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1、 Journal of Clinical Oncology List of Issues Volume 39,Issue 3_suppl Meeting Abstract|2021 Gastrointestinal Cancers SymposiumHEPATOBILIARY CANCERLenvatinib plus pembrolizumab for patientswith previously treated biliary tract cancersin the multicohort phase II LEAP-005 study.Rights&PermissionsOPTIONS

2、&TOOLSExport CitationTrack CitationAdd To FavoritesCOMPANION ARTICLESADVERTISEMENTADADVERTISEMENTLog InSubmitE-AlertsCartOpenAthens/Shibboleth MENU Article ToolsLuis Villanueva,Zarnie Lwin,Hyun Cheol Chung,Carlos Gomez-Roca,Federico Longo,Eduardo Yanez,.Show MoreAbstract Disclosures321Background:Sec

3、ond-line treatment options forpatients with biliary tract cancers(BTC)arelimited.Lenvatinib,an anti-angiogenic multikinaseinhibitor,in combination with the programmeddeath-1 immune checkpoint inhibitorpembrolizumab,has demonstrated promisingantitumor activity with a manageable safetyprofile in patie

4、nts with select advanced solidtumors.LEAP-005(NCT03797326)is evaluating theefficacy and safety of lenvatinib pluspembrolizumab in patients with previously treatedadvanced solid tumors;here we present resultsfrom the BTC cohort of LEAP-005.Methods:In thisNo companion articlesARTICLE CITATIONDOI:10.12

5、00/JCO.2021.39.3_suppl.321Journal of Clinical Oncology 39,no.3_suppl(January 20,2021)321-321.Published online January 22,2021.WE RECOMMENDADVERTISEMENTEmployer:Merritt HawkinsApply for this job Employer:Potomac Oncology&HematologyApply for this job Hematology-Oncology OpportunityJust Outside of Chic

6、agoRockford,Illinois N/AA reputable integrated health system seekinga board-certified or board-eligiblehematologist-oncologist to join its team.Oncology&Hematology AssociatePositionRockville,Maryland Competitive SalaryThis position offers a competitive base salary,a comprehensive benefits package,ex

7、ceptional productivity incentives,and apartnership track.Hematology/Oncology-at the Beach inLow Tax Delaware!Delaware(US);Family-oriented resort area inbeautiful south coastal DelawareAbstractPhase Ib Study of Lenvatinib PlusPembrolizumab in Patients WithUnresectable HepatocellularCarcinomaRichard S

8、.Finn et al.,J Clin Oncol,20202018 ASCO:KEYNOTE-427 TrialEvaluates Pembrolizumab inAdvanced Clear Cell Renal CellCarcinomaBy The ASCO Post,The ASCO Post,20182018 ASCO:KEYNOTE-427 TrialEvaluates Immunotherapy inAdvanced Clear Cell Renal CellCarcinomaBy The ASCO Post et al.,KidneyCancer,2018Lenvatinib

9、 Plus Pembrolizumab inPatients With Advanced EndometrialCancerVicky Makker et al.,J Clin Oncol,2020nonrandomized,open-label,phase II study,eligible patients were aged 18 years withhistologically or cytologically documentedadvanced(metastatic and/or unresectable)BTCwith disease progression after 1 pr

10、ior line oftherapy,measurable disease per RECIST v1.1,ECOG PS of 01,and tissue sample evaluable forPD-L1 expression.Patients received lenvatinib 20mg once daily plus pembrolizumab 200 mg Q3Wfor up to 35 cycles(approximately 2 years)or untilconfirmed disease progression,unacceptabletoxicity,or withdr

11、awal of consent.Treatment withlenvatinib could continue beyond 2 years inpatients experiencing clinical benefit.Primaryendpoints were ORR(per RECIST v1.1 by blindedindependent central review)and safety.Secondaryendpoints were the disease control rate(DCR;comprising CR,PR,and SD),duration of response

12、(DOR),PFS,and OS.Tumor imaging wasperformed Q9W from treatment initiation for 54weeks,then Q12W to week 102,and Q24Wthereafter.Results:31 patients were enrolled inthe BTC cohort(ECOG PS 1,55%;84%ex-US).As ofADVERTISEMENTOpen-Label,Single-Arm,Phase IIStudy of PembrolizumabMonotherapy as First-Line Th

13、erapy inPatients With Advanced NonClearCell Renal Cell CarcinomaDavid F.McDermott et al.,J ClinOncol,2021Pembrolizumab Plus Chemo With orWithout Bevacizumab Approved forCervical CancerBy staff,US Pharmacist,2021KEYNOTE-013 4-year follow-up ofpembrolizumab in classical Hodgkinlymphoma after brentuxim

14、abvedotin failureArmand,Blood Advances,2020FDA Approves Another Indication forPembrolizumabBy staff,US Pharmacist,2020Current and future drugcombination strategies based onprogrammed death-1/programmeddeath-ligand 1 inhibitors in non-small cell lung cancerYing Li Cheng et al.,Chinese MedicalJournal,

15、2021Comparison and analysis of theefficacy of drug therapy for livercancerPhilippe Merle et al.,HepatomaResearch-OAE Publishing,2020Powered byApril 10,2020,median time from first dose to datacutoff(DCO)was 9.5 months(range,3.111.9),with 16 patients on treatment at DCO.There were3(10%)PRs and 18(58%)

16、SDs.ORR was 10%(95%CI,226),and DCR was 68%(95%CI,4983).Median DOR was 5.3 months(range,2.1+to 6.2).Median PFS was 6.1 months(95%CI,2.16.4).Median OS was 8.6 months(95%CI,5.6 to NR).Treatment-related AEs occurred in 30 patients(97%),including 15(48%)who had grade 34 AEs;there were no treatment-relate

17、d deaths.2(6%)discontinued treatment due to treatment-relatedAEs(myocarditis,pyrexia;n=1 each).The mostfrequent treatment-related AEs were hypertension(42%),dysphonia(39%),diarrhea(32%),fatigue(32%),and nausea(32%).14 patients(45%)hadimmune-mediated AEs and 1 patient(3%)had aninfusion-related reacti

18、on.Conclusions:Lenvatinibplus pembrolizumab demonstrated encouragingefficacy and manageable toxicity in patients withadvanced BTC who had received 1 line of priortherapy.Based on these data,enrollment in theBTC cohort has been expanded to 100 patients.Clinical trial information:NCT03797326.2021 Amer

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