人乳头状瘤病毒感染诱发头颈鳞癌的研究进展35295.pdf

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12、ne Ther,2001,8(8):638-645.20 U rano N,Fuji wara Y,DokiY,etal.Overexpression of hypox ia-in-ducible factor-1 alpha in gastricadenocarcinoma J.Gastric Canc-er,2006,9(1):44-49.21 G riffithsEA,Pritchard SA,Va lentineHR,eta l.Hypoxia-induciblefactor-1alpha expression in the gastric carcinogenesis sequenc

13、e andits prognostic role in gastric and gastro-oesophageal adenocarcino-mas J.Br J Cancer,2007,15,96(1):95-103.:2008-09-25:2008-11-20杨 洁,李晓江,隋 军*(,650118):R739.91 :A :1006-2084(2009)01-0073-03 :人乳头状瘤病毒(HPV)16/18在头颈肿瘤的恶性转化过程中起很着重要的作用,HPV侵犯皮肤及黏膜鳞状上皮,早期蛋白 6 7与 p53作用,致使 p53基因表达下调,从而促使头颈恶性肿瘤的发生 发展本文综述了 H

14、PV的分子生物学特性和致癌机制及与头颈肿瘤的关系:人乳头状瘤病毒;头颈鳞癌ResearchAdvancementonHPVInfectionInducingHead-neckSquamousCarcinoma Y ANGJie,L I Xiao-jiang,SUIJun.(D e part mento f O tolaryngologyandH eadSurgery,the Third Affiliated H ospita l ofKunmingM e dica l Colleg e,Kunming650118,China)Abstract:Human papillomavirus(HPV)

15、16/18 play an i mportant role in the process of head-necktu mormalignant translation,HPV can infect skin and mucous squamous epithelium,early protein 6 7 caneffect P53,then the expression ofP53 decline,so accelerate the happening and development of head-neckmalignant tumor.The article summarizes the

16、 relation between the molecularbiology characteristic,carcino-genesismechanism ofHPV and head-neck tumorKeywords:Human papillorr mavirus(HPV);Head-neck squamous carcinoma (human papillomavirus,HPV),HPV,Sanchez-Lanier 1,HPV3:;,90%,#73#20091151 Medical Recapitulate,Jan 2009,V o.l 15,No.11 HPV1.1 HPV H

17、PV20,DNA,72HPV,HPV 16/18,3:2E()L(),E,E L6 8,6,4500 kb,E l E2 E4 E5 E6E7;2,L1L2E2 E6 E7E6p53,P53,G1S,DNA;E7Rb,E2FRB,E2F,Gl/s,2p53Rb 3HPVE6 E7,E6E7 4E6E7,5,6HPV16 18E6/E7 71.2 HPV HPV,DNADNA,HPV E2E6 E7 8,E6E7E6E7E6 E7p53RbE6E6(E6-AP),p53p53,p21Cdks,p53DNADNA,p53G1,E7HPV,(Rb),H avre 9,10,p53HPV16 E6,F

18、oster 11,HPV16 E7M0,M02 HPV,120HPV 12,13HPV6 HPV11HPV,HPV,HPV,HPVHPV16 HPV18HPV,HPVHPV16 18 33,(HPV),HPV,HPV,60%100%,HPVHPV,.HPV,HPV,Gillison 1425362(24.5%)HPV,90.0%HPV16HPV2.1 HPV Gillison 14HPV,pRb,Rb2.2 HPV Torrente 15HPV32%,HPV16DcSou-za 16100200,HPV,#74#20091151 M edicalR ecapitulate,Jan 2009,V

19、o.l 15,No.112,HPV1632Torrente 15,32%HPV DNA,HPV 16,DNADu 17HPV 16 E6 E7,Bc-l2Bak,p53 caspase-3caspase-8,HPV 16 E6 E7Bc-l2Bak,HPV 16HPV 16 E6,E7,HPV 16E6 E7(1 4)(1 3)HPV 16,HPV16E6 E7HPV 16E6 E7,2.3 HPV HPV,W oods 18,0%100%,HPVE6p53,HPV1618E6HPVE6,p53,3 HPV,HPV,19,HPV 20,21HPV16/18,DNA,HPV1618,HPV 1

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