型血人群）have a high risk to developing peptic ulcer.第8页/共18页 3)Stress High stress can stimulate vagus nerve(交感神经),which can result in high secretion of acid.第9页/

7、共18页 4)Abnormal gastroduodenal locomotion胃十二指肠功能异常DUquick gastric empty overfull acid load food storageGUmovement obstructionreflux digestive liquid 阻滞1.High acid secretion 2.Aggravating H.p infection 3.Increased bad effect of NSAID第10页/共18页Defensive Factors2.Mucosa Barrier2.Mucosa Barrier（粘膜屏障）（粘膜屏

8、障）（粘膜屏障）（粘膜屏障）1.Mucus/Bicarbonate Barrier 1.Mucus/Bicarbonate Barrier（粘液、碳酸氢盐屏障）（粘液、碳酸氢盐屏障）（粘液、碳酸氢盐屏障）（粘液、碳酸氢盐屏障）3.Mucosal Blood Flux3.Mucosal Blood Flux（胃粘膜血流屏障）（胃粘膜血流屏障）（胃粘膜血流屏障）（胃粘膜血流屏障）4.Others4.Others第11页/共18页 1.Mucus/Bicarbonate Barrier The first line of defense is mucus and bicarbonate secret

9、ion(粘液和碳酸氢盐的分泌).It stabilizes the pH between the lumen and the surface epithelial cells.Mucus gel(粘液凝胶)in patients with H.p infection was found to be structurally weak.第12页/共18页2.Mucosa BarrierThe second line of defense is the intrinsic epithelial cell defense（上皮细胞防御、粘膜屏障）The mucosal surface is a ba

10、rrier to acid back diffusion thus maintaining normal intracellular（细胞内）pH.第13页/共18页3.Mucosal Blood FluxThe third line of defense is the rich mucosal blood flow(丰富的粘膜血流屏障).The blood provides a buffer for acid neutralization（中和）as well as adequate nutrition for the metabolic（代谢）demand to maintain mucosal integrity.第14页/共18页4.Others Prostaglandin(前列腺素),can reduce the secretion of acid.Feedback regulation of gastric secretion.（胃的分泌的反馈调节）第15页/共18页conclusion when the balance between aggressive factors anddefensive factors was brokend,peptic ulcers would occur.第16页/共18页第17页/共18页感谢您的观看！第18页/共18页