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1、 Journal of Clinical Oncology List of Issues Volume 37,Issue 4_suppl Meeting Abstract|2019 Gastrointestinal Cancers SymposiumCANCERS OF THE PANCREAS,SMALL BOWEL,AND HEPATOBILIARY TRACTEfficacy and safety of dabrafenib(D)andtrametinib(T)in patients(pts)with BRAFV600Emutated biliary tract cancer(BTC):

2、Acohort of the ROAR basket trial.Rights&PermissionsArticlehas analtmetricscore of 13OPTIONS&TOOLSExport CitationTrack CitationAdd To FavoritesADVERTISEMENTADADVERTISEMENTLog InSubmitE-AlertsCartOpenAthens/Shibboleth MENU Article ToolsZev A.Wainberg,Ulrik Niels Lassen,Elena Elez,Antoine Italiano,Gius

3、eppeCurigliano,Filippo G.De Braud,.Show MoreAbstract Disclosures187Background:BTCs are rare,aggressivemalignancies with poor prognoses.Treatmentoptions and outcomes after first-line therapy arenot well defined.Median progression-free survival(PFS)in second-line BTC is 5 mo.Combined BRAF+MEK inhibiti

4、on is efficacious in BRAF V600mutated anaplastic thyroid cancer,melanoma,and lung cancer,but less so in BRAF V600E-mutated colorectal cancer.Activating BRAF V600Emutations have been reported in 0%to 20%ofBTCs;thus,D(BRAF inhibitor)+T(MEK inhibitor)was evaluated as a treatment for pts with BRAFV600Em

5、utated BTC in the ROAR basket trial.COMPANION ARTICLESNo companion articlesARTICLE CITATIONDOI:10.1200/JCO.2019.37.4_suppl.187Journal of Clinical Oncology 37,no.4_suppl(February 01,2019)187-187.Published online January 29,2019.WE RECOMMENDADVERTISEMENTEmployer:Merritt HawkinsApply for this job Emplo

6、yer:Potomac Oncology&HematologyApply for this job Hematology-Oncology OpportunityJust Outside of ChicagoRockford,Illinois N/AA reputable integrated health system seekinga board-certified or board-eligiblehematologist-oncologist to join its team.Oncology&Hematology AssociatePositionRockville,Maryland

7、 Competitive SalaryThis position offers a competitive base salary,a comprehensive benefits package,exceptional productivity incentives,and apartnership track.Hematology/Oncology-at the Beach inLow Tax Delaware!Delaware(US);Family-oriented resort area inbeautiful south coastal DelawareAbstractBRAF/ME

8、K Targeting May YieldBenefit in Treating Biliary TractCancerBy Caroline Helwick,The ASCO Post,2019BRAF/MEK Targeting May YieldBenefit in Treating Biliary TractCancerBy Caroline Helwick et al.,Hepatobiliary Cancer,2019Encorafenib Plus Cetuximab as aNew Standard of Care for PreviouslyTreated BRAF V600

9、EMutantMetastatic Colorectal Cancer:Updated Survival Results andSubgroup Analyses from theBEACON StudyJosep Tabernero et al.,J Clin Oncol,2021The Right Treatment for the RightTargets in BRAF-Mutant MetastaticMethods:In this phase II,open-label trial,pts withBRAF V600E mutations in 9 rare tumor types

10、,including BTC,received D(150 mg BID)+T(2 mgQD)until unacceptable toxicity,diseaseprogression,or death.Eligible pts had advancedor metastatic cancer and had been treated with 1 prior systemic therapy.The primary endpointwas investigator-assessed overall response rate(ORR).Secondary endpoints include

11、d duration ofresponse(DOR),PFS,overall survival(OS),biomarker correlates,and safety.Results:Thirty-three pts with BTC had enrolled at data cutoff(January 3,2018).BRAF V600E mutations werecentrally confirmed in 30 of 33 pts with BTC(91%).Median age was 58 y,and 78%had received 2prior lines of systemi

12、c therapy.32 of 33 pts withBTC were evaluable.Investigator-assessed ORRwas 41%(13/32;95%CI,24%-59%),with 6 of 13responses ongoing at data cutoff,7 of 13 pts(54%)had a DOR 6 mo.Median PFS was 7.2 mo(95%CI,4.6-10.1 mo),and median OS was 11.3 mo(95%CI,7.3-17.6 mo).Grade 3/4 adverse events in 3pts were

13、increased-glutamyltransferase(n=3ADVERTISEMENTCRCAlberto Puccini et al.,ASCO DailyNews,2019Heinz-Josef Lenz,MD,on BRAFV600EMutated Biliary Tract Cancer:Results From the ROAR Basket TrialHepatobiliary Cancer1 MILO/ENGOT-OV11:Phase-3 studyof binimetinib versus physicianschoice chemotherapy(PCC)inrecur

14、rent or persistent low-gradeserous carcinomas of the ovary,fallopian tube,or primaryperitoneumR Grisham et al.,InternationalJournal of Gynecologic Cancer,2019Association of BRAF V600E/KMutation Status and Prior BRAF/MEKInhibition With PembrolizumabOutcomes in Advanced Melanoma:Pooled Analysis of 3 C

15、linical TrialsIgor Puzanov et al.,JAMA Oncology,2020Vemurafenib for BRAF V600MutantErdheim-Chester Disease andLangerhans Cell Histiocytosis:Analysis of Data From the Histology-Independent,Phase 2,Open-labelVE-BASKET StudyEli L.Diamond et al.,JAMA Oncology,2018281 Real-world-data on platinumoutcomes

16、after parp inhibitorsprogression in high grade serousovarian cancer patientsAndrea Plaja Salarich et al.,International Journal of Gynecologic9%)and decreased white blood cell count(n=3pts 9%).Biomarker analyses demonstrate aheterogeneous genetic landscape,and suggest ahigher baseline expression of M

17、APK pathwaygenes in the pts who did not respond to D+T.Conclusions:D+T demonstrated promisingefficacy in pts with BTC,with a favorable safetyprofile.These pts should be considered for BRAFmutation analysis,and D+T should be consideredfor pts with BRAF V600E-mutated BTC.Clinical trialinformation:NCT0

18、2034110.2019 by American Society of Clinical OncologyCancer,2020Camrelizumab plus gemcitabine andoxaliplatin(GEMOX)in patients withadvanced biliary tract cancer:asingle-arm,open-label,phase II trialXiaofeng Chen et al.,Jitc,2020Powered byQUICK LINKSContentNewest Articles Archive Meeting AbstractsJou

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