生理学双语课件-呼吸-1.ppt

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1、respiration第五章 呼吸生理121.1.外呼吸外呼吸 肺通气肺通气（外界空气与肺泡之间的气（外界空气与肺泡之间的气体交换过程）体交换过程）肺换气肺换气(肺泡与肺毛细血管之间的肺泡与肺毛细血管之间的气体交换过程气体交换过程）呼吸的三个基本环节32.气体在血液中的运输气体在血液中的运输3.3.内（组织）呼吸内（组织）呼吸4.血液与组织、细胞之间的血液与组织、细胞之间的气体交换过程气体交换过程4肺通气和肺换气5The goals of respiration are to provide oxygen to the tissues and to remove carbon dioxide.

2、To achieve these goals,respiration can be divided into four major functional events:6(1)pulmonary ventilation,which means the inflow and outflow of air between the atmosphere and the lung alveoli;(2)(2)diffusion of oxygen and carbon dioxide between the alveoli and the blood;7(3)transport of oxygen a

3、nd carbon dioxide in the blood and body fluids to and from the cells;and(4)regulation of ventilation and other facets of respiration.This chapter is a discussion of pulmonary ventilation.8第一节第一节 肺通气肺通气9一、实现肺通气的结构特点及功一、实现肺通气的结构特点及功能能鼻、咽、喉、鼻、咽、喉、气管直到终末细支气管气管直到终末细支气管 上呼吸道上呼吸道 下呼吸道下呼吸道10111213二、肺通气原理二、肺

4、通气原理14（一）（一）肺通气肺通气的动力的动力直接动力直接动力：肺泡与大气之间的压力差：肺泡与大气之间的压力差 原动力原动力:呼吸运动呼吸运动呼吸肌收缩、舒张所造成的胸呼吸肌收缩、舒张所造成的胸廓的扩大和缩小，称为呼吸运廓的扩大和缩小，称为呼吸运 动。动。151呼吸运动呼吸运动（1）吸气运动吸气运动：膈肌膈肌收缩时中部下移，增大了胸腔收缩时中部下移，增大了胸腔的上下径，肺容积随之增大，产生的上下径，肺容积随之增大，产生吸气。吸气。平静呼吸时膈肌收缩造成的通气量 占总通气量的4/5。1617当当肋间外肌肋间外肌收缩时，增大了胸收缩时，增大了胸腔的腔的前后径和左右径前后径和左右径，肺容积，肺容积

5、随之随之 增大增大,产生吸气。产生吸气。181920（2）呼气运动呼气运动：平静呼气时，因平静呼气时，因膈肌和肋间外膈肌和肋间外肌肌 舒张，舒张，肺依靠本身的回缩力肺依靠本身的回缩力量而回位，产生呼气。量而回位，产生呼气。21 用力呼吸：用力呼吸：除上述肌肉外，有更多的吸气除上述肌肉外，有更多的吸气肌与呼气肌肌与呼气肌 参与呼吸运动。参与呼吸运动。22用力呼吸用力呼吸用力呼吸用力呼吸 吸气（主动吸气（主动吸气（主动吸气（主动）膈肌和肋间外肌收缩，膈肌和肋间外肌收缩，膈肌和肋间外肌收缩，膈肌和肋间外肌收缩，胸锁乳突肌、斜角肌也收缩胸锁乳突肌、斜角肌也收缩胸锁乳突肌、斜角肌也收缩胸锁乳突肌、斜角肌

6、也收缩呼气（主动呼气（主动呼气（主动呼气（主动）膈肌和肋间外肌舒张，膈肌和肋间外肌舒张，膈肌和肋间外肌舒张，膈肌和肋间外肌舒张，腹壁肌肉、肋间内肌收缩腹壁肌肉、肋间内肌收缩腹壁肌肉、肋间内肌收缩腹壁肌肉、肋间内肌收缩 平静呼吸平静呼吸平静呼吸平静呼吸 吸气（主动吸气（主动吸气（主动吸气（主动）膈肌和肋间外肌收缩膈肌和肋间外肌收缩膈肌和肋间外肌收缩膈肌和肋间外肌收缩 呼气（被动）呼气（被动）呼气（被动）呼气（被动）膈肌和肋间外肌舒张膈肌和肋间外肌舒张膈肌和肋间外肌舒张膈肌和肋间外肌舒张23呼吸运动呼吸运动 腹式呼吸腹式呼吸 胸式呼吸胸式呼吸膈肌舒缩引起的呼吸运动伴以腹壁的起伏，所以称为腹式呼吸（

7、abdominal breathing）。24由肋间肌舒缩使肋骨和胸骨运动所产生的呼吸运动，称为胸式呼吸。Thoracic breathing251.Mechanics Of Pulmonary Ventilation 627.4-628.3A.Muscles That Cause Lung Expansion and Contraction 629.2-630.226The lungs can be expanded and contracted in two ways:by downward and upward movement of the diaphragm to lengthen

8、or shorten the chest cavity and by elevation and depression of the ribs to increase and decrease the anteroposterior diameter of the chest cavity.27Normal quiet breathing is accomplished almost entirely by the first of the two methods,that is,by movement of the diaphragm.During inspiration,contracti

9、on of the diaphragm pulls the lower surfaces of the lungs downward.28Then,during expiration,the diaphragm simply relaxes,and the elastic recoil of the lungs,chest wall,and abdominal structures compresses the lungs.29During heavy breathing,however,extra force is achieved mainly by contraction of the

10、abdominal muscles,which pushes the abdominal contents upward against the bottom of the diaphragm.30The second method for expanding the lungs is to raise the rib cage.when the rib cage is elevated,making the anteroposterior thickness of the chest about 20 per cent greater during maximum inspiration t

11、han during expiration.31Therefore,all the muscles that elevate the chest cage are classified as muscles of inspiration,and the muscles that depress the chest cage are classified as muscles of expiration.The most important muscles that raise the rib cage are the external intercostals.32The muscles th

12、at pull the rib cage downward during expiration are(1)the abdominal recti,which have the powerful effect of pulling downward on the lower ribs at the same time that they and the other abdominal muscles compress the abdominal contents upward toward the diaphragm,and(2)the internal intercostals.33As t

13、he external intercostals they contract,they pull ribs forward,and this causes leverage on the ribs to raise them upward,thereby causing inspiration.The internal intercostals function exactly oppositely,functioning as expiratory muscles,because they angle between the ribs in the opposite direction an

14、d cause opposite leverage.342肺内压 肺内压是指肺泡内的压力。吸气初，肺内压低于大气压，空气进入肺泡。呼气初，肺内压高于大气压，肺内气体流出。吸气末和呼气末，肺内压和大气压相等。35Alveolar pressure is the pressure of the air inside the lung alveoli.When the glottis声门is open and no air is flowing into or out of the lungs,the pressures in all parts of the respiratory tree,al

15、l the way to the alveoli,are equal to atmospheric pressure,which is considered to be the zero reference pressure in the airways that is,0 centimeters water pressure.36 To cause inward flow of air into the alveoli during inspiration,the pressure in the alveoli must fall to a value slightly below atmo

16、spheric pressure(below 0).37During normal inspiration,alveolar pressure decreases to about 1 centimeter of water.This slight negative pressure is enough to pull 0.5 liter of air into the lungs in the 2 seconds required for normal quiet inspiration.38During expiration,opposite changes occur:The alveo

17、lar pressure rises to about+1 centimeter of water,and this forces the 0.5 liter of inspired air out of the lungs during the 2 to 3 seconds of expiration.393.3.胸内压胸内压胸膜腔内的压力称为胸膜腔内的压力称为胸内压胸内压。4041胸膜腔内压比大气压低，为负压。平静呼气末胸膜腔内压约为53mmHg，吸气末约为105mmHg。42胸内压=大气压肺回缩力43胸内压=肺内压肺弹性回缩力 =大气压 肺弹性回缩力若以1个大气压为0，则胸膜腔内压=肺弹

18、性回缩力4445Pleural pressure is the pressure of the fluid in the narrow space between the lung pleura and the chest wall pleura.46Pleural pressure is normally a slightly negative pressure.The normal pleural pressure at the beginning of inspiration is about 5 centimeters of water,which is the amount of s

19、uction that is required to hold the lungs open to their resting level.47Then,during normal inspiration,the expansion of the chest cage pulls outward on the lungs with still greater force and creates a still more negative pressure to an average of about 7.5 centimeters of water.48（二）肺通气的阻力（二）肺通气的阻力弹性

20、阻力弹性阻力（70%70%）非弹性阻力非弹性阻力（30%30%）491 1、弹性阻力和顺应性、弹性阻力和顺应性、弹性阻力和顺应性、弹性阻力和顺应性（1 1）弹性阻力弹性阻力弹性阻力弹性阻力弹性组织在外力作用下变形时，弹性组织在外力作用下变形时，弹性组织在外力作用下变形时，弹性组织在外力作用下变形时，有对抗变形和弹性回位的倾向，有对抗变形和弹性回位的倾向，有对抗变形和弹性回位的倾向，有对抗变形和弹性回位的倾向，为弹性阻力。为弹性阻力。为弹性阻力。为弹性阻力。50（2 2）顺应性顺应性顺应性顺应性(compliance)(compliance)顺应性是指在外力作用下弹性顺应性是指在外力作用下弹性顺

21、应性是指在外力作用下弹性顺应性是指在外力作用下弹性组织的可扩张性。组织的可扩张性。组织的可扩张性。组织的可扩张性。容易扩张者，顺应性大，弹性容易扩张者，顺应性大，弹性容易扩张者，顺应性大，弹性容易扩张者，顺应性大，弹性阻力小；阻力小；阻力小；阻力小；反之则相反。反之则相反。反之则相反。反之则相反。51可见顺应性（可见顺应性（C）与弹性阻）与弹性阻力（力（R）成反变关系：）成反变关系：C=1/R52顺应性用单位压力变化（顺应性用单位压力变化（P）所引起的容积变化（所引起的容积变化（V）来表）来表示示，单位是，单位是L/cmH2O，即，即 C=V/PL/cmH2O。53Compliance in

22、the respiratory system 631.2633.1describes the distensibility of the lungs and chest wall.is inversely related to elastance,which depends on the amount of elastic tissue.is the change in volume for a given change in pressure.54 肺的肺的肺的肺的弹性阻力弹性阻力弹性阻力弹性阻力 肺表面张力肺表面张力肺表面张力肺表面张力（2/32/3）肺组织弹性（肺组织弹性（肺组织弹性（肺

23、组织弹性（1/31/3）(3)肺的肺的弹性阻力弹性阻力的来源的来源55肺组织的弹性肺组织的弹性主要来肺组织的弹主要来肺组织的弹性纤维和胶原纤维。性纤维和胶原纤维。56Resistence to pulmonary ventilation633.2634.4Resistant forces of the lungs.These can be divided into two parts:(1)the elastic forces of the lung tissue itself57The elastic forces of the lung tissue are determined main

24、ly by the elastin and collagen fibers interwoven among the lung parenchyma.(2)the elastic forces caused by surface tension of the fluid that lines the inside walls of the alveoli and other lung air spaces.58Nature of Lung Elastic RecoilThe elastic recoil of the lung consists of two kinds of forcesti

25、ssue forces and surface tension forces.The elasticity of lung tissue is due principally to elastin弹性 蛋 白fibers in alveolar walls and surrounding small airways.59 肺泡表面张力肺泡表面张力肺泡表面张力肺泡表面张力肺泡内壁有一薄层液体，它与肺泡肺泡内壁有一薄层液体，它与肺泡肺泡内壁有一薄层液体，它与肺泡肺泡内壁有一薄层液体，它与肺泡内气体形成了液内气体形成了液内气体形成了液内气体形成了液-气交界面，这里存气交界面，这里存气交界面，这里存气

26、交界面，这里存在减小液在减小液在减小液在减小液-气界面的力，使肺泡趋于气界面的力，使肺泡趋于气界面的力，使肺泡趋于气界面的力，使肺泡趋于缩小，称为缩小，称为缩小，称为缩小，称为肺泡表面张力。肺泡表面张力。肺泡表面张力。肺泡表面张力。60 肺泡表面活性物质肺泡表面活性物质是由是由肺泡肺泡 型细胞型细胞分泌的一种复分泌的一种复杂的杂的脂蛋白脂蛋白，主要成分为二棕榈，主要成分为二棕榈酰卵磷脂。其主要作用是酰卵磷脂。其主要作用是降低表降低表面张力面张力。61LaplaceLaplace定律：定律：P=2T/r p P=2T/r p 肺泡肺泡内压内压T T 表面张力表面张力 r r 肺泡半径肺泡半径由于

27、小肺泡表面活性物质的密由于小肺泡表面活性物质的密度大，大肺泡表面活性物质分度大，大肺泡表面活性物质分子的子的 稀疏，则大小肺泡内压力稀疏，则大小肺泡内压力相等，大小肺泡的稳定性。相等，大小肺泡的稳定性。62 肺泡表面活性物质的作用肺泡表面活性物质的作用降低表面张力降低表面张力 维持大小肺泡的容积相维持大小肺泡的容积相对稳定对稳定调节肺泡的回缩力，有调节肺泡的回缩力，有利呼吸利呼吸使肺泡表面相对干燥，使肺泡表面相对干燥，避免肺水肿避免肺水肿63The surface tension accounts for about two thirds of the total elastic forces

28、 in the normal lungs.The surface tension elastic forces of the lungs also increase tremendously when the substance called surfactant is not present in the alveolar fluid.64Surfactant is a surface active agent,which means that it greatly reduces the surface tension of the water.It is secreted by spec

29、ial surfactantsecreting epithelial cells that constitute about 10 per cent of the surface area of the alveoli.These cells are are called type II alveolar epithelial cells.65Surfactant is a complex mixture of several phospholipids,proteins,and ions.Surfactant consists primarily of the phospholipid,(D

30、PPC)which is responsible for reducing the surface tension.66Abnormalities of Lung Elastic RecoilLung elastic recoil is increased by reduced surfactant activity resulting from decreased synthesis or inactivation.The best-known clinical disorder associated with decreased surfactant synthesis is the re

31、spiratory distress syndrome of the newborn.67Surfactant production may also beimpaired following the interruption of pulmonary perfusion,as in pulmonary thromboembolism血栓栓塞.Hydrostatic pulmonary edema and adult respiratory distress syndrome are associated with surfactant inactivation due to alveolar

32、 flooding.68The consequences of decreased surfactant activity include decreased lung compliance due to increasedsurface tension and alveolar collapse(atelectasis肺 萎 陷),decreased lung volumes(TLC,total lung capacity,RV residual volume,and FRC functional residual capacity),and increased elastic work o

33、f breathing.69The decreased lung compliance of interstitial or infiltrative浸润性的lung diseases results from two mechanisms decreased distensibility and lung shrinkage70Pathologically these diseases are characterized by alveolar filling with inflammatory exudate渗 出 物and/or replacement of alveoli by fib

34、rosis,and this loss of alveolar units or lungshrinkage decreases compliance(see above).71In addition,these disorders may alter theconnective tissue elements of the lung.resulting in increased lung elastic recoil.As a result,TLC,RV,and functional residual capacity are decreased,and the elastic work o

35、f breathing is increased in these disorders.722 2、非弹性阻力、非弹性阻力包括包括:惯性阻力惯性阻力 粘滞阻力粘滞阻力 气道阻力气道阻力73惯性阻力是气流在发动、变速、换向时因气流和组织的惯性所产生的。平静呼吸时，惯性阻力小，可忽略不计。74粘滞阻力粘滞阻力来自呼吸时组织相来自呼吸时组织相对位移所发生的磨擦。对位移所发生的磨擦。75气道阻力气道阻力来自来自气体分子间和气体气体分子间和气体分子与气道之间的磨擦，是非弹分子与气道之间的磨擦，是非弹性阻力的性阻力的主要成分主要成分，约占，约占80%-90%。76R R与与1/r1/r4 4成正比成正比影

36、响影响r r的因素：的因素：1 1、气道管壁平滑肌的神经调节、气道管壁平滑肌的神经调节2 2、化学因素的影响、化学因素的影响77（三）呼吸功（三）呼吸功78三、基本肺容积和肺容量三、基本肺容积和肺容量（一）（一）基本肺容积基本肺容积（pulmonary pulmonary volume)volume)1 1潮气量潮气量 每次呼吸时吸入每次呼吸时吸入或或呼出呼出的气量为潮气量（的气量为潮气量（tidal volumetidal volume）。）。平静呼吸时，潮气量为平静呼吸时，潮气量为500ml 500ml。运。运动时增大。动时增大。792补吸气量平静吸气末，再尽力吸气所能吸入的气量为补吸气量

37、（inspiratory reserve volume），正常为15002000ml。803补呼气量 平静呼气末，再尽力呼气所能呼出的气量为补呼气量（expiratory reserve volume），正常为9001200ml。814余气量 最大呼气末尚存留于肺中不能再呼出的气量为余气量（residual volume）。正常为10001500ml。82（二）（二）肺容量肺容量（pulmonary capacitiespulmonary capacities）是基本肺容积中两项或两项以上的是基本肺容积中两项或两项以上的联合联合气量。气量。1 1深吸气量深吸气量 从平静呼气末作最大吸气时所能吸

38、入的从平静呼气末作最大吸气时所能吸入的气量为深吸气量，它是潮气量和补吸气气量为深吸气量，它是潮气量和补吸气量之和。量之和。832功能余气量 平静呼气末尚存留于肺内的气量为功能余气量。是余气量和补呼气量之和。843肺活量最大吸气后，从肺内所能呼出的最大气量称作肺活（vital capacity），是潮气量、补吸气量和补呼气量之和。正常成年男性平均约为3500ml，女性为2500ml。85864.时间肺活量先深吸气，然后以最快的速度呼出气体，同时分别测量第1、2、3s末呼出的气量，计算其所占肺活量的百分数（正常人各为83%、96%和99%肺活量。)8788时间肺活量不仅反映肺活量容量的大小，而且反

39、映了呼吸所遇阻力的变化，所以是评价肺通气功能的较好指标。89Pulmonary Volumes And Capacities628.3629.1A.Pulmonary Volumes1.The tidal volume is the volume of air inspired or expired with each normal breath;it amounts to about 500 milliliters.902.The inspiratory reserve volume is the maximum extra volume of air that can be inspire

40、d over and above the normal tidal volume;it is usually equal to about 3000 milliliters.913.The expiratory reserve volume is the maximum extra volume of air that can be expired by forceful expiration after the end of a normal tidal expiration;this normally amounts to about 1100 milliliters.924.The re

41、sidual volume is the volume of air remaining in the lungs after the most forceful expiration.This volume averages about 1200 milliliters.93Pulmonary CapacitiesIn describing events in the pulmonary cycle,it is sometimes desirable to consider two or more of the volumes together.Such combinations are c

42、alled pulmonary capacities.94The vital capacity equals the inspiratory reserve volume plus the tidal volume plus the expiratory reserve volume.This is the maximum amount of air a person can expel from the lungs after first filling the lungs to their maximum extent and then expiring to the maximum ex

43、tent(about 4600 milliliters).95 The total lung capacity is the maximum volume to which the lungs can be expanded with the greatest possible effort(about 5800 milliliters);it is equal to the vital capacity plus the residual volume.96All pulmonary volumes and capacities are about 20 to 25 per cent les

44、s in women than in men,and they are greater in large and athletic people than in small and asthenic无力的people.97To perform a forced vital capacity(FVC)maneuver,the subject inhales to total lung capacity,exhales as forcefully and rapidly as possible to residual volume,and then returns toTLC by a rapid

45、 forceful inhalation.98During forced inspiration,flow increases rapidly above residual volume becausethe inspiratory muscles function most advantageously at low lung volumes.As inspiration progresses,flow remainshigh because airway resistance falls as lung volume increases.Near TLC flow decreases as

46、 the inspiratory muscles shorten,and inspiratory force decreases.99=12=121818 500500=69L/min=69L/min四、四、肺通气量肺通气量（一）每分通气量和每分最大通气量（一）每分通气量和每分最大通气量每分通气量每分通气量=呼吸频率呼吸频率 潮气量潮气量100The minute respiratory volume is the total amount of new air moved into the respiratory passages each minute;this is equal to t

47、he tidal volume times the respiratory rate.The normal tidal volume is about 500 milliliters,and the normal respiratory rate is about 12 breaths per minute.Therefore,the minute respiratory volume averages about 6 L/min.101每分最大通气量尽力作深快呼吸时，每分钟所能吸入或呼出的最大气量为最大通气量。102（二）（二）无效腔（无效腔（dead space)dead space)和肺

48、泡通气量和肺泡通气量生理无效腔生理无效腔 解剖无效腔解剖无效腔（150ml150ml）肺泡无效腔肺泡无效腔103Dead space 636.56a.Anatomic dead space is the volume of the conducting airways.is normally approximately 150 ml104Some of the air a person breathes never reaches the gas exchange areas but instead goes to fill respiratory passages where gas exc

49、hange does not occur,such as in the nose,pharynx,and trachea.105This air is called dead space air because it is not useful for the gas exchange process;the space in the respiratory passages where no gas exchange takes place is called the dead space.106Normal Dead Space Volume.The normal dead space a

50、ir in a young adult man is about 150 milliliters.This increases slightly with age.107The volume of all the space of the respiratory system besides the alveoli and their other closely related gas exchange areas;this space is called the anatomic dead space.108 On occasion,some of the alveoli themselve