[精选]HISTOCOMPATIBILITYCOMPLEX(主要组织相容性复合体).pptx
( 4.5 )《[精选]HISTOCOMPATIBILITYCOMPLEX(主要组织相容性复合体).pptx》由会员分享，可在线阅读，更多相关《[精选]HISTOCOMPATIBILITYCOMPLEX(主要组织相容性复合体).pptx（51页珍藏版）》请在淘文阁 - 分享文档赚钱的网站上搜索。
1、CHAPTER 11THE MAJOR HISTO PATIBILITY PLEXI.Introduction Major histo patibility antigen system Major histo patibility plex:A large genetic locus that includes the highly polymorphic genes encoding the peptide-binding molecules recognized by T lymphocytes.The MHC locus also includes genes encoding cyt
2、okines,molecules involved in antigen processing,and plement proteins.H-2 plex:murine MHCs HLA:human MHC which is known as the human leucocytes antigen system.Three classes of MHC genes closely linked on chromosome Classgene Classgene ClassgeneII.The organization of murine and human MHC1.Mouse H-2 pl
3、ex:Classgene:K,DL class molecules chain Classgene:I class molecules chain Classgene:S plement,TNFS K ID/LChr.17 centromereH-22.Human HLA plex:DP DN DO DQ DR B C E A GHLA complexcentromere Chr.6class loci Proteins encodingHLA class Classical B,C,A HLA class moleculesNon-classical E,F,GHLA class Class
4、ical DP,DQ,DR HLA class ImoleculesNon-classical DN,DOHLA class plement,TNF,HSPV.Genetics of MHC Polygenic Polymorphic Haplotype inherited CodominantA.HLA-molecules III.The structure and function of MHC molecules1.Structure Two polypeptide chain:H-chain and 2-microglobulin not coded by the MHC Heavy
5、chain has 3 domains:1,2,3.Heavy chain 1and2 domains form the binding groove the polymorphic region 3 domain bind to CD82.Cellular distibution Class molecules are expressed on all nucleated cells all cells except for RBC Exists in the form of Membrane bound molecules Soluble molecules2.Functioni.Anti
6、gen processing and presenting endogeneous pathway peptides generated in the cytosol eg.Virus antigen be e associated with MHC class molecules which move to the surface and can be recognized by CD8+T cell cytotoxic T lymphocytes.ii.Involve in transplant rejectioniii.T cell development in thymusB.HLA-
7、molecules1.Structure Heterodimers of andglycoprotein chains.Each chain has 2domains 1,2 and 1,2 1 and 1 form the binding groove.the polymorphic region CD4 bind to 2 domain2.Cellular distribution class molecules are expressed on B cells M Dendritic cells Vascular endothelial cells3.Functions i.Antige
8、n processing and presenting exogeneous pathway:both pathogens in cellular vesicles and those e from outside the cell are presented on MHC class molecules of APCs and are transported to the cell surface where they can be recognized by CD4+T cellii.Involve in transplant rejectioniii.Regulation of immu
- 配套讲稿：
如PPT文件的首页显示word图标，表示该PPT已包含配套word讲稿。双击word图标可打开word文档。
- 特殊限制：
部分文档作品中含有的国旗、国徽等图片，仅作为作品整体效果示例展示，禁止商用。设计者仅对作品中独创性部分享有著作权。
- 关 键 词：
- 精选 HISTOCOMPATIBILITYCOMPLEX 主要 组织 相容性 复合体
淘文阁 - 分享文档赚钱的网站所有资源均是用户自行上传分享，仅供网友学习交流，未经上传用户书面授权，请勿作他用。
限制150内