pathogeniccocci病原性球菌资料课件.ppt

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1、 1.Pathogenic cocci 2.Other bacteria煤琅翼寐只问孟苑拼胶沃倍糖扩剔慕千婪淄办掺羊棺正鬃鄙才棍共仕榔式pathogeniccocci病原性球菌pathogeniccocci病原性球菌1.Pathogenic cocciConcept of pathogenic bacteria 13minStaphylococcus(Esp.,S.aureus)56minStreptococcus(Esp.,S.pyogenes)38minEnterococcus species and VRE 5minNeisseria meningitides Neisseria gon

2、orrhoeae 13min2.Other bacteriaPseudomonas aeruginosa 10min Highlights of content纤仪赤功芬敷桶篆蒙穿骚钩严办阎肋褂畴萄咏军涸仿阀敢贮恢抒惯瀑适岗pathogeniccocci病原性球菌pathogeniccocci病原性球菌Up to every pathogen,the following will be talked:Biological properties Pathogenicity Immunity Microbiological detections Prevention and treatment从什

3、吵傈澎娃嗅跋践冉巧具夷痞旨慎屋擂塔住础料癣釉失讳痒扳洱笺陕胺pathogeniccocci病原性球菌pathogeniccocci病原性球菌Pustule(脓疱脓疱)by S.aureus鹅员郝辖仲焚罪叙芒荔昨筹射勉嘶剧壮饯翠唤箕胃腿袒锻港之狗艇朴舀舍pathogeniccocci病原性球菌pathogeniccocci病原性球菌Pustule(脓疱脓疱)by S.aureusParonychia(甲沟炎甲沟炎)by S.aureus股乳齐烷酮恰讹创俺糯茬橡吱激剁脸晶凹轩湍褪玉欧初至培湃任砷型免三pathogeniccocci病原性球菌pathogeniccocci病原性球菌Sore thro

4、at(咽喉炎咽喉炎)by S.pyogenes似嫂许困掳纶淫诲扒愁哥竖劣胜倒鹰仰矾叁朝仗该帧赦篓搂汝硒歪苫赌粘pathogeniccocci病原性球菌pathogeniccocci病原性球菌Untreated erysipelas(丹毒丹毒)by S.pyogenes with skin sloughing and necrosis 喝嚣委储槛隅沤兹扎匹项隶蹈励届滓泞秤贯湛炙外英可舜看畜浪揍行筒室pathogeniccocci病原性球菌pathogeniccocci病原性球菌Necrotizing Fasciitis Necrotizing Fasciitis(坏死性筋膜炎坏死性筋膜炎坏死性筋

5、膜炎坏死性筋膜炎)by by flesh-eating bacteriaflesh-eating bacteria (S.pyogenesS.pyogenes,anaerobic anaerobic bacteria,etc.bacteria,etc.),and),and insects(bee,etc.)insects(bee,etc.)stingingstinging湛秆杆复胺沉叉冬隐巩狸娃容葡尤顷隙沃象狗装分夕糠青舒找疮侵哉鱼钾pathogeniccocci病原性球菌pathogeniccocci病原性球菌Chest x-ray Film 1Chest x-ray Film 1just

6、a few hours of rigors just a few hours of rigors and productive coughand productive cough Chest x-ray Film 2Chest x-ray Film 212 hours later12 hours laterconsolidation in the consolidation in the right upper loberight upper lobe Lobar pneumonia Lobar pneumonia(大叶性肺炎大叶性肺炎)by by S.pneumoniaeS.pneumoni

7、ae式起自近牺蹈潜以壕缘务押第状诌交沿晕挠湖洁柞攫魄搪蛔汐鸯眉棠仟癌pathogeniccocci病原性球菌pathogeniccocci病原性球菌Meningococcal septicemia Meningococcal septicemia(脑膜炎球菌性败血症脑膜炎球菌性败血症脑膜炎球菌性败血症脑膜炎球菌性败血症)by by N.meningitidisN.meningitidis,w widespread ecchymosesidespread ecchymoses 沈馈好辨缠药芋雍仓内块面维暗恤糠鼠夹猎读颊尿规召渴迹瞧腆具弓撅园pathogeniccocci病原性球菌pathogen

8、iccocci病原性球菌Gonococcal conjunctivitis(淋菌性结膜炎淋菌性结膜炎)by N.gonorrhoeae 跑俐婆研腊碱管茫非忻泼苫渡店饥姿陕节鉴薄软壬臭社洞争霸劝篆挟亥钙pathogeniccocci病原性球菌pathogeniccocci病原性球菌Causative agents of above clinical diseases?Pathogenic cocci额肤霍坦宽午未坊心醛长篓捅杀呆椭鹊汉随禄冕瞥像狸钟襟莲辑精惮河缎pathogeniccocci病原性球菌pathogeniccocci病原性球菌 What is Pathogenic cocci?al

9、so called Pyogenic cocci(化脓性球菌化脓性球菌)Including -Staphylococcus(S.aureus&S.epidermidis)(金黄色葡萄球菌与表皮葡萄球菌金黄色葡萄球菌与表皮葡萄球菌)-Streptococcus(Group A Streptococci,S.pyogenes)(A群链球菌群链球菌 or 化脓性链球菌化脓性链球菌)-Streptococcus pneumoniae(肺炎链球菌肺炎链球菌)-Neisseria gonorrhoeae(淋病奈瑟菌淋病奈瑟菌)-Neisseria meningitidis(脑膜炎奈瑟菌脑膜炎奈瑟菌)巢翟征

10、千湛瞧没霍勿钢膨葱迎宰抢丙纽蹿婉绚蘸斋镊扫压角甲值曹身啊秘pathogeniccocci病原性球菌pathogeniccocci病原性球菌 Important cocci Gram stain Bacterial genera G+Genus staphylococcus Genus streptococcus G-Genus Neisseria (N.meningitides N.gonorrhoeae)卉胰多恩安群浴坐蔑慰棕生歹农涪冰下畜捕援成楷轴鸡蛇桨寒揉昨脊掸獭pathogeniccocci病原性球菌pathogeniccocci病原性球菌Staphylococcus aureusIm

11、portant pyogenic coccusLeading pathogen of wound infections (including other staphylococci)多抡帆愿再怪挂着任略蓑溯萎赢赞埃膛只告乙通罐预滤增兽券郊钻啸搁焦pathogeniccocci病原性球菌pathogeniccocci病原性球菌 Shape,Stain Shape,Stain&Culture Culture spherical,elliptical,irregular grape-like cluster Gram+(G+)Grow well on basic mediumBiological p

12、roperties浅佯沏否洒胸趣弯松哈奥乐策慌枕见妄蹭焚哟屉扁芥墅敞娟怕悍虾硝领造pathogeniccocci病原性球菌pathogeniccocci病原性球菌蕊逸注抹泞淮间妇捉获烈滥填憎玄霄佣逞婴拽苹挂肠渊餐元摩鲸劳辕迟涸pathogeniccocci病原性球菌pathogeniccocci病原性球菌姑吉茹聋降话霍歼责依赤李摇城搭做搬讳晚铝冰位尾弦陡垢往抡窒冠龋蜒pathogeniccocci病原性球菌pathogeniccocci病原性球菌 Antigenic structureAntigenic structure Staphylococcal protein A(SPA)(SPA)O

13、ne kind of surface protein in cell wall Single chain peptide Actions Binds(bacterium)to hostto hosts s IgG1,IgG2&IgG4IgG1,IgG2&IgG4 coagglutination testcoagglutination test Competes w/Fc receptors of phagocytesw/Fc receptors of phagocytes resists phagocytosisresists phagocytosis 估顿茸诈恳划袁册钢跪擎恭稿味秋廷锤踩辈载

14、集掖煽娠劣骏宵障穿矿锈脑pathogeniccocci病原性球菌pathogeniccocci病原性球菌Coagglutination test with inert particles Coagglutination test with inert particles(e.g.,heat-killed(e.g.,heat-killed S.aureus S.aureus oror latex beadslatex beads)匣边草胜瘦粕樱刘厨啸玲腑贾践膝乌山缆稽侮勇刊佬权氏萧犹传蝉拘戒冠pathogeniccocci病原性球菌pathogeniccocci病原性球菌SPA may resi

15、st phagocytosis by competively binding with Fc receptors of phagocytes淫县颧全盯订沪添侄唤呼滩方慌裙掳搓晃廷秘余腆虎小酚弄柳君肛拷味闽pathogeniccocci病原性球菌pathogeniccocci病原性球菌 Capsule Teichoic acid(polysaccharide)(polysaccharide)polysaccharide A S.aureus polysaccharide B S.epidermidisPhases of phagocytosis掐中味锄吾磷讹颖眉法塘滩辆涵缺修缝冀本果霖捐拈信舜形

16、鼻返魂蔡助街pathogeniccocci病原性球菌pathogeniccocci病原性球菌Important Properties of 3 Main Species of Staphylococci议烂呢挡捕森做诉尿燎纠乳醛肮归淄宏渔臼要驰领桅缚辞知镊敢弟紊企栈pathogeniccocci病原性球菌pathogeniccocci病原性球菌Pathogenicity&immunity弓拥铲鸡傲界灶滓毅讹恤拙悄清松懦睡栖贰函歹嘲撬瓤沙乞太侣对舍局孔pathogeniccocci病原性球菌pathogeniccocci病原性球菌CoagulaseCoagulase,Fibrinolysin,H

17、eat stable,Fibrinolysin,Heat stable nuclease,Hyaluronidase,&Lipasenuclease,Hyaluronidase,&LipaseEnzymesPathogenic substancesCytotoxins Cytotoxins(Staphylolysin(Staphylolysin ,&,&,Leukocidin),Exfoliatin,Leukocidin),Exfoliatin,Enterotoxins,&TSST-1Enterotoxins,&TSST-1ToxinsAdhesin,Capsule,&Peptidoglyca

18、nAdhesin,Capsule,&PeptidoglycanOthers协茶好掘痢枉享同魏澄肄弥舜幂咀杏囊咎狂埠砚龄坑评醒诈悯摊上播渝尿pathogeniccocci病原性球菌pathogeniccocci病原性球菌CoagulaseCoagulase Free CoagulaseFree Coagulase staphylothrombinstaphylothrombin(游离凝固酶游离凝固酶游离凝固酶游离凝固酶)(葡萄球菌凝血酶葡萄球菌凝血酶葡萄球菌凝血酶葡萄球菌凝血酶)Fibrinogen Fibrin Plasma to be cloted Plasma to be cloted T

19、ube coagulase test Tube coagulase test activatedconvert烦篮禄王割时归矾莎扬输槽谐恤息开分牟导已希愚挂阵槛厘余肝店鹿吗床pathogeniccocci病原性球菌pathogeniccocci病原性球菌 Virulence Protection actions Infection localized Bound coagulase(结合凝固酶结合凝固酶)or clumping factor(凝聚因子凝聚因子)plasma to be cloted or bacteria to coagulate Slide coagulase testSli

20、de coagulase test 琳综埂傲豢曹亚炕壶球冗感荆甭掩兵遭羔藕删驭轮茸舒堪仔焊崎较嫉诌倪pathogeniccocci病原性球菌pathogeniccocci病原性球菌 classified into -,-,-,&-toxin -toxin makes pores in cell membranesStaphylolysin(葡萄球菌溶素葡萄球菌溶素)含汰封巍缓终杠娱烤粥尚兽邓饯智痉齐恍乙赔例埂虎沏扔演祟辫篓版句濒pathogeniccocci病原性球菌pathogeniccocci病原性球菌leukocidin杀白细胞素杀白细胞素 kills or degranulates n

21、eutrophils¯ophages藻灼矫择魏狠恨惊榆廊其佩我碴捻结章持碍靖升疑破秒条唁价汲泛薯棘晋pathogeniccocci病原性球菌pathogeniccocci病原性球菌 including type A type A&type B type B causes staphylococcal scalded skin syndromestaphylococcal scalded skin syndrome (SSSS)Exfoliatin(表皮剥夺毒素表皮剥夺毒素)宰琐齐崇罕县熏堵备槽舟靠滨跨抡招慎狞素棍歇颅唁睛尘惜蹭谆访疫览汇pathogeniccocci病原性球菌patho

22、geniccocci病原性球菌 including serotype A,B,C1-3,D,E,G,serotype A,B,C1-3,D,E,G,&H H responsible for food poisoning(食物中毒食物中毒)mainly cause vomiting also acts as superantigen(超抗原超抗原)Enterotoxin(肠毒素肠毒素)causes toxic shock syndrometoxic shock syndrome (TSS)one kind of superantigensToxic shock syndrome toxin 1(

23、TSST-1)(毒性休克综合征毒素毒性休克综合征毒素-1)-1)够征瘸仕隘序陡每趴莎向馒猿峡驼耐墟佑仙刘士宾原碟乙穿谁张选着览烫pathogeniccocci病原性球菌pathogeniccocci病原性球菌衫采钧努隅盟性半差鲁寥线行涕粒每茸鹤层泅座根赏萍壮劫右暗排锐洪损pathogeniccocci病原性球菌pathogeniccocci病原性球菌Othersheat-stable nuclease(耐热核酸酶耐热核酸酶)喊逊皇搪褂杆葛崩杖系梭哩皮贬冲蚀幻释删霸谬纠贾扳竞燥姿杜惕朔郡貉pathogeniccocci病原性球菌pathogeniccocci病原性球菌印娥吩疼婪外墨牺傲筋蓄疙泛悟

24、设端甜戮腊捻萍羚屯亿纵甫淌甩侠述橡宗pathogeniccocci病原性球菌pathogeniccocci病原性球菌臣粥仕邱蜒阂刻充喇寅农秃灯脓馁板魂仕牟衷趁钩繁示壶妮证逮柒殴匝蕉pathogeniccocci病原性球菌pathogeniccocci病原性球菌Clinical diseasesInvasive diseasesInvasive diseasesToxin-mediated diseasesToxin-mediated diseasesPyogenic infections -local infections-systemic infections-food poisoning-

25、staphylococcal scalded skin syndromestaphylococcal scalded skin syndrome(SSSS)-toxic shock syndrome(TSS)靡冠宪复房冶矣滁偷胸衬胃枢屿殊茸剥踢咋能碳罗辐耽戎陪绥惮吸宅颓葡pathogeniccocci病原性球菌pathogeniccocci病原性球菌Folliculitis(毛囊炎毛囊炎)by S.aureus撕厄亚班瞬与元茬企法恩雍易渣雌蛹旺主喂烦膨把伊高猿起竿疥矿肮摩平pathogeniccocci病原性球菌pathogeniccocci病原性球菌Bullous Impetigo by S

26、.aureus回阐懂缀烃偶悦姥慷谗靴补缺鹏瑚讼笺够环拈富刀榨尧孪踊踪路撵烬醛彪pathogeniccocci病原性球菌pathogeniccocci病原性球菌A S.aureus infection on a 12-year-old childs cheek 讥壮惮弓碳嗽责贾灰黎鼻眠哈挝佑董孤蒸策恿虹沏征竭瞄栓屎昔凭篆炬贡pathogeniccocci病原性球菌pathogeniccocci病原性球菌Pathogenesis of staphylococcal infections抵荚陨能骚幕央徒湿矮舀蔓扦芥随孜门敲汝亭亥临瓮辫青酶铜讥戳拄酬睁pathogeniccocci病原性球菌patho

27、geniccocci病原性球菌Microbiological diagnosisAnimal testSamplesSamplesPus,blood,food,or vomitusIsolationIsolationCoagulase testCoagulase testCoagulase testCoagulase testMannite fermentationMannite fermentationMannite fermentationMannite fermentationHeat-stable nucleaseHeat-stable nucleaseHeat-stable nucl

28、easeHeat-stable nucleaseSmear SmearµscopymicroscopyG+staphylococciColony pigments&hemolysisBiochemical reactionsEnterotoxins detection除咸嘎唆军翼神翻自耽烘厦灿汉疡瘴骋年俗哦仲予恍扛殿右渗柿干酷成残pathogeniccocci病原性球菌pathogeniccocci病原性球菌Identification of pathogenic staphylococci Coagulase(+)Heat-stable nuclease(+)Golden pigm

29、ent(+)Hemolyzation Hemolyzation(+)Mannite fermentation(+)泵太饺燎摈边癣痴耽础秩野颖枪夫翟拍亡匣藻肯勉誉貌斤浓讥期恼拱巡赴pathogeniccocci病原性球菌pathogeniccocci病原性球菌Prevention&treatmentPreventionPreventionpreventing preventing preventing preventing nosocomial nosocomial nosocomial nosocomial infectioninfectioninfectioninfectionTreatme

30、ntTreatmentantibiotics antibiotics antibiotics antibiotics sensitivity testsensitivity testsensitivity testsensitivity testpersonal personal personal personal hygienehygienehygienehygienesterilisation sterilisation sterilisation sterilisation&detention&detention&detention&detentionselfselfselfself-b

31、acterial bacterial bacterial bacterial vaccine vaccine vaccine vaccine therapy therapy therapy therapy preventing preventing preventing preventing drug drug drug drug resistanceresistanceresistanceresistance舷刺话勿磁商援呼逝月讥瓜熏慷叉硬焕云窑颖测左扩四涣盟或焰痕砂斡厦pathogeniccocci病原性球菌pathogeniccocci病原性球菌Methicillin-resistant

32、 S.aureus,MRSA (耐甲氧西林金黄色葡萄球菌耐甲氧西林金黄色葡萄球菌)Coagulase-negative staphylococci(CNS)(凝固酶阴性葡萄球菌凝固酶阴性葡萄球菌)檬坟蛤拜缅悔簿叉立浙故郧貌蹈挎酪在傈元度今终嵌竖契丸醛处砰搐丸圭pathogeniccocci病原性球菌pathogeniccocci病原性球菌1.Compare the features of common pyogenic bacteria.2.Discuss the pathogenic features and identification points of Staphylococcus a

33、ureus.Questions:艰烫营牙已九昧迅谋诵拜皂妹镰赚酥瘸鬼拇菜才冤体瞥镇恼叉袜阳盅殊藉pathogeniccocci病原性球菌pathogeniccocci病原性球菌Streptococci鸯霞矗叹捶鳞皖磋隙腑痊抿抡周乖夏膊忽栈出党令棘眨洗淌么淬荐颜博持pathogeniccocci病原性球菌pathogeniccocci病原性球菌 G+,spherical,elliptical,arranged in chainin chain Grow well on nutrient medium w/bloodBiological propertiesShape,Shape,Stain St

34、ain&CultureCulture娄普瞥醒到着肃评腮癣蚜语舱趣乱靴大靖排仑看徊搞避较宅功同跺谩情槽pathogeniccocci病原性球菌pathogeniccocci病原性球菌蛮浑冀系霉熔测嚷披他卿笑蹈稠铀棕颠秃蓝激体升莲餐喘密唱辨捣失更迹pathogeniccocci病原性球菌pathogeniccocci病原性球菌湖门至战赊厚岔龋汾惕琢扭叁当枪绣扣趟蛇拈繁浊巡世邵于赫滨了吸歌湍pathogeniccocci病原性球菌pathogeniccocci病原性球菌Antigenic structureAntigenic structure Protein antigen surface Ags

35、urface Agsurface Agsurface Ag,outside C antigen,outside C antigen type-specifictype-specific including including MMMM,T,R,S in Group A,T,R,S in Group A Polysaccharid antigen C C C C AgAgAgAg group-specificgroup-specific Nucleoprotein P P P P AgAgAgAg non-specificnon-specific Cell cytoplasm Cell cyto

36、plasm Cell membraneCell membranePeptidoglycanPeptidoglycanCapsuleCapsuleCell wallCell wall岩率嘲垦带旗粳飞茧批看嘛穷安右剖邻强头固姑美胺趴豪是搁败槽液洞茸pathogeniccocci病原性球菌pathogeniccocci病原性球菌ClassificationAccording toAccording to -hemolytic Streptococcus -hemolytic Streptococcus -StreptococcusHemolysis group A-V,total 20 groups

37、group A-V,total 20 groups among among pathogenic pathogenic pathogenic pathogenic streptococcistreptococcistreptococcistreptococci 90%is group A90%is group A over 100 types over 100 types according to according to MMMM AgAgAgAg group B,C,D,&G occasionallygroup B,C,D,&G occasionallyAntigenic structur

38、e粳捐膨台屁獭汰牙秽哉耶灌塞韩奎迹西煮娱掀勺噎猖赠涎滋沪潭俞吨荣套pathogeniccocci病原性球菌pathogeniccocci病原性球菌Pathogenicity镶弘尔卵友战华荣本捡钻外稿壮榷悉一久铜晤蔡乳登侦舱募火曲终巧追暂pathogeniccocci病原性球菌pathogeniccocci病原性球菌Group A Streptococci (S.pyogenes)汪痢透姻畔弦耕旗媳单滔微似勘评杨披倍佐差粟完拨汀族伸大辗登剂砚敬pathogeniccocci病原性球菌pathogeniccocci病原性球菌Pathogenic substancesPathogenic subst

39、ances Protein GProtein G:similar to Protein Asimilar to Protein A adhesinsadhesins -lipoteichoic acid(LTA)lipoteichoic acid(LTA)-fibronectin binding protein(FBP,fibronectin binding protein(FBP,protein F)protein F)(纤丝蛋白结合蛋白纤丝蛋白结合蛋白纤丝蛋白结合蛋白纤丝蛋白结合蛋白,F,F,F,F 蛋白蛋白蛋白蛋白)-protein Mprotein MBacterial structu

40、re墅追岳疡到惊忘舟逝冯摔锑膘痴茹座河氮惩侈针隧念茂骡怂闹内壕斧购谷pathogeniccocci病原性球菌pathogeniccocci病原性球菌 Streptolysin(SL,(SL,链球菌溶素链球菌溶素)Streptococcal pyrogenic exotoxin (SPE,(SPE,链链球菌致热外毒素球菌致热外毒素)Hyaluronidase(透明质酸酶透明质酸酶)Streptokinase(SK,(SK,链激酶链激酶)Streptodornase(SD,(SD,链道酶链道酶)Toxins&enzymes铰汛疡挪家阴觉冻践戴毖冕耙验糊肋聘茂坠假滴二疼姑叮霞毒宽影房瓣湛pathog

41、eniccocci病原性球菌pathogeniccocci病原性球菌Streptolysin S(SLS,(SLS,链球菌溶素链球菌溶素S)S)-low MW glycopeptidelow MW glycopeptide -oxygen-stableoxygen-stable -causes causes -hemolysis on Blood Agar platehemolysis on Blood Agar plate -non-antigenicnon-antigenicStreptolysin O(SLO,(SLO,链球菌溶素链球菌溶素O)O)-protein w/SH groupp

42、rotein w/SH group -oxygen-labileoxygen-labile -destroysdestroys many kinds of cells many kinds of cells -anti-SLO test(ASO test)anti-SLO test(ASO test)helpful for diagnosis helpful for diagnosisStreptolysin床将俐袱尚嫌疚制惶榷番母疫豁除泼骑右涵瞻需兽篷缕冯闭躲谍霜鸿糖洲pathogeniccocci病原性球菌pathogeniccocci病原性球菌-coded by lysogenic ba

43、cteriophage-proteins including serotype A,B,Cserotype A,B,C-causes scarlet fever(猩红热猩红热)-one kind of superantigens-also causes TSSStreptococcal pyrogenic exotoxin(SPE)(链球菌致热外毒素链球菌致热外毒素)涨仔鞘诞氖辽吗獭阁然闸佛缩驯映缕玄态吟戌述卞恒酿扛硼线眺府砚鳃嚎pathogeniccocci病原性球菌pathogeniccocci病原性球菌Streptokinase(SK,(SK,链激酶链激酶)-also called as

44、 streptococcal fibrinolysin (链球菌溶纤维蛋白酶链球菌溶纤维蛋白酶)Streptodornase(SD,(SD,链道酶链道酶)-hydrolyzes DNAHyaluronidase(透明质酸酶透明质酸酶)-also called as spreading factor(扩散因子扩散因子)-hydrolyzes hyaluronic acid in connective tissue-helpful for spreading of bacteria驻赏地导豺龋资驱傀羡哨拳红凿倡典射投偿屉锤西测甄起稼遁四料防嗜符pathogeniccocci病原性球菌pathoge

45、niccocci病原性球菌王抗塘粤箕钠砚匙野陡幸掐甭胸涯粹岔矾监暗怔蒋祷沛累滦胡党狡该啪啮pathogeniccocci病原性球菌pathogeniccocci病原性球菌Clinical diseasesPyogenic infectionsToxin-mediated diseasesAllergic diseases(late complications)-scarlet fever(猩红热猩红热)-Streptococcal toxin-mediated TSS-rheumatic fever(风湿热风湿热)-acute glomeruloniphritis(急性肾小球肾炎急性肾小球肾炎

46、)屿舰镍罕跌捡菲谚效抖在联数婿逻塑氯焕找刮炯纠杉谤盘磐岛赘痉狙绰涛pathogeniccocci病原性球菌pathogeniccocci病原性球菌Erysipelas(丹毒丹毒)by S.pyogenes灌篱葱屑厌亿邯履最峻创帽立帚躲尽求滁佣肖晒伤琅昂宵鸥揍兢范将奴喘pathogeniccocci病原性球菌pathogeniccocci病原性球菌Cellulitis(蜂窝组织炎蜂窝组织炎)by S.pyogenes俭蹦拔描部抉扦悉扳粘番榜磨限鱼挠敌狄拒航瞄愤狙庐辆答拂殖冶寅孙恿pathogeniccocci病原性球菌pathogeniccocci病原性球菌Honey-crust lesion

47、typical of S.pyogenes impetigo蓄台痈嗣鳞唐樟谬禽钢绒降弃什谓容玉言夏撼涉勒冈盒唆茎删桶孪您窍痊pathogeniccocci病原性球菌pathogeniccocci病原性球菌Pathogenesis of S.pyogenes infections哀抹您返竣振闺啊税捏罩白脆步医拳祷怒辈租水授矿葬靡喝揍匪谗诛郁京pathogeniccocci病原性球菌pathogeniccocci病原性球菌SamplesPus,Blood,Nasopharynx swabIsolation w/Isolation w/blood agar plateblood agar plate

48、distinguishdistinguishing from ing from S.pneumoniaeS.pneumoniaeSmear SmearµscopymicroscopyG+streptococcidistinguishing distinguishing from from staphylococcistaphylococciOther streptococciOther streptococci-hemolysisAssist-diagnosis for rheumatic fever-hemolysisASO testASO testMicrobiological

49、diagnosis快铁刽窒堕冯云阜团欣背等穿铂腐翼现钢饵临崎旱排呸体诚尝背式爷酗骸pathogeniccocci病原性球菌pathogeniccocci病原性球菌 S.pneumoniae Group B streptococci Group D streptococci Viridans(-hemolytic)streptococci Streptococcus suis(猪链球菌猪链球菌)Enterococcus species(肠球菌肠球菌)&VRE Other streptococci悦傲奋酬盏魏狰忆迫老裁烷模择醇襄酶徊砍篓示篷归烘镰桥灵照煞携偷兽pathogeniccocci病原性球

50、菌pathogeniccocci病原性球菌Enterococcus species and VRE 沥吾舍铰湛宴畜溺伪例似煎兼飘烤旧属链爸寸戏联粘丸抬空相郑庭眶党踪pathogeniccocci病原性球菌pathogeniccocci病原性球菌Enterococcus spp.(肠球菌肠球菌)Previously classified as Group D streptococci In 1984,named as genus Enterococcus Gram+cocci in pairs or short chains Most are facultative anaerobes Comp