2023年遗传学试卷(最新版)最全面精品资料complex disorders.pdf

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1、 1.When is the female genital duct development completed?(14.0分)A.At 7 weeks B.At9-10 weeks of gestation C.At10-11 weeks of gestation D.At18-20 weeks of gestation E.Between8 and 20 weeks of gestation 2.To say that two alleles are in linkage disequilibrium implies that:(12.0分)A.The alleles are so clo

2、se that recombination never occurs between them.B.The alleles function together in the same pathway.C.One allele arose from the other by mutation.D.The two alleles are together in the same haplotype more often that predicted by chance.3.Association Studies:(12.0分)A.Can give false positive results du

3、e to population stratification B.Include the transmission disequilibrium test(TDT)C.Positive association studies should be replicated D.Are used to map genes in multifactorial disorders E.Require close lymatched control and patient groups 4.Linkage analysis is more difficult in multifactorial condit

4、ions than in single-gene disorders because:(12.0 分)A.Variants in more than 1 gene are likely to contribute to the disorder B.The number of affected persons within in a family is likely to be fewer than for a single-gene disorder C.The mode of inheritance is usually uncertain D.Some multifactorial di

5、sorders are likely to have more than 1 etiology E.Many multifactorial conditions have a late age of onset F.All of above.5.A multifactorial trait occurs more often in females than males.A couple have an affected son.Which of the following is true regarding their risk of recurrence?(12.0分)A.Recurrenc

6、e is higher than if they had an affected daughter,and is most likely for a future daughter.B.Recurrence is higher than if they had an affected daughter,and is most likely for a future son.C.Recurrence is higher than if they had an affected daughter,and is most likely for a future daughter.D.Recurren

7、ce is lower than if they had an affected daughter,and is most likely for a future daughter.6.Which of the following statements is incorrect regarding the recurrence risk of multifactorial inherited disorders.(12.0分)A.The risk gets higher when the degree of relationship increases B.The risk gets high

8、er when the number of patients in the family increase C.The risk for their children gets higher when the patients are seriously affected D.The risk gets higher when one or both parents are affected.7.Multiple studies of a given disorder among siblings have estimated the heritability of the disorder

9、as equal to 0.85.What does this finding reveal about the cause of this disorder?(12.0 分)A.The majority of the variance in the phenotype of this disease is caused by genetic influences B.This disorder is likely caused by a single gene,with no environmental influences C.Environmental factors exert a g

10、reater influence over disease likelihhood than genetic factors 8.A four-year old child with abnormal speech has a bifiduvula.What is the correct diagnosis?(14.0 分)悬雍垂裂，不涉及软腭和硬腭，能讲话但有影响，A.A submucous cleft palate 腭粘膜下裂 B.A cleft of the primary palate 主要腭的分裂 C.A complete cleft of the secondary palate 一个完整的唇裂继发腭 D.A complete cleft of the soft palate 一个完整的软腭裂 E.A normal palate with a functional speech impediment 一个功能性障碍的正常腭